MECOM

 

Full name: MDS1 and EVI1 complex locus Alias Symbol: MDS1-EVI1|PRDM3|KMT8E
Type: protein-coding gene Cytoband: 3q26.2
Entrez ID: 2122 HGNC ID: HGNC:3498 Ensembl Gene: ENSG00000085276 OMIM ID: 165215
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 10/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

MECOM involved pathways:

KEGG pathway Description View
hsa04010MAPK signaling pathway
hsa05200Pathways in cancer
hsa05220Chronic myeloid leukemia

 

Expression of MECOM:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 MECOM 2122 221884_at -0.3735 0.7487
GSE20347 MECOM 2122 221884_at -1.1970 0.0015
GSE23400 MECOM 2122 221884_at -0.9073 0.0000
GSE26886 MECOM 2122 226420_at -2.6665 0.0001
GSE29001 MECOM 2122 221884_at -2.0249 0.0014
GSE38129 MECOM 2122 221884_at -1.2546 0.0000
GSE45670 MECOM 2122 226420_at -0.8356 0.0446
GSE53622 MECOM 2122 105731 -1.6080 0.0000
GSE53624 MECOM 2122 105731 -1.9602 0.0000
GSE63941 MECOM 2122 221884_at 1.1812 0.4046
GSE77861 MECOM 2122 221884_at -1.3444 0.0063
GSE97050 MECOM 2122 A_23_P317324 -0.3065 0.5572
SRP007169 MECOM 2122 RNAseq -1.6517 0.0059
SRP008496 MECOM 2122 RNAseq -1.7853 0.0000
SRP064894 MECOM 2122 RNAseq -0.9353 0.0005
SRP133303 MECOM 2122 RNAseq -0.7818 0.0226
SRP159526 MECOM 2122 RNAseq -0.7445 0.0103
SRP193095 MECOM 2122 RNAseq -1.0191 0.0014
SRP219564 MECOM 2122 RNAseq -0.3297 0.6666
TCGA MECOM 2122 RNAseq -0.8185 0.0000

Upregulated datasets: 0; Downregulated datasets: 10.  

 

Survival by MECOM expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of MECOM:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 MECOM 2122 23 0 7
GSE20123 MECOM 2122 23 0 7
GSE43470 MECOM 2122 24 0 19
GSE46452 MECOM 2122 19 1 39
GSE47630 MECOM 2122 27 2 11
GSE54993 MECOM 2122 1 14 55
GSE54994 MECOM 2122 41 0 12
GSE60625 MECOM 2122 0 6 5
GSE74703 MECOM 2122 20 0 16
GSE74704 MECOM 2122 15 0 5
TCGA MECOM 2122 79 0 17

Total number of gains: 272; Total number of losses: 23; Total Number of normals: 193.  

 

Somatic mutations of MECOM:

 

Generating mutation plots.

 

Highly correlated genes for MECOM:

 

Showing top 20/1311 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
MECOMFAM3B0.773571606
MECOMMUC200.766658808
MECOMSLC10A50.734638303
MECOMRBM200.734466404
MECOMHDHD20.715719404
MECOMVSIG20.713644606
MECOMSRGAP10.71316303
MECOMCYP3A50.709914909
MECOMCTTNBP20.705694606
MECOMMACC10.705046606
MECOMCAPN140.701444505
MECOMFCHO20.698524606
MECOMHPGD0.69741612012
MECOMFMO20.69626310010
MECOMSSNA10.696124303
MECOMMBNL30.695924605
MECOMSPAG170.694778403
MECOMSH3BGRL20.694209807
MECOMFAM3D0.693955606
MECOMFAM214A0.692866605

For details and further investigation, click here