| Full name: PIF1 5'-to-3' DNA helicase | Alias Symbol: FLJ22692 | ||
| Type: protein-coding gene | Cytoband: 15q22.31 | ||
| Entrez ID: 80119 | HGNC ID: HGNC:26220 | Ensembl Gene: ENSG00000140451 | OMIM ID: 610953 |
| Drug and gene relationship at DGIdb | |||
Expression of PIF1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PIF1 | 80119 | 228252_at | 0.6299 | 0.0766 | |
| GSE26886 | PIF1 | 80119 | 228252_at | 0.6501 | 0.0710 | |
| GSE45670 | PIF1 | 80119 | 228252_at | 0.7294 | 0.0006 | |
| GSE53622 | PIF1 | 80119 | 13648 | 1.0198 | 0.0000 | |
| GSE53624 | PIF1 | 80119 | 13648 | 1.5141 | 0.0000 | |
| GSE63941 | PIF1 | 80119 | 228252_at | 0.0949 | 0.8204 | |
| GSE77861 | PIF1 | 80119 | 228252_at | 0.4274 | 0.0042 | |
| GSE97050 | PIF1 | 80119 | A_23_P416468 | 0.3575 | 0.1889 | |
| SRP007169 | PIF1 | 80119 | RNAseq | 1.7287 | 0.0166 | |
| SRP064894 | PIF1 | 80119 | RNAseq | 1.4681 | 0.0000 | |
| SRP133303 | PIF1 | 80119 | RNAseq | 1.4501 | 0.0000 | |
| SRP159526 | PIF1 | 80119 | RNAseq | 0.9636 | 0.0387 | |
| SRP193095 | PIF1 | 80119 | RNAseq | 0.9553 | 0.0000 | |
| SRP219564 | PIF1 | 80119 | RNAseq | 0.5038 | 0.1980 | |
| TCGA | PIF1 | 80119 | RNAseq | 1.0712 | 0.0000 |
Upregulated datasets: 6; Downregulated datasets: 0.
Survival by PIF1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PIF1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PIF1 | 80119 | 7 | 4 | 19 | |
| GSE20123 | PIF1 | 80119 | 7 | 4 | 19 | |
| GSE43470 | PIF1 | 80119 | 4 | 6 | 33 | |
| GSE46452 | PIF1 | 80119 | 3 | 7 | 49 | |
| GSE47630 | PIF1 | 80119 | 8 | 10 | 22 | |
| GSE54993 | PIF1 | 80119 | 5 | 6 | 59 | |
| GSE54994 | PIF1 | 80119 | 6 | 7 | 40 | |
| GSE60625 | PIF1 | 80119 | 4 | 0 | 7 | |
| GSE74703 | PIF1 | 80119 | 4 | 3 | 29 | |
| GSE74704 | PIF1 | 80119 | 3 | 4 | 13 | |
| TCGA | PIF1 | 80119 | 10 | 16 | 70 |
Total number of gains: 61; Total number of losses: 67; Total Number of normals: 360.
Somatic mutations of PIF1:
Generating mutation plots.
Highly correlated genes for PIF1:
Showing top 20/1316 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PIF1 | SRSF6 | 0.809557 | 3 | 0 | 3 |
| PIF1 | PTGS2 | 0.77643 | 3 | 0 | 3 |
| PIF1 | PLAGL2 | 0.770407 | 3 | 0 | 3 |
| PIF1 | C12orf73 | 0.770362 | 3 | 0 | 3 |
| PIF1 | EP400 | 0.76882 | 3 | 0 | 3 |
| PIF1 | DDX10 | 0.755351 | 4 | 0 | 3 |
| PIF1 | HSPBP1 | 0.753095 | 3 | 0 | 3 |
| PIF1 | MAPKAPK2 | 0.752622 | 3 | 0 | 3 |
| PIF1 | INO80E | 0.750644 | 3 | 0 | 3 |
| PIF1 | RAVER1 | 0.745718 | 4 | 0 | 3 |
| PIF1 | DPYSL2 | 0.744526 | 3 | 0 | 3 |
| PIF1 | ANKRD54 | 0.741556 | 3 | 0 | 3 |
| PIF1 | POLR1C | 0.73523 | 3 | 0 | 3 |
| PIF1 | CRTC2 | 0.735019 | 3 | 0 | 3 |
| PIF1 | SEPHS1 | 0.73211 | 4 | 0 | 4 |
| PIF1 | KIF23 | 0.728916 | 8 | 0 | 8 |
| PIF1 | CIT | 0.728313 | 3 | 0 | 3 |
| PIF1 | CDCA2 | 0.727647 | 6 | 0 | 6 |
| PIF1 | GANAB | 0.727263 | 6 | 0 | 6 |
| PIF1 | MCM7 | 0.727037 | 6 | 0 | 6 |
For details and further investigation, click here
