SRMS

 

Full name: src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites Alias Symbol: SRM|dJ697K14.1|PTK70
Type: protein-coding gene Cytoband: 20q13.33
Entrez ID: 6725 HGNC ID: HGNC:11298 Ensembl Gene: ENSG00000125508 OMIM ID: 617797
Drug and gene relationship at DGIdb

 

Expression of SRMS:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 SRMS 6725 234514_at -0.2033 0.4001
GSE26886 SRMS 6725 234514_at 0.1939 0.1625
GSE45670 SRMS 6725 234514_at -0.1416 0.0874
GSE53622 SRMS 6725 7189 0.0622 0.5651
GSE53624 SRMS 6725 7189 -0.1257 0.1640
GSE63941 SRMS 6725 234514_at 0.1547 0.3091
GSE77861 SRMS 6725 234514_at -0.0664 0.6215
GSE97050 SRMS 6725 A_33_P3236798 0.3238 0.2740
SRP133303 SRMS 6725 RNAseq -0.9387 0.0329
SRP159526 SRMS 6725 RNAseq 0.6045 0.5578
TCGA SRMS 6725 RNAseq -1.0312 0.1462

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by SRMS expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of SRMS:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 SRMS 6725 14 2 14
GSE20123 SRMS 6725 14 2 14
GSE43470 SRMS 6725 11 1 31
GSE46452 SRMS 6725 35 0 24
GSE47630 SRMS 6725 25 1 14
GSE54993 SRMS 6725 0 17 53
GSE54994 SRMS 6725 29 0 24
GSE60625 SRMS 6725 0 0 11
GSE74703 SRMS 6725 10 0 26
GSE74704 SRMS 6725 11 0 9
TCGA SRMS 6725 44 4 48

Total number of gains: 193; Total number of losses: 27; Total Number of normals: 268.  

 

Somatic mutations of SRMS:

 

Generating mutation plots.

 

Highly correlated genes for SRMS:

 

Showing top 20/56 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
SRMSPOU2F20.764107303
SRMSPSKH10.704205303
SRMSLINC005290.679119303
SRMSCIITA0.670146303
SRMSFUT50.657219303
SRMSNMUR10.640881303
SRMSCCR100.640061303
SRMSRBPJL0.632591303
SRMSRNF310.611757403
SRMSC1orf1270.605713403
SRMSTAS2R450.605619403
SRMSPLXNA40.599658403
SRMSIQCJ-SCHIP1-AS10.599367303
SRMSAGXT0.596083303
SRMSSPI10.595006303
SRMSHMCN20.592864303
SRMSSGK20.592025303
SRMSARX0.589957403
SRMSGRAMD1B0.586707403
SRMSGTPBP20.582355303

For details and further investigation, click here