| Full name: betaine--homocysteine S-methyltransferase 2 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 5q14.1 | ||
| Entrez ID: 23743 | HGNC ID: HGNC:1048 | Ensembl Gene: ENSG00000132840 | OMIM ID: 605932 |
| Drug and gene relationship at DGIdb | |||
Expression of BHMT2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | BHMT2 | 23743 | 219902_at | -1.5018 | 0.1787 | |
| GSE20347 | BHMT2 | 23743 | 219902_at | -0.2999 | 0.1356 | |
| GSE23400 | BHMT2 | 23743 | 219902_at | -0.3100 | 0.0004 | |
| GSE26886 | BHMT2 | 23743 | 219902_at | -0.0538 | 0.7282 | |
| GSE29001 | BHMT2 | 23743 | 219902_at | 0.0350 | 0.8565 | |
| GSE38129 | BHMT2 | 23743 | 219902_at | -0.8266 | 0.0208 | |
| GSE45670 | BHMT2 | 23743 | 219902_at | -1.8995 | 0.0000 | |
| GSE53622 | BHMT2 | 23743 | 48618 | -1.5289 | 0.0000 | |
| GSE53624 | BHMT2 | 23743 | 48618 | -1.7534 | 0.0000 | |
| GSE63941 | BHMT2 | 23743 | 219902_at | -3.4221 | 0.0000 | |
| GSE77861 | BHMT2 | 23743 | 219902_at | 0.0041 | 0.9691 | |
| GSE97050 | BHMT2 | 23743 | A_24_P231829 | -0.9353 | 0.1440 | |
| SRP064894 | BHMT2 | 23743 | RNAseq | -0.5702 | 0.1211 | |
| SRP133303 | BHMT2 | 23743 | RNAseq | -1.1560 | 0.0000 | |
| SRP159526 | BHMT2 | 23743 | RNAseq | -0.9832 | 0.0558 | |
| SRP193095 | BHMT2 | 23743 | RNAseq | 0.3414 | 0.0375 | |
| SRP219564 | BHMT2 | 23743 | RNAseq | -0.7708 | 0.4778 | |
| TCGA | BHMT2 | 23743 | RNAseq | -1.4010 | 0.0004 |
Upregulated datasets: 0; Downregulated datasets: 6.
Survival by BHMT2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of BHMT2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | BHMT2 | 23743 | 1 | 13 | 16 | |
| GSE20123 | BHMT2 | 23743 | 1 | 13 | 16 | |
| GSE43470 | BHMT2 | 23743 | 1 | 13 | 29 | |
| GSE46452 | BHMT2 | 23743 | 0 | 28 | 31 | |
| GSE47630 | BHMT2 | 23743 | 1 | 19 | 20 | |
| GSE54993 | BHMT2 | 23743 | 8 | 1 | 61 | |
| GSE54994 | BHMT2 | 23743 | 1 | 19 | 33 | |
| GSE60625 | BHMT2 | 23743 | 0 | 0 | 11 | |
| GSE74703 | BHMT2 | 23743 | 1 | 9 | 26 | |
| GSE74704 | BHMT2 | 23743 | 1 | 6 | 13 | |
| TCGA | BHMT2 | 23743 | 5 | 49 | 42 |
Total number of gains: 20; Total number of losses: 170; Total Number of normals: 298.
Somatic mutations of BHMT2:
Generating mutation plots.
Highly correlated genes for BHMT2:
Showing top 20/1362 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| BHMT2 | ARHGAP6 | 0.864611 | 10 | 0 | 10 |
| BHMT2 | PARD3B | 0.856303 | 5 | 0 | 5 |
| BHMT2 | ASB5 | 0.855531 | 6 | 0 | 6 |
| BHMT2 | DIXDC1 | 0.850576 | 9 | 0 | 9 |
| BHMT2 | C3orf70 | 0.849584 | 5 | 0 | 5 |
| BHMT2 | SYNPO2 | 0.848566 | 6 | 0 | 6 |
| BHMT2 | RBPMS2 | 0.844441 | 6 | 0 | 6 |
| BHMT2 | FILIP1 | 0.842188 | 5 | 0 | 5 |
| BHMT2 | MRVI1 | 0.840646 | 7 | 0 | 6 |
| BHMT2 | MYOCD | 0.83782 | 7 | 0 | 7 |
| BHMT2 | RAB9B | 0.837089 | 6 | 0 | 6 |
| BHMT2 | KCNT2 | 0.831856 | 6 | 0 | 6 |
| BHMT2 | SMOC2 | 0.831375 | 5 | 0 | 5 |
| BHMT2 | PGM5-AS1 | 0.829713 | 3 | 0 | 3 |
| BHMT2 | NEXN | 0.824613 | 7 | 0 | 6 |
| BHMT2 | FENDRR | 0.823281 | 6 | 0 | 5 |
| BHMT2 | ANK2 | 0.820337 | 10 | 0 | 10 |
| BHMT2 | TCEAL2 | 0.819288 | 8 | 0 | 8 |
| BHMT2 | SMAD9 | 0.814876 | 6 | 0 | 6 |
| BHMT2 | PRKAR2B | 0.8126 | 9 | 0 | 9 |
For details and further investigation, click here
