| Full name: cytochrome P450 family 17 subfamily A member 1 | Alias Symbol: P450C17|CPT7|S17AH | ||
| Type: protein-coding gene | Cytoband: 10q24.32 | ||
| Entrez ID: 1586 | HGNC ID: HGNC:2593 | Ensembl Gene: ENSG00000148795 | OMIM ID: 609300 |
| Drug and gene relationship at DGIdb | |||
CYP17A1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04913 | Ovarian steroidogenesis | |
| hsa04917 | Prolactin signaling pathway |
Expression of CYP17A1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CYP17A1 | 1586 | 205502_at | -0.0490 | 0.9062 | |
| GSE20347 | CYP17A1 | 1586 | 205502_at | -0.1127 | 0.1146 | |
| GSE23400 | CYP17A1 | 1586 | 205502_at | -0.1740 | 0.0005 | |
| GSE26886 | CYP17A1 | 1586 | 205502_at | 0.3525 | 0.0359 | |
| GSE29001 | CYP17A1 | 1586 | 205502_at | -0.1649 | 0.2719 | |
| GSE38129 | CYP17A1 | 1586 | 205502_at | -0.0775 | 0.3496 | |
| GSE45670 | CYP17A1 | 1586 | 205502_at | 0.1283 | 0.2008 | |
| GSE53622 | CYP17A1 | 1586 | 36087 | -0.0088 | 0.9055 | |
| GSE53624 | CYP17A1 | 1586 | 36087 | 0.0595 | 0.5721 | |
| GSE63941 | CYP17A1 | 1586 | 205502_at | 0.0222 | 0.9180 | |
| GSE77861 | CYP17A1 | 1586 | 205502_at | -0.0018 | 0.9919 | |
| GSE97050 | CYP17A1 | 1586 | A_33_P3376478 | 0.0908 | 0.6871 | |
| TCGA | CYP17A1 | 1586 | RNAseq | -3.2042 | 0.0001 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by CYP17A1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CYP17A1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CYP17A1 | 1586 | 2 | 9 | 19 | |
| GSE20123 | CYP17A1 | 1586 | 2 | 8 | 20 | |
| GSE43470 | CYP17A1 | 1586 | 0 | 8 | 35 | |
| GSE46452 | CYP17A1 | 1586 | 0 | 11 | 48 | |
| GSE47630 | CYP17A1 | 1586 | 2 | 14 | 24 | |
| GSE54993 | CYP17A1 | 1586 | 8 | 0 | 62 | |
| GSE54994 | CYP17A1 | 1586 | 1 | 11 | 41 | |
| GSE60625 | CYP17A1 | 1586 | 0 | 0 | 11 | |
| GSE74703 | CYP17A1 | 1586 | 0 | 5 | 31 | |
| GSE74704 | CYP17A1 | 1586 | 1 | 4 | 15 | |
| TCGA | CYP17A1 | 1586 | 5 | 29 | 62 |
Total number of gains: 21; Total number of losses: 99; Total Number of normals: 368.
Somatic mutations of CYP17A1:
Generating mutation plots.
Highly correlated genes for CYP17A1:
Showing top 20/1065 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CYP17A1 | MAGEA8 | 0.765238 | 3 | 0 | 3 |
| CYP17A1 | CHRNB4 | 0.761126 | 3 | 0 | 3 |
| CYP17A1 | KATNAL2 | 0.745419 | 3 | 0 | 3 |
| CYP17A1 | MAMLD1 | 0.737645 | 3 | 0 | 3 |
| CYP17A1 | LACRT | 0.7325 | 4 | 0 | 4 |
| CYP17A1 | CLCNKA | 0.730831 | 3 | 0 | 3 |
| CYP17A1 | SLC29A4 | 0.724666 | 3 | 0 | 3 |
| CYP17A1 | C1QTNF1 | 0.720942 | 3 | 0 | 3 |
| CYP17A1 | DEFB108B | 0.716937 | 3 | 0 | 3 |
| CYP17A1 | FGF22 | 0.716136 | 5 | 0 | 5 |
| CYP17A1 | ANO7 | 0.713142 | 4 | 0 | 4 |
| CYP17A1 | CELA3B | 0.712906 | 4 | 0 | 3 |
| CYP17A1 | TMEM229A | 0.711383 | 3 | 0 | 3 |
| CYP17A1 | C20orf85 | 0.709345 | 4 | 0 | 3 |
| CYP17A1 | CD72 | 0.709147 | 3 | 0 | 3 |
| CYP17A1 | ADRA2B | 0.707542 | 5 | 0 | 5 |
| CYP17A1 | HSD3B1 | 0.707046 | 4 | 0 | 4 |
| CYP17A1 | TXNDC2 | 0.704016 | 5 | 0 | 4 |
| CYP17A1 | BSX | 0.703686 | 3 | 0 | 3 |
| CYP17A1 | SLCO1A2 | 0.702408 | 3 | 0 | 3 |
For details and further investigation, click here
