| Full name: sortilin related VPS10 domain containing receptor 1 | Alias Symbol: sorCS1 | ||
| Type: protein-coding gene | Cytoband: 10q25.1 | ||
| Entrez ID: 114815 | HGNC ID: HGNC:16697 | Ensembl Gene: ENSG00000108018 | OMIM ID: 606283 |
| Drug and gene relationship at DGIdb | |||
Expression of SORCS1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SORCS1 | 114815 | 228194_s_at | -0.9883 | 0.2059 | |
| GSE26886 | SORCS1 | 114815 | 228194_s_at | 0.0574 | 0.6215 | |
| GSE45670 | SORCS1 | 114815 | 1556891_at | -0.0254 | 0.8017 | |
| GSE53622 | SORCS1 | 114815 | 87113 | -2.4860 | 0.0000 | |
| GSE53624 | SORCS1 | 114815 | 87113 | -2.3467 | 0.0000 | |
| GSE63941 | SORCS1 | 114815 | 1556891_at | 0.0749 | 0.5963 | |
| GSE77861 | SORCS1 | 114815 | 1556891_at | -0.0635 | 0.6146 | |
| GSE97050 | SORCS1 | 114815 | A_33_P3414192 | -0.7009 | 0.2027 | |
| SRP064894 | SORCS1 | 114815 | RNAseq | -0.3859 | 0.4714 | |
| SRP133303 | SORCS1 | 114815 | RNAseq | -2.6903 | 0.0000 | |
| SRP159526 | SORCS1 | 114815 | RNAseq | -1.9480 | 0.0294 | |
| TCGA | SORCS1 | 114815 | RNAseq | -2.1250 | 0.0001 |
Upregulated datasets: 0; Downregulated datasets: 5.
Survival by SORCS1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SORCS1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SORCS1 | 114815 | 1 | 9 | 20 | |
| GSE20123 | SORCS1 | 114815 | 1 | 8 | 21 | |
| GSE43470 | SORCS1 | 114815 | 0 | 7 | 36 | |
| GSE46452 | SORCS1 | 114815 | 0 | 11 | 48 | |
| GSE47630 | SORCS1 | 114815 | 2 | 14 | 24 | |
| GSE54993 | SORCS1 | 114815 | 8 | 0 | 62 | |
| GSE54994 | SORCS1 | 114815 | 1 | 10 | 42 | |
| GSE60625 | SORCS1 | 114815 | 0 | 0 | 11 | |
| GSE74703 | SORCS1 | 114815 | 0 | 5 | 31 | |
| GSE74704 | SORCS1 | 114815 | 1 | 4 | 15 | |
| TCGA | SORCS1 | 114815 | 5 | 30 | 61 |
Total number of gains: 19; Total number of losses: 98; Total Number of normals: 371.
Somatic mutations of SORCS1:
Generating mutation plots.
Highly correlated genes for SORCS1:
Showing top 20/911 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SORCS1 | XKR4 | 0.918393 | 4 | 0 | 4 |
| SORCS1 | CASQ2 | 0.901502 | 4 | 0 | 4 |
| SORCS1 | ANO5 | 0.896959 | 4 | 0 | 4 |
| SORCS1 | HPSE2 | 0.895664 | 4 | 0 | 4 |
| SORCS1 | ARHGAP6 | 0.892831 | 4 | 0 | 4 |
| SORCS1 | CYP21A2 | 0.885012 | 3 | 0 | 3 |
| SORCS1 | KCNB1 | 0.884725 | 4 | 0 | 4 |
| SORCS1 | ASPA | 0.883861 | 4 | 0 | 4 |
| SORCS1 | C1QTNF7 | 0.883771 | 4 | 0 | 4 |
| SORCS1 | CCDC69 | 0.881189 | 4 | 0 | 4 |
| SORCS1 | MYOC | 0.88005 | 4 | 0 | 4 |
| SORCS1 | NCAM1 | 0.879797 | 4 | 0 | 4 |
| SORCS1 | PDE5A | 0.878554 | 4 | 0 | 4 |
| SORCS1 | CLEC3B | 0.876006 | 3 | 0 | 3 |
| SORCS1 | PGR | 0.874189 | 4 | 0 | 4 |
| SORCS1 | CACNB2 | 0.873892 | 4 | 0 | 4 |
| SORCS1 | ASB5 | 0.868742 | 4 | 0 | 4 |
| SORCS1 | SCN7A | 0.865978 | 4 | 0 | 4 |
| SORCS1 | MAMDC2 | 0.863761 | 4 | 0 | 4 |
| SORCS1 | MRVI1 | 0.861754 | 4 | 0 | 4 |
For details and further investigation, click here
