| Full name: Spi-1 proto-oncogene | Alias Symbol: PU.1|SPI-A|OF|SFPI1|SPI-1 | ||
| Type: protein-coding gene | Cytoband: 11p11.2 | ||
| Entrez ID: 6688 | HGNC ID: HGNC:11241 | Ensembl Gene: ENSG00000066336 | OMIM ID: 165170 |
| Drug and gene relationship at DGIdb | |||
SPI1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05200 | Pathways in cancer | |
| hsa05221 | Acute myeloid leukemia |
Expression of SPI1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SPI1 | 6688 | 205312_at | 0.2877 | 0.4897 | |
| GSE20347 | SPI1 | 6688 | 205312_at | 0.0992 | 0.2879 | |
| GSE23400 | SPI1 | 6688 | 205312_at | 0.0905 | 0.0188 | |
| GSE26886 | SPI1 | 6688 | 205312_at | 0.3132 | 0.0421 | |
| GSE29001 | SPI1 | 6688 | 205312_at | -0.1017 | 0.4245 | |
| GSE38129 | SPI1 | 6688 | 205312_at | 0.0663 | 0.5119 | |
| GSE45670 | SPI1 | 6688 | 205312_at | -0.0733 | 0.3977 | |
| GSE53622 | SPI1 | 6688 | 7223 | 0.5198 | 0.0017 | |
| GSE53624 | SPI1 | 6688 | 7223 | 0.5262 | 0.0000 | |
| GSE63941 | SPI1 | 6688 | 205312_at | 0.1867 | 0.1039 | |
| GSE77861 | SPI1 | 6688 | 205312_at | -0.1732 | 0.2721 | |
| GSE97050 | SPI1 | 6688 | A_33_P3489646 | 0.8166 | 0.0867 | |
| SRP007169 | SPI1 | 6688 | RNAseq | 2.2900 | 0.0064 | |
| SRP008496 | SPI1 | 6688 | RNAseq | 0.9147 | 0.0846 | |
| SRP064894 | SPI1 | 6688 | RNAseq | 0.9800 | 0.0002 | |
| SRP133303 | SPI1 | 6688 | RNAseq | 0.5247 | 0.0480 | |
| SRP159526 | SPI1 | 6688 | RNAseq | -0.1265 | 0.8117 | |
| SRP193095 | SPI1 | 6688 | RNAseq | 0.7295 | 0.0007 | |
| SRP219564 | SPI1 | 6688 | RNAseq | 1.4272 | 0.0067 | |
| TCGA | SPI1 | 6688 | RNAseq | 0.3925 | 0.0011 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by SPI1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SPI1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SPI1 | 6688 | 3 | 7 | 20 | |
| GSE20123 | SPI1 | 6688 | 3 | 6 | 21 | |
| GSE43470 | SPI1 | 6688 | 1 | 4 | 38 | |
| GSE46452 | SPI1 | 6688 | 8 | 5 | 46 | |
| GSE47630 | SPI1 | 6688 | 3 | 9 | 28 | |
| GSE54993 | SPI1 | 6688 | 3 | 0 | 67 | |
| GSE54994 | SPI1 | 6688 | 1 | 11 | 41 | |
| GSE60625 | SPI1 | 6688 | 0 | 0 | 11 | |
| GSE74703 | SPI1 | 6688 | 1 | 2 | 33 | |
| GSE74704 | SPI1 | 6688 | 2 | 4 | 14 | |
| TCGA | SPI1 | 6688 | 10 | 20 | 66 |
Total number of gains: 35; Total number of losses: 68; Total Number of normals: 385.
Somatic mutations of SPI1:
Generating mutation plots.
Highly correlated genes for SPI1:
Showing top 20/519 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SPI1 | C19orf38 | 0.835549 | 3 | 0 | 3 |
| SPI1 | ARHGAP9 | 0.834595 | 4 | 0 | 4 |
| SPI1 | LRRC25 | 0.80394 | 3 | 0 | 3 |
| SPI1 | CERKL | 0.796741 | 3 | 0 | 3 |
| SPI1 | SNX20 | 0.77167 | 5 | 0 | 5 |
| SPI1 | TCTN1 | 0.764339 | 3 | 0 | 3 |
| SPI1 | LY96 | 0.757384 | 4 | 0 | 3 |
| SPI1 | PARVG | 0.748452 | 6 | 0 | 5 |
| SPI1 | CCNK | 0.748427 | 3 | 0 | 3 |
| SPI1 | TMEM150B | 0.745189 | 3 | 0 | 3 |
| SPI1 | TNFRSF8 | 0.7412 | 3 | 0 | 3 |
| SPI1 | GNGT2 | 0.740762 | 5 | 0 | 5 |
| SPI1 | MED12 | 0.73915 | 3 | 0 | 3 |
| SPI1 | TMEM173 | 0.73644 | 4 | 0 | 4 |
| SPI1 | SLC2A3 | 0.733807 | 3 | 0 | 3 |
| SPI1 | DPEP2 | 0.733405 | 5 | 0 | 4 |
| SPI1 | ARPC4 | 0.731664 | 3 | 0 | 3 |
| SPI1 | KLRC3 | 0.729664 | 3 | 0 | 3 |
| SPI1 | FCGR3A | 0.727383 | 3 | 0 | 3 |
| SPI1 | KTI12 | 0.72293 | 3 | 0 | 3 |
For details and further investigation, click here
