| Full name: leucine rich repeat containing 8 VRAC subunit C | Alias Symbol: AD158 | ||
| Type: protein-coding gene | Cytoband: 1p22.2 | ||
| Entrez ID: 84230 | HGNC ID: HGNC:25075 | Ensembl Gene: ENSG00000171488 | OMIM ID: 612889 |
| Drug and gene relationship at DGIdb | |||
Expression of LRRC8C:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE53622 | LRRC8C | 84230 | 99549 | 0.7806 | 0.0000 | |
| GSE53624 | LRRC8C | 84230 | 99549 | 1.3608 | 0.0000 | |
| GSE97050 | LRRC8C | 84230 | A_33_P3406030 | 0.8892 | 0.0608 | |
| SRP007169 | LRRC8C | 84230 | RNAseq | 2.5745 | 0.0000 | |
| SRP008496 | LRRC8C | 84230 | RNAseq | 2.7140 | 0.0000 | |
| SRP064894 | LRRC8C | 84230 | RNAseq | 1.2396 | 0.0000 | |
| SRP133303 | LRRC8C | 84230 | RNAseq | 0.9839 | 0.0000 | |
| SRP159526 | LRRC8C | 84230 | RNAseq | 0.4103 | 0.1984 | |
| SRP193095 | LRRC8C | 84230 | RNAseq | 1.5189 | 0.0000 | |
| SRP219564 | LRRC8C | 84230 | RNAseq | 0.8131 | 0.1272 | |
| TCGA | LRRC8C | 84230 | RNAseq | 0.1902 | 0.0332 |
Upregulated datasets: 5; Downregulated datasets: 0.
Survival by LRRC8C expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LRRC8C:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LRRC8C | 84230 | 0 | 8 | 22 | |
| GSE20123 | LRRC8C | 84230 | 0 | 8 | 22 | |
| GSE43470 | LRRC8C | 84230 | 2 | 3 | 38 | |
| GSE46452 | LRRC8C | 84230 | 1 | 1 | 57 | |
| GSE47630 | LRRC8C | 84230 | 8 | 5 | 27 | |
| GSE54993 | LRRC8C | 84230 | 0 | 1 | 69 | |
| GSE54994 | LRRC8C | 84230 | 6 | 2 | 45 | |
| GSE60625 | LRRC8C | 84230 | 0 | 0 | 11 | |
| GSE74703 | LRRC8C | 84230 | 1 | 3 | 32 | |
| GSE74704 | LRRC8C | 84230 | 0 | 5 | 15 | |
| TCGA | LRRC8C | 84230 | 6 | 22 | 68 |
Total number of gains: 24; Total number of losses: 58; Total Number of normals: 406.
Somatic mutations of LRRC8C:
Generating mutation plots.
Highly correlated genes for LRRC8C:
Showing top 20/561 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LRRC8C | GNA12 | 0.822214 | 3 | 0 | 3 |
| LRRC8C | TNFAIP6 | 0.810497 | 3 | 0 | 3 |
| LRRC8C | CD14 | 0.80579 | 3 | 0 | 3 |
| LRRC8C | YWHAH | 0.802397 | 3 | 0 | 3 |
| LRRC8C | LPCAT1 | 0.802025 | 3 | 0 | 3 |
| LRRC8C | FMNL3 | 0.799782 | 3 | 0 | 3 |
| LRRC8C | SH3PXD2B | 0.797296 | 3 | 0 | 3 |
| LRRC8C | RAB31 | 0.78831 | 3 | 0 | 3 |
| LRRC8C | ACVR1 | 0.786351 | 3 | 0 | 3 |
| LRRC8C | DRAM1 | 0.784505 | 3 | 0 | 3 |
| LRRC8C | PRR16 | 0.784386 | 3 | 0 | 3 |
| LRRC8C | PRSS23 | 0.783763 | 3 | 0 | 3 |
| LRRC8C | RGS3 | 0.783333 | 3 | 0 | 3 |
| LRRC8C | AHR | 0.783291 | 3 | 0 | 3 |
| LRRC8C | ZNF469 | 0.783057 | 3 | 0 | 3 |
| LRRC8C | GPX8 | 0.782349 | 3 | 0 | 3 |
| LRRC8C | CTSK | 0.780207 | 3 | 0 | 3 |
| LRRC8C | TLR2 | 0.780081 | 3 | 0 | 3 |
| LRRC8C | AMIGO2 | 0.779198 | 3 | 0 | 3 |
| LRRC8C | MYO5A | 0.779118 | 3 | 0 | 3 |
For details and further investigation, click here
