C12orf45

 

Full name: chromosome 12 open reading frame 45 Alias Symbol: MGC40397
Type: protein-coding gene Cytoband: 12q23.3
Entrez ID: 121053 HGNC ID: HGNC:28628 Ensembl Gene: ENSG00000151131 OMIM ID: 
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of C12orf45:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 C12orf45 121053 226349_at 0.4222 0.1311
GSE26886 C12orf45 121053 226349_at 1.0811 0.0001
GSE45670 C12orf45 121053 226349_at 0.2857 0.0412
GSE53622 C12orf45 121053 30373 0.5165 0.0000
GSE53624 C12orf45 121053 30373 0.7422 0.0000
GSE63941 C12orf45 121053 226349_at 1.3480 0.0016
GSE77861 C12orf45 121053 226349_at 0.1474 0.1941
GSE97050 C12orf45 121053 A_23_P128532 0.2880 0.4534
SRP007169 C12orf45 121053 RNAseq 0.8920 0.0096
SRP008496 C12orf45 121053 RNAseq 0.8690 0.0002
SRP064894 C12orf45 121053 RNAseq 0.0818 0.5672
SRP133303 C12orf45 121053 RNAseq 0.1525 0.1364
SRP159526 C12orf45 121053 RNAseq 0.4451 0.0996
SRP193095 C12orf45 121053 RNAseq 0.3165 0.0181
SRP219564 C12orf45 121053 RNAseq 0.0408 0.8873
TCGA C12orf45 121053 RNAseq 0.1722 0.0703

Upregulated datasets: 2; Downregulated datasets: 0.  

 

Survival by C12orf45 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of C12orf45:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 C12orf45 121053 4 2 24
GSE20123 C12orf45 121053 4 2 24
GSE43470 C12orf45 121053 2 0 41
GSE46452 C12orf45 121053 9 1 49
GSE47630 C12orf45 121053 9 1 30
GSE54993 C12orf45 121053 0 5 65
GSE54994 C12orf45 121053 4 2 47
GSE60625 C12orf45 121053 0 0 11
GSE74703 C12orf45 121053 2 0 34
GSE74704 C12orf45 121053 1 2 17
TCGA C12orf45 121053 19 10 67

Total number of gains: 54; Total number of losses: 25; Total Number of normals: 409.  

 

Somatic mutations of C12orf45:

 

Generating mutation plots.

 

Highly correlated genes for C12orf45:

 

Showing top 20/1353 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
C12orf45PPP1R16A0.863331303
C12orf45TFDP20.80155303
C12orf45GTPBP80.799647303
C12orf45NENF0.792642404
C12orf45SLC39A30.788755404
C12orf45ZNF5840.782737303
C12orf45UBAP2L0.777852303
C12orf45ZNF4080.772592303
C12orf45RBM12B0.769913303
C12orf45SMARCA50.766126303
C12orf45SARS20.764923303
C12orf45ASNSD10.764533303
C12orf45ROMO10.755257303
C12orf45VAPB0.754723303
C12orf45EIF2S10.753007303
C12orf45PTGES20.748448303
C12orf45CXXC10.747924303
C12orf45POLR2K0.743181404
C12orf45TERF20.73979303
C12orf45CPLX10.739393303

For details and further investigation, click here