| Full name: FYVE, RhoGEF and PH domain containing 4 | Alias Symbol: FRABP|frabin|ZFYVE6|CMT4H | ||
| Type: protein-coding gene | Cytoband: 12p11.21 | ||
| Entrez ID: 121512 | HGNC ID: HGNC:19125 | Ensembl Gene: ENSG00000139132 | OMIM ID: 611104 |
| Drug and gene relationship at DGIdb | |||
Expression of FGD4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | FGD4 | 121512 | 227948_at | -0.8723 | 0.0306 | |
| GSE26886 | FGD4 | 121512 | 227948_at | -0.6649 | 0.0395 | |
| GSE45670 | FGD4 | 121512 | 227948_at | -0.8347 | 0.0003 | |
| GSE53622 | FGD4 | 121512 | 93269 | -1.3161 | 0.0000 | |
| GSE53624 | FGD4 | 121512 | 14798 | -0.9150 | 0.0000 | |
| GSE63941 | FGD4 | 121512 | 227948_at | -0.4226 | 0.4861 | |
| GSE77861 | FGD4 | 121512 | 227948_at | -0.2097 | 0.6018 | |
| GSE97050 | FGD4 | 121512 | A_33_P3404588 | -0.5763 | 0.1242 | |
| SRP007169 | FGD4 | 121512 | RNAseq | -1.0623 | 0.0123 | |
| SRP008496 | FGD4 | 121512 | RNAseq | -1.2432 | 0.0001 | |
| SRP064894 | FGD4 | 121512 | RNAseq | -1.0100 | 0.0014 | |
| SRP133303 | FGD4 | 121512 | RNAseq | -0.6108 | 0.0006 | |
| SRP159526 | FGD4 | 121512 | RNAseq | -1.0556 | 0.0030 | |
| SRP193095 | FGD4 | 121512 | RNAseq | -0.9252 | 0.0000 | |
| SRP219564 | FGD4 | 121512 | RNAseq | -0.9070 | 0.0149 | |
| TCGA | FGD4 | 121512 | RNAseq | -0.7415 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 5.
Survival by FGD4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of FGD4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | FGD4 | 121512 | 10 | 2 | 18 | |
| GSE20123 | FGD4 | 121512 | 10 | 2 | 18 | |
| GSE43470 | FGD4 | 121512 | 7 | 4 | 32 | |
| GSE46452 | FGD4 | 121512 | 10 | 1 | 48 | |
| GSE47630 | FGD4 | 121512 | 12 | 1 | 27 | |
| GSE54993 | FGD4 | 121512 | 0 | 9 | 61 | |
| GSE54994 | FGD4 | 121512 | 8 | 2 | 43 | |
| GSE60625 | FGD4 | 121512 | 0 | 1 | 10 | |
| GSE74703 | FGD4 | 121512 | 7 | 3 | 26 | |
| GSE74704 | FGD4 | 121512 | 6 | 0 | 14 | |
| TCGA | FGD4 | 121512 | 39 | 6 | 51 |
Total number of gains: 109; Total number of losses: 31; Total Number of normals: 348.
Somatic mutations of FGD4:
Generating mutation plots.
Highly correlated genes for FGD4:
Showing top 20/1079 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| FGD4 | CPT2 | 0.770556 | 3 | 0 | 3 |
| FGD4 | DCTN2 | 0.75349 | 5 | 0 | 5 |
| FGD4 | LRIG3 | 0.74578 | 3 | 0 | 3 |
| FGD4 | FAM122A | 0.732401 | 4 | 0 | 4 |
| FGD4 | MGLL | 0.732113 | 6 | 0 | 6 |
| FGD4 | RAB11A | 0.728285 | 6 | 0 | 6 |
| FGD4 | SRP14 | 0.727838 | 4 | 0 | 3 |
| FGD4 | CRADD | 0.719935 | 4 | 0 | 4 |
| FGD4 | NPY1R | 0.71956 | 3 | 0 | 3 |
| FGD4 | CHP1 | 0.718032 | 5 | 0 | 5 |
| FGD4 | APPBP2 | 0.716029 | 5 | 0 | 5 |
| FGD4 | ASPA | 0.715471 | 5 | 0 | 5 |
| FGD4 | UBQLN1 | 0.715129 | 3 | 0 | 3 |
| FGD4 | KDM3A | 0.71422 | 3 | 0 | 3 |
| FGD4 | ROR1 | 0.712838 | 5 | 0 | 4 |
| FGD4 | CA13 | 0.711417 | 3 | 0 | 3 |
| FGD4 | B3GALT4 | 0.710877 | 3 | 0 | 3 |
| FGD4 | UGP2 | 0.710194 | 4 | 0 | 3 |
| FGD4 | ZDHHC3 | 0.709888 | 5 | 0 | 4 |
| FGD4 | LGI1 | 0.709598 | 4 | 0 | 4 |
For details and further investigation, click here
