| Full name: SMCR8-C9orf72 complex subunit | Alias Symbol: FLJ34716|DENND8A | ||
| Type: protein-coding gene | Cytoband: 17p11.2 | ||
| Entrez ID: 140775 | HGNC ID: HGNC:17921 | Ensembl Gene: ENSG00000176994 | OMIM ID: 617074 |
| Drug and gene relationship at DGIdb | |||
Expression of SMCR8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SMCR8 | 140775 | 227305_s_at | 0.3978 | 0.1750 | |
| GSE26886 | SMCR8 | 140775 | 227305_s_at | 0.4279 | 0.0226 | |
| GSE45670 | SMCR8 | 140775 | 227305_s_at | 0.3021 | 0.0082 | |
| GSE53622 | SMCR8 | 140775 | 53090 | 0.3256 | 0.0000 | |
| GSE53624 | SMCR8 | 140775 | 53090 | 0.3634 | 0.0000 | |
| GSE63941 | SMCR8 | 140775 | 227305_s_at | 0.2446 | 0.6588 | |
| GSE77861 | SMCR8 | 140775 | 227305_s_at | 0.6052 | 0.0009 | |
| GSE97050 | SMCR8 | 140775 | A_23_P300124 | 0.2704 | 0.3720 | |
| SRP007169 | SMCR8 | 140775 | RNAseq | 0.2793 | 0.4473 | |
| SRP008496 | SMCR8 | 140775 | RNAseq | -0.0310 | 0.8989 | |
| SRP064894 | SMCR8 | 140775 | RNAseq | 0.2466 | 0.3393 | |
| SRP133303 | SMCR8 | 140775 | RNAseq | 0.2153 | 0.1571 | |
| SRP159526 | SMCR8 | 140775 | RNAseq | -0.1944 | 0.5410 | |
| SRP193095 | SMCR8 | 140775 | RNAseq | 0.0582 | 0.5143 | |
| SRP219564 | SMCR8 | 140775 | RNAseq | 0.4205 | 0.1968 | |
| TCGA | SMCR8 | 140775 | RNAseq | -0.1104 | 0.0255 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SMCR8 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SMCR8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SMCR8 | 140775 | 3 | 3 | 24 | |
| GSE20123 | SMCR8 | 140775 | 3 | 4 | 23 | |
| GSE43470 | SMCR8 | 140775 | 1 | 5 | 37 | |
| GSE46452 | SMCR8 | 140775 | 34 | 1 | 24 | |
| GSE47630 | SMCR8 | 140775 | 7 | 1 | 32 | |
| GSE54993 | SMCR8 | 140775 | 3 | 3 | 64 | |
| GSE54994 | SMCR8 | 140775 | 6 | 6 | 41 | |
| GSE60625 | SMCR8 | 140775 | 4 | 0 | 7 | |
| GSE74703 | SMCR8 | 140775 | 1 | 2 | 33 | |
| GSE74704 | SMCR8 | 140775 | 2 | 1 | 17 | |
| TCGA | SMCR8 | 140775 | 19 | 23 | 54 |
Total number of gains: 83; Total number of losses: 49; Total Number of normals: 356.
Somatic mutations of SMCR8:
Generating mutation plots.
Highly correlated genes for SMCR8:
Showing top 20/1289 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SMCR8 | RAD21 | 0.843407 | 3 | 0 | 3 |
| SMCR8 | DDB1 | 0.832007 | 3 | 0 | 3 |
| SMCR8 | METTL5 | 0.831193 | 3 | 0 | 3 |
| SMCR8 | HNRNPR | 0.828126 | 3 | 0 | 3 |
| SMCR8 | KLHL13 | 0.825317 | 3 | 0 | 3 |
| SMCR8 | C12orf49 | 0.816405 | 3 | 0 | 3 |
| SMCR8 | AGPAT5 | 0.80711 | 3 | 0 | 3 |
| SMCR8 | CASC4 | 0.800981 | 3 | 0 | 3 |
| SMCR8 | NIN | 0.800379 | 4 | 0 | 4 |
| SMCR8 | KLHL7 | 0.798613 | 3 | 0 | 3 |
| SMCR8 | MACF1 | 0.796396 | 3 | 0 | 3 |
| SMCR8 | TOMM20 | 0.786357 | 4 | 0 | 4 |
| SMCR8 | STK4 | 0.784399 | 3 | 0 | 3 |
| SMCR8 | ERGIC3 | 0.783555 | 3 | 0 | 3 |
| SMCR8 | ADCY3 | 0.783201 | 3 | 0 | 3 |
| SMCR8 | EZH2 | 0.782901 | 3 | 0 | 3 |
| SMCR8 | GSR | 0.782274 | 3 | 0 | 3 |
| SMCR8 | TAF11 | 0.780757 | 3 | 0 | 3 |
| SMCR8 | ZBED1 | 0.780472 | 3 | 0 | 3 |
| SMCR8 | SBNO1 | 0.778139 | 3 | 0 | 3 |
For details and further investigation, click here
