ZNF317

 

Full name: zinc finger protein 317 Alias Symbol: 
Type: protein-coding gene Cytoband: 19p13
Entrez ID: 57693 HGNC ID: HGNC:13507 Ensembl Gene: ENSG00000130803 OMIM ID: 613864
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of ZNF317:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 ZNF317 57693 225296_at 0.2007 0.5957
GSE26886 ZNF317 57693 225296_at 0.0624 0.8412
GSE45670 ZNF317 57693 225296_at 0.4091 0.0007
GSE53622 ZNF317 57693 134656 0.1528 0.0113
GSE53624 ZNF317 57693 134656 0.3974 0.0000
GSE63941 ZNF317 57693 225296_at 0.3570 0.2807
GSE77861 ZNF317 57693 225296_at 0.4106 0.0131
GSE97050 ZNF317 57693 A_24_P258955 0.1423 0.6102
SRP007169 ZNF317 57693 RNAseq 0.7718 0.0419
SRP008496 ZNF317 57693 RNAseq 0.7690 0.0054
SRP064894 ZNF317 57693 RNAseq 0.3713 0.0016
SRP133303 ZNF317 57693 RNAseq 0.2385 0.0701
SRP159526 ZNF317 57693 RNAseq 0.1177 0.6179
SRP193095 ZNF317 57693 RNAseq 0.1904 0.0280
SRP219564 ZNF317 57693 RNAseq 0.3263 0.1568
TCGA ZNF317 57693 RNAseq -0.0642 0.1806

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by ZNF317 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of ZNF317:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 ZNF317 57693 4 2 24
GSE20123 ZNF317 57693 3 1 26
GSE43470 ZNF317 57693 3 5 35
GSE46452 ZNF317 57693 47 1 11
GSE47630 ZNF317 57693 5 7 28
GSE54993 ZNF317 57693 16 3 51
GSE54994 ZNF317 57693 6 14 33
GSE60625 ZNF317 57693 9 0 2
GSE74703 ZNF317 57693 3 4 29
GSE74704 ZNF317 57693 0 1 19
TCGA ZNF317 57693 10 19 67

Total number of gains: 106; Total number of losses: 57; Total Number of normals: 325.  

 

Somatic mutations of ZNF317:

 

Generating mutation plots.

 

Highly correlated genes for ZNF317:

 

Showing top 20/1264 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
ZNF317ZNF5640.82599303
ZNF317EWSR10.823513303
ZNF317ATG4C0.823163303
ZNF317USP340.806485303
ZNF317HNRNPM0.801784404
ZNF317EEF1D0.79988303
ZNF317MCM50.799743303
ZNF317RAD180.798215303
ZNF317LSM40.797424404
ZNF317SNRPG0.797028303
ZNF317HNRNPC0.796643303
ZNF317ACP60.792845303
ZNF317RAD23A0.792074505
ZNF317ZNF4960.788182303
ZNF317ARTN0.78277303
ZNF317SRSF60.781298404
ZNF317STK30.779279303
ZNF317LGALS80.778481303
ZNF317CHML0.775563303
ZNF317PIK3R30.774202303

For details and further investigation, click here