| Full name: 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase | Alias Symbol: PURH|AICARFT|IMPCHASE | ||
| Type: protein-coding gene | Cytoband: 2q35 | ||
| Entrez ID: 471 | HGNC ID: HGNC:794 | Ensembl Gene: ENSG00000138363 | OMIM ID: 601731 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of ATIC:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ATIC | 471 | 208758_at | 0.4294 | 0.5980 | |
| GSE20347 | ATIC | 471 | 208758_at | 0.3846 | 0.0474 | |
| GSE23400 | ATIC | 471 | 208758_at | 0.7650 | 0.0000 | |
| GSE26886 | ATIC | 471 | 208758_at | 0.5787 | 0.0026 | |
| GSE29001 | ATIC | 471 | 208758_at | 0.6682 | 0.0710 | |
| GSE38129 | ATIC | 471 | 208758_at | 0.4539 | 0.0019 | |
| GSE45670 | ATIC | 471 | 208758_at | 0.4406 | 0.0211 | |
| GSE53622 | ATIC | 471 | 39928 | 0.6726 | 0.0000 | |
| GSE53624 | ATIC | 471 | 39928 | 0.9144 | 0.0000 | |
| GSE63941 | ATIC | 471 | 208758_at | -0.0252 | 0.9522 | |
| GSE77861 | ATIC | 471 | 208758_at | 0.8631 | 0.0017 | |
| GSE97050 | ATIC | 471 | A_23_P68087 | 0.4466 | 0.2767 | |
| SRP007169 | ATIC | 471 | RNAseq | 1.3091 | 0.0023 | |
| SRP008496 | ATIC | 471 | RNAseq | 1.4401 | 0.0000 | |
| SRP064894 | ATIC | 471 | RNAseq | 0.8750 | 0.0000 | |
| SRP133303 | ATIC | 471 | RNAseq | 0.6085 | 0.0015 | |
| SRP159526 | ATIC | 471 | RNAseq | 0.8480 | 0.0025 | |
| SRP193095 | ATIC | 471 | RNAseq | 0.3762 | 0.0336 | |
| SRP219564 | ATIC | 471 | RNAseq | 0.3171 | 0.3929 | |
| TCGA | ATIC | 471 | RNAseq | 0.2168 | 0.0001 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by ATIC expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ATIC:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ATIC | 471 | 1 | 13 | 16 | |
| GSE20123 | ATIC | 471 | 1 | 13 | 16 | |
| GSE43470 | ATIC | 471 | 1 | 6 | 36 | |
| GSE46452 | ATIC | 471 | 0 | 5 | 54 | |
| GSE47630 | ATIC | 471 | 4 | 5 | 31 | |
| GSE54993 | ATIC | 471 | 0 | 3 | 67 | |
| GSE54994 | ATIC | 471 | 8 | 9 | 36 | |
| GSE60625 | ATIC | 471 | 0 | 3 | 8 | |
| GSE74703 | ATIC | 471 | 1 | 5 | 30 | |
| GSE74704 | ATIC | 471 | 1 | 7 | 12 | |
| TCGA | ATIC | 471 | 12 | 27 | 57 |
Total number of gains: 29; Total number of losses: 96; Total Number of normals: 363.
Somatic mutations of ATIC:
Generating mutation plots.
Highly correlated genes for ATIC:
Showing top 20/1949 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ATIC | DNMBP | 0.844254 | 3 | 0 | 3 |
| ATIC | DPYSL2 | 0.819258 | 3 | 0 | 3 |
| ATIC | SCNM1 | 0.780922 | 3 | 0 | 3 |
| ATIC | SRSF6 | 0.780646 | 3 | 0 | 3 |
| ATIC | PPP1CC | 0.77673 | 3 | 0 | 3 |
| ATIC | ZNF707 | 0.766142 | 3 | 0 | 3 |
| ATIC | SLC35B2 | 0.763791 | 3 | 0 | 3 |
| ATIC | POLRMT | 0.758489 | 3 | 0 | 3 |
| ATIC | SPTBN1 | 0.756967 | 3 | 0 | 3 |
| ATIC | ALS2 | 0.755222 | 4 | 0 | 4 |
| ATIC | FARS2 | 0.747777 | 3 | 0 | 3 |
| ATIC | MRPS11 | 0.746675 | 3 | 0 | 3 |
| ATIC | IRF2BPL | 0.742491 | 5 | 0 | 5 |
| ATIC | CDCA2 | 0.741059 | 4 | 0 | 4 |
| ATIC | TTL | 0.74069 | 7 | 0 | 7 |
| ATIC | PYCR2 | 0.740586 | 3 | 0 | 3 |
| ATIC | RAB34 | 0.738773 | 3 | 0 | 3 |
| ATIC | SNAP47 | 0.736085 | 3 | 0 | 3 |
| ATIC | HHEX | 0.735612 | 3 | 0 | 3 |
| ATIC | TIGD1 | 0.734305 | 4 | 0 | 4 |
For details and further investigation, click here
