| Full name: paraspeckle component 1 | Alias Symbol: PSP1|FLJ10955 | ||
| Type: protein-coding gene | Cytoband: 13q12.11 | ||
| Entrez ID: 55269 | HGNC ID: HGNC:20320 | Ensembl Gene: ENSG00000121390 | OMIM ID: 612408 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of PSPC1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PSPC1 | 55269 | 226574_at | 0.5268 | 0.2143 | |
| GSE20347 | PSPC1 | 55269 | 218371_s_at | -0.0134 | 0.9533 | |
| GSE23400 | PSPC1 | 55269 | 218371_s_at | 0.3052 | 0.0000 | |
| GSE26886 | PSPC1 | 55269 | 226574_at | 0.4334 | 0.0568 | |
| GSE29001 | PSPC1 | 55269 | 218371_s_at | 0.3178 | 0.2746 | |
| GSE38129 | PSPC1 | 55269 | 218371_s_at | 0.0731 | 0.6933 | |
| GSE45670 | PSPC1 | 55269 | 226574_at | 0.6599 | 0.0149 | |
| GSE53622 | PSPC1 | 55269 | 55764 | 0.2176 | 0.0007 | |
| GSE53624 | PSPC1 | 55269 | 55764 | 0.2410 | 0.0000 | |
| GSE63941 | PSPC1 | 55269 | 226574_at | -0.2538 | 0.5875 | |
| GSE77861 | PSPC1 | 55269 | 226574_at | 0.5467 | 0.0154 | |
| GSE97050 | PSPC1 | 55269 | A_33_P3313555 | 0.3419 | 0.2731 | |
| SRP007169 | PSPC1 | 55269 | RNAseq | 0.8461 | 0.0801 | |
| SRP008496 | PSPC1 | 55269 | RNAseq | 0.9345 | 0.0137 | |
| SRP064894 | PSPC1 | 55269 | RNAseq | 0.4138 | 0.0139 | |
| SRP133303 | PSPC1 | 55269 | RNAseq | 0.1268 | 0.6011 | |
| SRP159526 | PSPC1 | 55269 | RNAseq | 0.1790 | 0.3773 | |
| SRP193095 | PSPC1 | 55269 | RNAseq | 0.2531 | 0.0089 | |
| SRP219564 | PSPC1 | 55269 | RNAseq | -0.2444 | 0.3770 | |
| TCGA | PSPC1 | 55269 | RNAseq | 0.0751 | 0.1742 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by PSPC1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PSPC1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PSPC1 | 55269 | 1 | 16 | 13 | |
| GSE20123 | PSPC1 | 55269 | 1 | 15 | 14 | |
| GSE43470 | PSPC1 | 55269 | 1 | 13 | 29 | |
| GSE46452 | PSPC1 | 55269 | 0 | 33 | 26 | |
| GSE47630 | PSPC1 | 55269 | 3 | 26 | 11 | |
| GSE54993 | PSPC1 | 55269 | 11 | 2 | 57 | |
| GSE54994 | PSPC1 | 55269 | 1 | 13 | 39 | |
| GSE60625 | PSPC1 | 55269 | 0 | 3 | 8 | |
| GSE74703 | PSPC1 | 55269 | 1 | 10 | 25 | |
| GSE74704 | PSPC1 | 55269 | 0 | 13 | 7 | |
| TCGA | PSPC1 | 55269 | 7 | 43 | 46 |
Total number of gains: 26; Total number of losses: 187; Total Number of normals: 275.
Somatic mutations of PSPC1:
Generating mutation plots.
Highly correlated genes for PSPC1:
Showing top 20/1059 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PSPC1 | ITGA3 | 0.80677 | 3 | 0 | 3 |
| PSPC1 | CMIP | 0.800818 | 3 | 0 | 3 |
| PSPC1 | TPM3 | 0.792541 | 3 | 0 | 3 |
| PSPC1 | FAM86C1 | 0.792121 | 3 | 0 | 3 |
| PSPC1 | TRIM59 | 0.774383 | 4 | 0 | 4 |
| PSPC1 | ZNF121 | 0.772306 | 3 | 0 | 3 |
| PSPC1 | IFI16 | 0.767487 | 4 | 0 | 4 |
| PSPC1 | TRMT12 | 0.763878 | 3 | 0 | 3 |
| PSPC1 | DOCK6 | 0.757878 | 3 | 0 | 3 |
| PSPC1 | FBXL6 | 0.755942 | 3 | 0 | 3 |
| PSPC1 | FBLIM1 | 0.755017 | 3 | 0 | 3 |
| PSPC1 | ABCF2 | 0.75022 | 4 | 0 | 4 |
| PSPC1 | GSPT1 | 0.747586 | 3 | 0 | 3 |
| PSPC1 | SREBF1 | 0.747225 | 4 | 0 | 4 |
| PSPC1 | SAMD1 | 0.744696 | 3 | 0 | 3 |
| PSPC1 | RNF26 | 0.743064 | 3 | 0 | 3 |
| PSPC1 | FAM32A | 0.737807 | 4 | 0 | 4 |
| PSPC1 | SNX4 | 0.737714 | 3 | 0 | 3 |
| PSPC1 | TRAF3 | 0.737342 | 4 | 0 | 4 |
| PSPC1 | PPP1R10 | 0.735116 | 3 | 0 | 3 |
For details and further investigation, click here
