| Full name: CLN5 intracellular trafficking protein | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 13q22.3 | ||
| Entrez ID: 1203 | HGNC ID: HGNC:2076 | Ensembl Gene: ENSG00000102805 | OMIM ID: 608102 |
| Drug and gene relationship at DGIdb | |||
Expression of CLN5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CLN5 | 1203 | 204084_s_at | -0.0403 | 0.9466 | |
| GSE20347 | CLN5 | 1203 | 204084_s_at | -0.3519 | 0.1453 | |
| GSE23400 | CLN5 | 1203 | 204084_s_at | 0.1729 | 0.0480 | |
| GSE26886 | CLN5 | 1203 | 204084_s_at | 0.8987 | 0.0026 | |
| GSE29001 | CLN5 | 1203 | 204084_s_at | 0.3033 | 0.4349 | |
| GSE38129 | CLN5 | 1203 | 204084_s_at | -0.2967 | 0.1323 | |
| GSE45670 | CLN5 | 1203 | 204084_s_at | 0.2612 | 0.2179 | |
| GSE53622 | CLN5 | 1203 | 55077 | -0.0722 | 0.5371 | |
| GSE53624 | CLN5 | 1203 | 55077 | 0.1681 | 0.1173 | |
| GSE63941 | CLN5 | 1203 | 204084_s_at | -1.8059 | 0.0005 | |
| GSE77861 | CLN5 | 1203 | 204084_s_at | 0.0504 | 0.8994 | |
| GSE97050 | CLN5 | 1203 | A_33_P3365805 | -0.1579 | 0.4869 | |
| SRP007169 | CLN5 | 1203 | RNAseq | 0.0206 | 0.9551 | |
| SRP008496 | CLN5 | 1203 | RNAseq | 0.1535 | 0.5739 | |
| SRP064894 | CLN5 | 1203 | RNAseq | 0.3435 | 0.0159 | |
| SRP133303 | CLN5 | 1203 | RNAseq | 0.4038 | 0.1270 | |
| SRP159526 | CLN5 | 1203 | RNAseq | -0.1968 | 0.5948 | |
| SRP193095 | CLN5 | 1203 | RNAseq | -0.0796 | 0.5209 | |
| SRP219564 | CLN5 | 1203 | RNAseq | 0.3255 | 0.2933 | |
| TCGA | CLN5 | 1203 | RNAseq | -0.1885 | 0.0013 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by CLN5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CLN5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CLN5 | 1203 | 3 | 11 | 16 | |
| GSE20123 | CLN5 | 1203 | 3 | 10 | 17 | |
| GSE43470 | CLN5 | 1203 | 4 | 11 | 28 | |
| GSE46452 | CLN5 | 1203 | 0 | 32 | 27 | |
| GSE47630 | CLN5 | 1203 | 3 | 27 | 10 | |
| GSE54993 | CLN5 | 1203 | 11 | 3 | 56 | |
| GSE54994 | CLN5 | 1203 | 3 | 15 | 35 | |
| GSE60625 | CLN5 | 1203 | 0 | 3 | 8 | |
| GSE74703 | CLN5 | 1203 | 3 | 9 | 24 | |
| GSE74704 | CLN5 | 1203 | 1 | 9 | 10 | |
| TCGA | CLN5 | 1203 | 12 | 33 | 51 |
Total number of gains: 43; Total number of losses: 163; Total Number of normals: 282.
Somatic mutations of CLN5:
Generating mutation plots.
Highly correlated genes for CLN5:
Showing top 20/521 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CLN5 | FBXL3 | 0.777633 | 3 | 0 | 3 |
| CLN5 | SPOCK1 | 0.748622 | 3 | 0 | 3 |
| CLN5 | LARP6 | 0.739602 | 3 | 0 | 3 |
| CLN5 | PLEKHH2 | 0.735087 | 3 | 0 | 3 |
| CLN5 | TWSG1 | 0.73408 | 4 | 0 | 3 |
| CLN5 | PMPCB | 0.728011 | 3 | 0 | 3 |
| CLN5 | MZT1 | 0.724379 | 3 | 0 | 3 |
| CLN5 | MRPL19 | 0.717891 | 3 | 0 | 3 |
| CLN5 | CMC1 | 0.714444 | 3 | 0 | 3 |
| CLN5 | SSBP4 | 0.70778 | 3 | 0 | 3 |
| CLN5 | CCDC59 | 0.703991 | 3 | 0 | 3 |
| CLN5 | MNAT1 | 0.703492 | 4 | 0 | 3 |
| CLN5 | ZNF225 | 0.698737 | 3 | 0 | 3 |
| CLN5 | RAB28 | 0.695662 | 3 | 0 | 3 |
| CLN5 | SLC7A6OS | 0.69256 | 3 | 0 | 3 |
| CLN5 | NTPCR | 0.689245 | 3 | 0 | 3 |
| CLN5 | SEC22A | 0.688592 | 4 | 0 | 4 |
| CLN5 | NUP54 | 0.687669 | 3 | 0 | 3 |
| CLN5 | PPARA | 0.687559 | 3 | 0 | 3 |
| CLN5 | GCSH | 0.683625 | 3 | 0 | 3 |
For details and further investigation, click here
