| Full name: neuroligin 1 | Alias Symbol: KIAA1070 | ||
| Type: protein-coding gene | Cytoband: 3q26.31 | ||
| Entrez ID: 22871 | HGNC ID: HGNC:14291 | Ensembl Gene: ENSG00000169760 | OMIM ID: 600568 |
| Drug and gene relationship at DGIdb | |||
Expression of NLGN1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NLGN1 | 22871 | 205893_at | -0.8463 | 0.1889 | |
| GSE20347 | NLGN1 | 22871 | 205893_at | 0.1103 | 0.4818 | |
| GSE23400 | NLGN1 | 22871 | 205893_at | -0.1069 | 0.0001 | |
| GSE26886 | NLGN1 | 22871 | 231361_at | 0.4451 | 0.2076 | |
| GSE29001 | NLGN1 | 22871 | 205893_at | 0.0195 | 0.8902 | |
| GSE38129 | NLGN1 | 22871 | 205893_at | -0.2474 | 0.4261 | |
| GSE45670 | NLGN1 | 22871 | 231361_at | -1.0611 | 0.0000 | |
| GSE53622 | NLGN1 | 22871 | 37541 | -1.3064 | 0.0000 | |
| GSE53624 | NLGN1 | 22871 | 37541 | -1.2071 | 0.0000 | |
| GSE63941 | NLGN1 | 22871 | 205893_at | -3.4989 | 0.0001 | |
| GSE77861 | NLGN1 | 22871 | 231361_at | 0.0086 | 0.9164 | |
| GSE97050 | NLGN1 | 22871 | A_33_P3214690 | -0.5702 | 0.2858 | |
| SRP064894 | NLGN1 | 22871 | RNAseq | -1.4138 | 0.0008 | |
| SRP133303 | NLGN1 | 22871 | RNAseq | -1.0382 | 0.0182 | |
| SRP159526 | NLGN1 | 22871 | RNAseq | -0.2952 | 0.6303 | |
| SRP219564 | NLGN1 | 22871 | RNAseq | -0.6497 | 0.4805 | |
| TCGA | NLGN1 | 22871 | RNAseq | -0.9755 | 0.0144 |
Upregulated datasets: 0; Downregulated datasets: 6.
Survival by NLGN1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NLGN1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NLGN1 | 22871 | 23 | 0 | 7 | |
| GSE20123 | NLGN1 | 22871 | 23 | 0 | 7 | |
| GSE43470 | NLGN1 | 22871 | 23 | 0 | 20 | |
| GSE46452 | NLGN1 | 22871 | 19 | 1 | 39 | |
| GSE47630 | NLGN1 | 22871 | 27 | 2 | 11 | |
| GSE54993 | NLGN1 | 22871 | 1 | 15 | 54 | |
| GSE54994 | NLGN1 | 22871 | 41 | 0 | 12 | |
| GSE60625 | NLGN1 | 22871 | 0 | 6 | 5 | |
| GSE74703 | NLGN1 | 22871 | 19 | 0 | 17 | |
| GSE74704 | NLGN1 | 22871 | 15 | 0 | 5 | |
| TCGA | NLGN1 | 22871 | 78 | 0 | 18 |
Total number of gains: 269; Total number of losses: 24; Total Number of normals: 195.
Somatic mutations of NLGN1:
Generating mutation plots.
Highly correlated genes for NLGN1:
Showing top 20/984 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NLGN1 | C1QTNF7 | 0.798272 | 5 | 0 | 5 |
| NLGN1 | SMAD9 | 0.77212 | 7 | 0 | 7 |
| NLGN1 | CASQ2 | 0.771652 | 7 | 0 | 7 |
| NLGN1 | AFF3 | 0.770675 | 4 | 0 | 4 |
| NLGN1 | PARD3B | 0.764697 | 5 | 0 | 5 |
| NLGN1 | FIBIN | 0.761711 | 4 | 0 | 4 |
| NLGN1 | RGS7BP | 0.759535 | 5 | 0 | 5 |
| NLGN1 | FXYD1 | 0.75902 | 6 | 0 | 5 |
| NLGN1 | UBXN10 | 0.759009 | 4 | 0 | 4 |
| NLGN1 | MYOC | 0.755445 | 7 | 0 | 7 |
| NLGN1 | ITGA7 | 0.752967 | 7 | 0 | 7 |
| NLGN1 | SGCA | 0.750286 | 7 | 0 | 7 |
| NLGN1 | SLIT3 | 0.748749 | 6 | 0 | 6 |
| NLGN1 | MYOM1 | 0.746541 | 7 | 0 | 7 |
| NLGN1 | CYP21A2 | 0.745421 | 3 | 0 | 3 |
| NLGN1 | FENDRR | 0.744702 | 5 | 0 | 5 |
| NLGN1 | ILDR2 | 0.743572 | 4 | 0 | 4 |
| NLGN1 | PPP1R12B | 0.743287 | 7 | 0 | 7 |
| NLGN1 | ARHGAP6 | 0.742776 | 9 | 0 | 8 |
| NLGN1 | NEGR1 | 0.742398 | 7 | 0 | 6 |
For details and further investigation, click here
