| Full name: E2F transcription factor 8 | Alias Symbol: FLJ23311 | ||
| Type: protein-coding gene | Cytoband: 11p15.1 | ||
| Entrez ID: 79733 | HGNC ID: HGNC:24727 | Ensembl Gene: ENSG00000129173 | OMIM ID: 612047 |
| Drug and gene relationship at DGIdb | |||
Expression of E2F8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | E2F8 | 79733 | 219990_at | 0.2714 | 0.8084 | |
| GSE20347 | E2F8 | 79733 | 219990_at | -0.5208 | 0.0099 | |
| GSE23400 | E2F8 | 79733 | 219990_at | 0.0447 | 0.4666 | |
| GSE26886 | E2F8 | 79733 | 219990_at | -1.1820 | 0.0032 | |
| GSE29001 | E2F8 | 79733 | 219990_at | -0.2216 | 0.6985 | |
| GSE38129 | E2F8 | 79733 | 219990_at | 0.1251 | 0.6715 | |
| GSE45670 | E2F8 | 79733 | 219990_at | 0.2813 | 0.2969 | |
| GSE53622 | E2F8 | 79733 | 5130 | -0.1867 | 0.4371 | |
| GSE53624 | E2F8 | 79733 | 5130 | -0.0944 | 0.4444 | |
| GSE63941 | E2F8 | 79733 | 219990_at | 2.8901 | 0.0014 | |
| GSE77861 | E2F8 | 79733 | 219990_at | -0.5196 | 0.1051 | |
| GSE97050 | E2F8 | 79733 | A_23_P35871 | 0.2465 | 0.3418 | |
| SRP007169 | E2F8 | 79733 | RNAseq | 0.1606 | 0.8041 | |
| SRP008496 | E2F8 | 79733 | RNAseq | -0.2251 | 0.6035 | |
| SRP064894 | E2F8 | 79733 | RNAseq | -0.2398 | 0.4949 | |
| SRP133303 | E2F8 | 79733 | RNAseq | 0.0788 | 0.8033 | |
| SRP159526 | E2F8 | 79733 | RNAseq | -0.4510 | 0.1829 | |
| SRP193095 | E2F8 | 79733 | RNAseq | -0.4733 | 0.0009 | |
| SRP219564 | E2F8 | 79733 | RNAseq | -0.1821 | 0.8307 | |
| TCGA | E2F8 | 79733 | RNAseq | 0.6332 | 0.0000 |
Upregulated datasets: 1; Downregulated datasets: 1.
Survival by E2F8 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of E2F8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | E2F8 | 79733 | 0 | 10 | 20 | |
| GSE20123 | E2F8 | 79733 | 0 | 10 | 20 | |
| GSE43470 | E2F8 | 79733 | 1 | 5 | 37 | |
| GSE46452 | E2F8 | 79733 | 7 | 5 | 47 | |
| GSE47630 | E2F8 | 79733 | 3 | 10 | 27 | |
| GSE54993 | E2F8 | 79733 | 3 | 0 | 67 | |
| GSE54994 | E2F8 | 79733 | 3 | 12 | 38 | |
| GSE60625 | E2F8 | 79733 | 0 | 0 | 11 | |
| GSE74703 | E2F8 | 79733 | 1 | 3 | 32 | |
| GSE74704 | E2F8 | 79733 | 0 | 9 | 11 | |
| TCGA | E2F8 | 79733 | 13 | 27 | 56 |
Total number of gains: 31; Total number of losses: 91; Total Number of normals: 366.
Somatic mutations of E2F8:
Generating mutation plots.
Highly correlated genes for E2F8:
Showing top 20/826 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| E2F8 | PUSL1 | 0.81842 | 3 | 0 | 3 |
| E2F8 | KIAA1522 | 0.792826 | 4 | 0 | 4 |
| E2F8 | TMEM54 | 0.778224 | 3 | 0 | 3 |
| E2F8 | CYP4X1 | 0.770823 | 3 | 0 | 3 |
| E2F8 | PPP1R8 | 0.751375 | 3 | 0 | 3 |
| E2F8 | S1PR5 | 0.750917 | 3 | 0 | 3 |
| E2F8 | ZNF543 | 0.743299 | 3 | 0 | 3 |
| E2F8 | ANKIB1 | 0.74189 | 3 | 0 | 3 |
| E2F8 | IFT80 | 0.741817 | 3 | 0 | 3 |
| E2F8 | CETN2 | 0.739476 | 3 | 0 | 3 |
| E2F8 | TFIP11 | 0.735341 | 3 | 0 | 3 |
| E2F8 | ZDHHC12 | 0.735086 | 4 | 0 | 4 |
| E2F8 | KDF1 | 0.734276 | 3 | 0 | 3 |
| E2F8 | CPVL | 0.730615 | 4 | 0 | 4 |
| E2F8 | SRGAP1 | 0.723241 | 3 | 0 | 3 |
| E2F8 | ALG10 | 0.719586 | 3 | 0 | 3 |
| E2F8 | MIS18BP1 | 0.718783 | 4 | 0 | 3 |
| E2F8 | SAMD12 | 0.718703 | 3 | 0 | 3 |
| E2F8 | RABIF | 0.717415 | 4 | 0 | 4 |
| E2F8 | SSU72 | 0.716438 | 3 | 0 | 3 |
For details and further investigation, click here
