| Full name: SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1 | Alias Symbol: testican-1 | ||
| Type: protein-coding gene | Cytoband: 5q31.2 | ||
| Entrez ID: 6695 | HGNC ID: HGNC:11251 | Ensembl Gene: ENSG00000152377 | OMIM ID: 602264 |
| Drug and gene relationship at DGIdb | |||
Expression of SPOCK1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SPOCK1 | 6695 | 202363_at | 0.0608 | 0.9650 | |
| GSE20347 | SPOCK1 | 6695 | 202363_at | 1.2961 | 0.0003 | |
| GSE23400 | SPOCK1 | 6695 | 202363_at | 0.4554 | 0.0000 | |
| GSE26886 | SPOCK1 | 6695 | 202363_at | 2.3352 | 0.0001 | |
| GSE29001 | SPOCK1 | 6695 | 202363_at | 1.0443 | 0.0126 | |
| GSE38129 | SPOCK1 | 6695 | 202363_at | 1.2137 | 0.0014 | |
| GSE45670 | SPOCK1 | 6695 | 202363_at | -0.6187 | 0.3721 | |
| GSE53622 | SPOCK1 | 6695 | 57039 | 1.4766 | 0.0000 | |
| GSE53624 | SPOCK1 | 6695 | 57039 | 2.2960 | 0.0000 | |
| GSE63941 | SPOCK1 | 6695 | 202363_at | -4.8536 | 0.0017 | |
| GSE77861 | SPOCK1 | 6695 | 202363_at | 0.8947 | 0.0120 | |
| GSE97050 | SPOCK1 | 6695 | A_24_P354689 | 0.2429 | 0.4168 | |
| SRP007169 | SPOCK1 | 6695 | RNAseq | 5.1124 | 0.0000 | |
| SRP008496 | SPOCK1 | 6695 | RNAseq | 5.0774 | 0.0000 | |
| SRP064894 | SPOCK1 | 6695 | RNAseq | 1.1594 | 0.0019 | |
| SRP133303 | SPOCK1 | 6695 | RNAseq | 2.4987 | 0.0000 | |
| SRP219564 | SPOCK1 | 6695 | RNAseq | 2.2437 | 0.0003 | |
| TCGA | SPOCK1 | 6695 | RNAseq | 0.3789 | 0.0471 |
Upregulated datasets: 11; Downregulated datasets: 1.
Survival by SPOCK1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SPOCK1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SPOCK1 | 6695 | 3 | 10 | 17 | |
| GSE20123 | SPOCK1 | 6695 | 4 | 10 | 16 | |
| GSE43470 | SPOCK1 | 6695 | 4 | 6 | 33 | |
| GSE46452 | SPOCK1 | 6695 | 0 | 27 | 32 | |
| GSE47630 | SPOCK1 | 6695 | 0 | 21 | 19 | |
| GSE54993 | SPOCK1 | 6695 | 9 | 1 | 60 | |
| GSE54994 | SPOCK1 | 6695 | 3 | 13 | 37 | |
| GSE60625 | SPOCK1 | 6695 | 0 | 0 | 11 | |
| GSE74703 | SPOCK1 | 6695 | 3 | 5 | 28 | |
| GSE74704 | SPOCK1 | 6695 | 3 | 4 | 13 | |
| TCGA | SPOCK1 | 6695 | 4 | 36 | 56 |
Total number of gains: 33; Total number of losses: 133; Total Number of normals: 322.
Somatic mutations of SPOCK1:
Generating mutation plots.
Highly correlated genes for SPOCK1:
Showing top 20/1504 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SPOCK1 | WDR81 | 0.82694 | 3 | 0 | 3 |
| SPOCK1 | SLC45A1 | 0.807423 | 3 | 0 | 3 |
| SPOCK1 | FCGR3A | 0.784433 | 3 | 0 | 3 |
| SPOCK1 | FKBP7 | 0.76442 | 7 | 0 | 7 |
| SPOCK1 | STRADA | 0.760252 | 4 | 0 | 4 |
| SPOCK1 | NACC1 | 0.758494 | 3 | 0 | 3 |
| SPOCK1 | SMCR8 | 0.755258 | 3 | 0 | 3 |
| SPOCK1 | SCARA3 | 0.752572 | 3 | 0 | 3 |
| SPOCK1 | CLN5 | 0.748622 | 3 | 0 | 3 |
| SPOCK1 | RAB34 | 0.745828 | 3 | 0 | 3 |
| SPOCK1 | ZNF275 | 0.744704 | 6 | 0 | 6 |
| SPOCK1 | FSTL1 | 0.741483 | 13 | 0 | 13 |
| SPOCK1 | LINC00674 | 0.73635 | 3 | 0 | 3 |
| SPOCK1 | FADS1 | 0.730092 | 3 | 0 | 3 |
| SPOCK1 | CLSPN | 0.722502 | 3 | 0 | 3 |
| SPOCK1 | RHOU | 0.72154 | 3 | 0 | 3 |
| SPOCK1 | LRRC8C | 0.718421 | 3 | 0 | 3 |
| SPOCK1 | CHIC1 | 0.715627 | 4 | 0 | 4 |
| SPOCK1 | C2orf69 | 0.715531 | 3 | 0 | 3 |
| SPOCK1 | TMEM263 | 0.712749 | 7 | 0 | 7 |
For details and further investigation, click here
