| Full name: replication protein A2 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 1p35.3 | ||
| Entrez ID: 6118 | HGNC ID: HGNC:10290 | Ensembl Gene: ENSG00000117748 | OMIM ID: 179836 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of RPA2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RPA2 | 6118 | 201756_at | 0.2411 | 0.5263 | |
| GSE20347 | RPA2 | 6118 | 201756_at | 0.2828 | 0.0876 | |
| GSE23400 | RPA2 | 6118 | 201756_at | 0.3362 | 0.0000 | |
| GSE26886 | RPA2 | 6118 | 201756_at | -0.3532 | 0.1903 | |
| GSE29001 | RPA2 | 6118 | 201756_at | 0.4413 | 0.1292 | |
| GSE38129 | RPA2 | 6118 | 201756_at | 0.2853 | 0.1150 | |
| GSE45670 | RPA2 | 6118 | 201756_at | 0.1250 | 0.4531 | |
| GSE53622 | RPA2 | 6118 | 81141 | 0.1267 | 0.0874 | |
| GSE53624 | RPA2 | 6118 | 81141 | 0.1697 | 0.0173 | |
| GSE63941 | RPA2 | 6118 | 201756_at | 0.7581 | 0.0691 | |
| GSE77861 | RPA2 | 6118 | 201756_at | -0.1222 | 0.6497 | |
| GSE97050 | RPA2 | 6118 | A_23_P86133 | 0.0651 | 0.7898 | |
| SRP007169 | RPA2 | 6118 | RNAseq | 0.3104 | 0.4943 | |
| SRP008496 | RPA2 | 6118 | RNAseq | 0.0760 | 0.7707 | |
| SRP064894 | RPA2 | 6118 | RNAseq | 0.3252 | 0.0591 | |
| SRP133303 | RPA2 | 6118 | RNAseq | 0.4464 | 0.0057 | |
| SRP159526 | RPA2 | 6118 | RNAseq | -0.0471 | 0.8623 | |
| SRP193095 | RPA2 | 6118 | RNAseq | 0.0781 | 0.4966 | |
| SRP219564 | RPA2 | 6118 | RNAseq | 0.0819 | 0.7256 | |
| TCGA | RPA2 | 6118 | RNAseq | 0.0946 | 0.1138 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by RPA2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RPA2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RPA2 | 6118 | 0 | 6 | 24 | |
| GSE20123 | RPA2 | 6118 | 0 | 5 | 25 | |
| GSE43470 | RPA2 | 6118 | 3 | 6 | 34 | |
| GSE46452 | RPA2 | 6118 | 5 | 1 | 53 | |
| GSE47630 | RPA2 | 6118 | 8 | 3 | 29 | |
| GSE54993 | RPA2 | 6118 | 2 | 1 | 67 | |
| GSE54994 | RPA2 | 6118 | 10 | 4 | 39 | |
| GSE60625 | RPA2 | 6118 | 0 | 0 | 11 | |
| GSE74703 | RPA2 | 6118 | 2 | 4 | 30 | |
| GSE74704 | RPA2 | 6118 | 0 | 0 | 20 | |
| TCGA | RPA2 | 6118 | 11 | 23 | 62 |
Total number of gains: 41; Total number of losses: 53; Total Number of normals: 394.
Somatic mutations of RPA2:
Generating mutation plots.
Highly correlated genes for RPA2:
Showing top 20/873 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RPA2 | TFIP11 | 0.767516 | 3 | 0 | 3 |
| RPA2 | ICK | 0.753834 | 3 | 0 | 3 |
| RPA2 | SRGAP1 | 0.745715 | 3 | 0 | 3 |
| RPA2 | PRDM15 | 0.740706 | 3 | 0 | 3 |
| RPA2 | CHD4 | 0.730894 | 3 | 0 | 3 |
| RPA2 | PSMD12 | 0.726975 | 3 | 0 | 3 |
| RPA2 | DDX39A | 0.723914 | 3 | 0 | 3 |
| RPA2 | PPWD1 | 0.72143 | 3 | 0 | 3 |
| RPA2 | CISD1 | 0.720765 | 3 | 0 | 3 |
| RPA2 | HPRT1 | 0.718469 | 4 | 0 | 4 |
| RPA2 | UBA2 | 0.717684 | 3 | 0 | 3 |
| RPA2 | CHCHD6 | 0.717163 | 3 | 0 | 3 |
| RPA2 | GNPAT | 0.717129 | 3 | 0 | 3 |
| RPA2 | SP4 | 0.716935 | 3 | 0 | 3 |
| RPA2 | GMPS | 0.712965 | 4 | 0 | 4 |
| RPA2 | TATDN1 | 0.705012 | 3 | 0 | 3 |
| RPA2 | SMC6 | 0.704017 | 4 | 0 | 4 |
| RPA2 | PCNT | 0.702683 | 3 | 0 | 3 |
| RPA2 | DAZAP1 | 0.70124 | 3 | 0 | 3 |
| RPA2 | SUPT4H1 | 0.696628 | 4 | 0 | 3 |
For details and further investigation, click here
