| Full name: syntaxin binding protein 6 | Alias Symbol: amisyn|HSPC156 | ||
| Type: protein-coding gene | Cytoband: 14q11.2 | ||
| Entrez ID: 29091 | HGNC ID: HGNC:19666 | Ensembl Gene: ENSG00000168952 | OMIM ID: 607958 |
| Drug and gene relationship at DGIdb | |||
Expression of STXBP6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | STXBP6 | 29091 | 220994_s_at | -1.0515 | 0.3794 | |
| GSE20347 | STXBP6 | 29091 | 220994_s_at | 0.0613 | 0.7695 | |
| GSE23400 | STXBP6 | 29091 | 220995_at | -0.1230 | 0.0010 | |
| GSE26886 | STXBP6 | 29091 | 220994_s_at | 0.3299 | 0.4310 | |
| GSE29001 | STXBP6 | 29091 | 220995_at | -0.0658 | 0.7306 | |
| GSE38129 | STXBP6 | 29091 | 220994_s_at | -0.6072 | 0.0451 | |
| GSE45670 | STXBP6 | 29091 | 220994_s_at | -1.2840 | 0.0001 | |
| GSE53622 | STXBP6 | 29091 | 23045 | -1.4011 | 0.0000 | |
| GSE53624 | STXBP6 | 29091 | 47244 | -1.2024 | 0.0000 | |
| GSE63941 | STXBP6 | 29091 | 220994_s_at | 0.0208 | 0.9886 | |
| GSE77861 | STXBP6 | 29091 | 220994_s_at | -0.0228 | 0.9507 | |
| GSE97050 | STXBP6 | 29091 | A_23_P205713 | -0.6638 | 0.2253 | |
| SRP064894 | STXBP6 | 29091 | RNAseq | -0.8302 | 0.0704 | |
| SRP133303 | STXBP6 | 29091 | RNAseq | -0.1492 | 0.7214 | |
| SRP159526 | STXBP6 | 29091 | RNAseq | -0.0465 | 0.9378 | |
| SRP219564 | STXBP6 | 29091 | RNAseq | -1.2032 | 0.3264 | |
| TCGA | STXBP6 | 29091 | RNAseq | -1.3231 | 0.0023 |
Upregulated datasets: 0; Downregulated datasets: 4.
Survival by STXBP6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of STXBP6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | STXBP6 | 29091 | 8 | 2 | 20 | |
| GSE20123 | STXBP6 | 29091 | 8 | 2 | 20 | |
| GSE43470 | STXBP6 | 29091 | 9 | 2 | 32 | |
| GSE46452 | STXBP6 | 29091 | 16 | 2 | 41 | |
| GSE47630 | STXBP6 | 29091 | 11 | 10 | 19 | |
| GSE54993 | STXBP6 | 29091 | 3 | 11 | 56 | |
| GSE54994 | STXBP6 | 29091 | 18 | 5 | 30 | |
| GSE60625 | STXBP6 | 29091 | 0 | 2 | 9 | |
| GSE74703 | STXBP6 | 29091 | 8 | 2 | 26 | |
| GSE74704 | STXBP6 | 29091 | 3 | 2 | 15 | |
| TCGA | STXBP6 | 29091 | 27 | 12 | 57 |
Total number of gains: 111; Total number of losses: 52; Total Number of normals: 325.
Somatic mutations of STXBP6:
Generating mutation plots.
Highly correlated genes for STXBP6:
Showing top 20/773 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| STXBP6 | L1CAM | 0.850994 | 3 | 0 | 3 |
| STXBP6 | CACNA1H | 0.843625 | 4 | 0 | 4 |
| STXBP6 | TUBB4A | 0.797998 | 3 | 0 | 3 |
| STXBP6 | NCR1 | 0.78592 | 3 | 0 | 3 |
| STXBP6 | CA14 | 0.780022 | 3 | 0 | 3 |
| STXBP6 | RPGRIP1 | 0.77828 | 3 | 0 | 3 |
| STXBP6 | P2RX2 | 0.758993 | 4 | 0 | 3 |
| STXBP6 | RNASE4 | 0.74957 | 3 | 0 | 3 |
| STXBP6 | PAX3 | 0.749019 | 3 | 0 | 3 |
| STXBP6 | CHD5 | 0.745878 | 4 | 0 | 4 |
| STXBP6 | BTN1A1 | 0.745399 | 3 | 0 | 3 |
| STXBP6 | FAM163A | 0.742967 | 4 | 0 | 4 |
| STXBP6 | PEG3 | 0.742122 | 3 | 0 | 3 |
| STXBP6 | RASD2 | 0.740082 | 3 | 0 | 3 |
| STXBP6 | SV2C | 0.738677 | 3 | 0 | 3 |
| STXBP6 | GNRHR | 0.738602 | 3 | 0 | 3 |
| STXBP6 | IL5RA | 0.7372 | 3 | 0 | 3 |
| STXBP6 | MUC2 | 0.733262 | 3 | 0 | 3 |
| STXBP6 | DISC1 | 0.729663 | 3 | 0 | 3 |
| STXBP6 | PNLIPRP1 | 0.726929 | 3 | 0 | 3 |
For details and further investigation, click here
