| Full name: sterol regulatory element binding transcription factor 1 | Alias Symbol: SREBP1|bHLHd1|SREBP-1c|SREBP1a | ||
| Type: protein-coding gene | Cytoband: 17p11.2 | ||
| Entrez ID: 6720 | HGNC ID: HGNC:11289 | Ensembl Gene: ENSG00000072310 | OMIM ID: 184756 |
Screen Evidence:
| |||
SREBF1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04152 | AMPK signaling pathway | |
| hsa04910 | Insulin signaling pathway | |
| hsa04931 | Insulin resistance | |
| hsa04932 | Non-alcoholic fatty liver disease (NAFLD) |
Expression of SREBF1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SREBF1 | 6720 | 202308_at | 0.6166 | 0.3134 | |
| GSE20347 | SREBF1 | 6720 | 202308_at | 0.6436 | 0.0014 | |
| GSE23400 | SREBF1 | 6720 | 202308_at | 0.4071 | 0.0000 | |
| GSE26886 | SREBF1 | 6720 | 202308_at | 0.4317 | 0.0637 | |
| GSE29001 | SREBF1 | 6720 | 202308_at | 0.5633 | 0.0195 | |
| GSE38129 | SREBF1 | 6720 | 202308_at | 0.6454 | 0.0002 | |
| GSE45670 | SREBF1 | 6720 | 202308_at | 0.8956 | 0.0006 | |
| GSE53622 | SREBF1 | 6720 | 43179 | 0.1330 | 0.2797 | |
| GSE53624 | SREBF1 | 6720 | 43179 | 0.4290 | 0.0000 | |
| GSE63941 | SREBF1 | 6720 | 202308_at | 0.8132 | 0.2657 | |
| GSE77861 | SREBF1 | 6720 | 202308_at | 0.3156 | 0.2494 | |
| GSE97050 | SREBF1 | 6720 | A_23_P129786 | 0.1640 | 0.6757 | |
| SRP007169 | SREBF1 | 6720 | RNAseq | 0.4391 | 0.2911 | |
| SRP008496 | SREBF1 | 6720 | RNAseq | -0.0665 | 0.8561 | |
| SRP064894 | SREBF1 | 6720 | RNAseq | 0.5149 | 0.0870 | |
| SRP133303 | SREBF1 | 6720 | RNAseq | 0.5025 | 0.0928 | |
| SRP159526 | SREBF1 | 6720 | RNAseq | 1.1543 | 0.0000 | |
| SRP193095 | SREBF1 | 6720 | RNAseq | 0.5946 | 0.0005 | |
| SRP219564 | SREBF1 | 6720 | RNAseq | 1.1664 | 0.0074 | |
| TCGA | SREBF1 | 6720 | RNAseq | 0.3302 | 0.0000 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by SREBF1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SREBF1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SREBF1 | 6720 | 3 | 3 | 24 | |
| GSE20123 | SREBF1 | 6720 | 3 | 4 | 23 | |
| GSE43470 | SREBF1 | 6720 | 1 | 5 | 37 | |
| GSE46452 | SREBF1 | 6720 | 34 | 1 | 24 | |
| GSE47630 | SREBF1 | 6720 | 7 | 1 | 32 | |
| GSE54993 | SREBF1 | 6720 | 3 | 3 | 64 | |
| GSE54994 | SREBF1 | 6720 | 6 | 6 | 41 | |
| GSE60625 | SREBF1 | 6720 | 4 | 0 | 7 | |
| GSE74703 | SREBF1 | 6720 | 1 | 2 | 33 | |
| GSE74704 | SREBF1 | 6720 | 2 | 1 | 17 | |
| TCGA | SREBF1 | 6720 | 18 | 23 | 55 |
Total number of gains: 82; Total number of losses: 49; Total Number of normals: 357.
Somatic mutations of SREBF1:
Generating mutation plots.
Highly correlated genes for SREBF1:
Showing top 20/590 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SREBF1 | BCL9L | 0.8526 | 3 | 0 | 3 |
| SREBF1 | KRTCAP2 | 0.795868 | 3 | 0 | 3 |
| SREBF1 | ZNF317 | 0.75767 | 3 | 0 | 3 |
| SREBF1 | HNRNPAB | 0.752267 | 3 | 0 | 3 |
| SREBF1 | PSPC1 | 0.747225 | 4 | 0 | 4 |
| SREBF1 | RBMS1 | 0.725745 | 3 | 0 | 3 |
| SREBF1 | DHX36 | 0.725738 | 3 | 0 | 3 |
| SREBF1 | NENF | 0.722883 | 3 | 0 | 3 |
| SREBF1 | ZNF251 | 0.714922 | 3 | 0 | 3 |
| SREBF1 | CNNM3 | 0.714535 | 3 | 0 | 3 |
| SREBF1 | GEN1 | 0.714234 | 3 | 0 | 3 |
| SREBF1 | HCFC1 | 0.713072 | 3 | 0 | 3 |
| SREBF1 | IFRD2 | 0.711593 | 4 | 0 | 3 |
| SREBF1 | C1orf131 | 0.711226 | 4 | 0 | 4 |
| SREBF1 | C12orf45 | 0.706914 | 3 | 0 | 3 |
| SREBF1 | PIK3R3 | 0.697423 | 3 | 0 | 3 |
| SREBF1 | GOSR1 | 0.696058 | 3 | 0 | 3 |
| SREBF1 | MTCP1 | 0.695748 | 4 | 0 | 4 |
| SREBF1 | RRP9 | 0.690462 | 3 | 0 | 3 |
| SREBF1 | URM1 | 0.689842 | 3 | 0 | 3 |
For details and further investigation, click here
