| Full name: serum/glucocorticoid regulated kinase 2 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 20q13.12 | ||
| Entrez ID: 10110 | HGNC ID: HGNC:13900 | Ensembl Gene: ENSG00000101049 | OMIM ID: 607589 |
| Drug and gene relationship at DGIdb | |||
SGK2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04068 | FoxO signaling pathway | |
| hsa04151 | PI3K-Akt signaling pathway |
Expression of SGK2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SGK2 | 10110 | 220357_s_at | -0.0538 | 0.8352 | |
| GSE20347 | SGK2 | 10110 | 220357_s_at | -0.0344 | 0.6917 | |
| GSE23400 | SGK2 | 10110 | 220357_s_at | -0.0796 | 0.0641 | |
| GSE26886 | SGK2 | 10110 | 220357_s_at | 0.0733 | 0.6378 | |
| GSE29001 | SGK2 | 10110 | 220357_s_at | -0.1205 | 0.5082 | |
| GSE38129 | SGK2 | 10110 | 220357_s_at | -0.2360 | 0.0018 | |
| GSE45670 | SGK2 | 10110 | 220357_s_at | 0.0772 | 0.3588 | |
| GSE53622 | SGK2 | 10110 | 168068 | -0.2294 | 0.1372 | |
| GSE53624 | SGK2 | 10110 | 168068 | -0.0147 | 0.9104 | |
| GSE63941 | SGK2 | 10110 | 220357_s_at | -0.1473 | 0.4182 | |
| GSE77861 | SGK2 | 10110 | 220357_s_at | -0.0633 | 0.5770 | |
| GSE97050 | SGK2 | 10110 | A_23_P131801 | 0.1052 | 0.6326 | |
| SRP219564 | SGK2 | 10110 | RNAseq | 0.1989 | 0.7110 | |
| TCGA | SGK2 | 10110 | RNAseq | -2.4596 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by SGK2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SGK2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SGK2 | 10110 | 13 | 1 | 16 | |
| GSE20123 | SGK2 | 10110 | 13 | 1 | 16 | |
| GSE43470 | SGK2 | 10110 | 12 | 1 | 30 | |
| GSE46452 | SGK2 | 10110 | 29 | 0 | 30 | |
| GSE47630 | SGK2 | 10110 | 24 | 0 | 16 | |
| GSE54993 | SGK2 | 10110 | 0 | 17 | 53 | |
| GSE54994 | SGK2 | 10110 | 25 | 0 | 28 | |
| GSE60625 | SGK2 | 10110 | 0 | 0 | 11 | |
| GSE74703 | SGK2 | 10110 | 10 | 1 | 25 | |
| GSE74704 | SGK2 | 10110 | 9 | 0 | 11 | |
| TCGA | SGK2 | 10110 | 47 | 2 | 47 |
Total number of gains: 182; Total number of losses: 23; Total Number of normals: 283.
Somatic mutations of SGK2:
Generating mutation plots.
Highly correlated genes for SGK2:
Showing top 20/902 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SGK2 | PRODH2 | 0.721406 | 6 | 0 | 6 |
| SGK2 | FAM66D | 0.707208 | 6 | 0 | 6 |
| SGK2 | RHAG | 0.706772 | 4 | 0 | 3 |
| SGK2 | MYOG | 0.70009 | 3 | 0 | 3 |
| SGK2 | PTPRJ | 0.696065 | 3 | 0 | 3 |
| SGK2 | NOX5 | 0.69219 | 3 | 0 | 3 |
| SGK2 | RPGRIP1 | 0.690895 | 4 | 0 | 4 |
| SGK2 | CNTD2 | 0.684733 | 6 | 0 | 6 |
| SGK2 | GPR4 | 0.681972 | 4 | 0 | 4 |
| SGK2 | LUZP4 | 0.681954 | 6 | 0 | 5 |
| SGK2 | OPRK1 | 0.678245 | 3 | 0 | 3 |
| SGK2 | IFT122 | 0.677216 | 5 | 0 | 5 |
| SGK2 | UBQLN3 | 0.675346 | 4 | 0 | 4 |
| SGK2 | ADAMTS13 | 0.675208 | 4 | 0 | 4 |
| SGK2 | TAGLN3 | 0.672116 | 4 | 0 | 4 |
| SGK2 | LYPLA2 | 0.671138 | 4 | 0 | 4 |
| SGK2 | C1orf68 | 0.668475 | 3 | 0 | 3 |
| SGK2 | HPX | 0.667246 | 4 | 0 | 4 |
| SGK2 | ATF7 | 0.666754 | 3 | 0 | 3 |
| SGK2 | CPA2 | 0.665314 | 6 | 0 | 6 |
For details and further investigation, click here
