| Full name: Fc fragment of IgG receptor IIIa | Alias Symbol: CD16|CD16a | ||
| Type: protein-coding gene | Cytoband: 1q23.3 | ||
| Entrez ID: 2214 | HGNC ID: HGNC:3619 | Ensembl Gene: ENSG00000203747 | OMIM ID: 146740 |
| Drug and gene relationship at DGIdb | |||
FCGR3A involved pathways:
Expression of FCGR3A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE53622 | FCGR3A | 2214 | 69630 | 1.9397 | 0.0000 | |
| GSE53624 | FCGR3A | 2214 | 69630 | 2.8822 | 0.0000 | |
| GSE97050 | FCGR3A | 2214 | A_23_P200728 | 0.8219 | 0.1852 | |
| SRP007169 | FCGR3A | 2214 | RNAseq | 6.0872 | 0.0000 | |
| SRP008496 | FCGR3A | 2214 | RNAseq | 5.3851 | 0.0000 | |
| SRP064894 | FCGR3A | 2214 | RNAseq | 2.9549 | 0.0000 | |
| SRP133303 | FCGR3A | 2214 | RNAseq | 3.0682 | 0.0000 | |
| SRP159526 | FCGR3A | 2214 | RNAseq | 3.0349 | 0.0000 | |
| SRP193095 | FCGR3A | 2214 | RNAseq | 2.6588 | 0.0000 | |
| SRP219564 | FCGR3A | 2214 | RNAseq | 3.4678 | 0.0018 | |
| TCGA | FCGR3A | 2214 | RNAseq | 1.0983 | 0.0000 |
Upregulated datasets: 10; Downregulated datasets: 0.
Survival by FCGR3A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of FCGR3A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | FCGR3A | 2214 | 10 | 0 | 20 | |
| GSE20123 | FCGR3A | 2214 | 10 | 0 | 20 | |
| GSE43470 | FCGR3A | 2214 | 7 | 2 | 34 | |
| GSE46452 | FCGR3A | 2214 | 2 | 1 | 56 | |
| GSE47630 | FCGR3A | 2214 | 14 | 0 | 26 | |
| GSE54993 | FCGR3A | 2214 | 0 | 5 | 65 | |
| GSE54994 | FCGR3A | 2214 | 16 | 0 | 37 | |
| GSE60625 | FCGR3A | 2214 | 0 | 0 | 11 | |
| GSE74703 | FCGR3A | 2214 | 7 | 2 | 27 | |
| GSE74704 | FCGR3A | 2214 | 4 | 0 | 16 | |
| TCGA | FCGR3A | 2214 | 43 | 4 | 49 |
Total number of gains: 113; Total number of losses: 14; Total Number of normals: 361.
Somatic mutations of FCGR3A:
Generating mutation plots.
Highly correlated genes for FCGR3A:
Showing top 20/552 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| FCGR3A | IGSF6 | 0.873832 | 3 | 0 | 3 |
| FCGR3A | TRAM2 | 0.864451 | 3 | 0 | 3 |
| FCGR3A | LHFPL2 | 0.861211 | 3 | 0 | 3 |
| FCGR3A | C5AR1 | 0.851464 | 3 | 0 | 3 |
| FCGR3A | CD14 | 0.844182 | 3 | 0 | 3 |
| FCGR3A | EMILIN2 | 0.843025 | 3 | 0 | 3 |
| FCGR3A | TNFAIP6 | 0.842764 | 3 | 0 | 3 |
| FCGR3A | BCL2A1 | 0.837625 | 3 | 0 | 3 |
| FCGR3A | TYROBP | 0.835695 | 3 | 0 | 3 |
| FCGR3A | CD163 | 0.833436 | 3 | 0 | 3 |
| FCGR3A | LILRB2 | 0.831964 | 3 | 0 | 3 |
| FCGR3A | TLR2 | 0.831691 | 3 | 0 | 3 |
| FCGR3A | DRAM1 | 0.828196 | 3 | 0 | 3 |
| FCGR3A | CTSZ | 0.821165 | 3 | 0 | 3 |
| FCGR3A | C1QA | 0.820204 | 3 | 0 | 3 |
| FCGR3A | CCR1 | 0.809154 | 3 | 0 | 3 |
| FCGR3A | GNA12 | 0.808948 | 3 | 0 | 3 |
| FCGR3A | SH2B3 | 0.807128 | 3 | 0 | 3 |
| FCGR3A | C3AR1 | 0.804808 | 3 | 0 | 3 |
| FCGR3A | CHN1 | 0.804201 | 3 | 0 | 3 |
For details and further investigation, click here
