| Full name: SLIT-ROBO Rho GTPase activating protein 1 | Alias Symbol: KIAA1304|ARHGAP13 | ||
| Type: protein-coding gene | Cytoband: 12q14.2 | ||
| Entrez ID: 57522 | HGNC ID: HGNC:17382 | Ensembl Gene: ENSG00000196935 | OMIM ID: 606523 |
| Drug and gene relationship at DGIdb | |||
SRGAP1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04360 | Axon guidance |
Expression of SRGAP1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SRGAP1 | 57522 | 233888_s_at | 0.1228 | 0.8950 | |
| GSE26886 | SRGAP1 | 57522 | 233888_s_at | -0.3240 | 0.3837 | |
| GSE45670 | SRGAP1 | 57522 | 227484_at | -0.1375 | 0.5697 | |
| GSE53622 | SRGAP1 | 57522 | 37768 | 0.0435 | 0.6286 | |
| GSE53624 | SRGAP1 | 57522 | 37768 | -0.1154 | 0.1201 | |
| GSE63941 | SRGAP1 | 57522 | 233888_s_at | 0.4280 | 0.3348 | |
| GSE77861 | SRGAP1 | 57522 | 233888_s_at | -0.0541 | 0.8637 | |
| GSE97050 | SRGAP1 | 57522 | A_23_P162449 | 0.0170 | 0.9469 | |
| SRP007169 | SRGAP1 | 57522 | RNAseq | -0.5817 | 0.1872 | |
| SRP008496 | SRGAP1 | 57522 | RNAseq | -0.4376 | 0.1909 | |
| SRP064894 | SRGAP1 | 57522 | RNAseq | -0.2025 | 0.3684 | |
| SRP133303 | SRGAP1 | 57522 | RNAseq | 0.4228 | 0.0189 | |
| SRP159526 | SRGAP1 | 57522 | RNAseq | 0.0105 | 0.9805 | |
| SRP193095 | SRGAP1 | 57522 | RNAseq | 0.0057 | 0.9658 | |
| SRP219564 | SRGAP1 | 57522 | RNAseq | 0.4935 | 0.1229 | |
| TCGA | SRGAP1 | 57522 | RNAseq | 0.0620 | 0.4936 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SRGAP1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SRGAP1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SRGAP1 | 57522 | 4 | 1 | 25 | |
| GSE20123 | SRGAP1 | 57522 | 4 | 1 | 25 | |
| GSE43470 | SRGAP1 | 57522 | 4 | 0 | 39 | |
| GSE46452 | SRGAP1 | 57522 | 10 | 0 | 49 | |
| GSE47630 | SRGAP1 | 57522 | 10 | 2 | 28 | |
| GSE54993 | SRGAP1 | 57522 | 0 | 5 | 65 | |
| GSE54994 | SRGAP1 | 57522 | 7 | 1 | 45 | |
| GSE60625 | SRGAP1 | 57522 | 0 | 0 | 11 | |
| GSE74703 | SRGAP1 | 57522 | 4 | 0 | 32 | |
| GSE74704 | SRGAP1 | 57522 | 3 | 1 | 16 | |
| TCGA | SRGAP1 | 57522 | 19 | 11 | 66 |
Total number of gains: 65; Total number of losses: 22; Total Number of normals: 401.
Somatic mutations of SRGAP1:
Generating mutation plots.
Highly correlated genes for SRGAP1:
Showing top 20/39 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SRGAP1 | DUT | 0.761297 | 3 | 0 | 3 |
| SRGAP1 | C1orf174 | 0.761127 | 3 | 0 | 3 |
| SRGAP1 | RBM4 | 0.746958 | 3 | 0 | 3 |
| SRGAP1 | RPA2 | 0.745715 | 3 | 0 | 3 |
| SRGAP1 | ARMCX6 | 0.737034 | 3 | 0 | 3 |
| SRGAP1 | FAM111B | 0.725743 | 3 | 0 | 3 |
| SRGAP1 | E2F8 | 0.723241 | 3 | 0 | 3 |
| SRGAP1 | RBBP7 | 0.720848 | 3 | 0 | 3 |
| SRGAP1 | MTMR12 | 0.720143 | 3 | 0 | 3 |
| SRGAP1 | MECOM | 0.71316 | 3 | 0 | 3 |
| SRGAP1 | OS9 | 0.707579 | 3 | 0 | 3 |
| SRGAP1 | FGD4 | 0.70335 | 3 | 0 | 3 |
| SRGAP1 | FGFR1OP | 0.699478 | 3 | 0 | 3 |
| SRGAP1 | ZNF92 | 0.698496 | 4 | 0 | 3 |
| SRGAP1 | SRI | 0.698444 | 3 | 0 | 3 |
| SRGAP1 | ZNF704 | 0.695446 | 3 | 0 | 3 |
| SRGAP1 | ZNF490 | 0.694273 | 3 | 0 | 3 |
| SRGAP1 | HNRNPF | 0.679578 | 3 | 0 | 3 |
| SRGAP1 | ZNHIT6 | 0.67753 | 3 | 0 | 3 |
| SRGAP1 | CREB1 | 0.665965 | 3 | 0 | 3 |
For details and further investigation, click here
