| Full name: ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 | Alias Symbol: STX|ST8SIA-II|HsT19690 | ||
| Type: protein-coding gene | Cytoband: 15q26.1 | ||
| Entrez ID: 8128 | HGNC ID: HGNC:10870 | Ensembl Gene: ENSG00000140557 | OMIM ID: 602546 |
| Drug and gene relationship at DGIdb | |||
Expression of ST8SIA2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ST8SIA2 | 8128 | 221285_at | -0.0272 | 0.9518 | |
| GSE20347 | ST8SIA2 | 8128 | 221285_at | -0.0593 | 0.3810 | |
| GSE23400 | ST8SIA2 | 8128 | 221285_at | -0.1372 | 0.0000 | |
| GSE26886 | ST8SIA2 | 8128 | 221285_at | 0.2653 | 0.0240 | |
| GSE29001 | ST8SIA2 | 8128 | 221285_at | -0.2384 | 0.0551 | |
| GSE38129 | ST8SIA2 | 8128 | 221285_at | -0.1058 | 0.1264 | |
| GSE45670 | ST8SIA2 | 8128 | 221285_at | 0.1049 | 0.2287 | |
| GSE53622 | ST8SIA2 | 8128 | 49323 | 1.9124 | 0.0000 | |
| GSE53624 | ST8SIA2 | 8128 | 49323 | 1.7974 | 0.0000 | |
| GSE63941 | ST8SIA2 | 8128 | 221285_at | 0.4044 | 0.0914 | |
| GSE77861 | ST8SIA2 | 8128 | 221285_at | -0.1165 | 0.2550 | |
| GSE97050 | ST8SIA2 | 8128 | A_24_P664850 | 0.3679 | 0.3005 | |
| TCGA | ST8SIA2 | 8128 | RNAseq | 1.6022 | 0.0000 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by ST8SIA2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ST8SIA2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ST8SIA2 | 8128 | 7 | 2 | 21 | |
| GSE20123 | ST8SIA2 | 8128 | 7 | 2 | 21 | |
| GSE43470 | ST8SIA2 | 8128 | 5 | 4 | 34 | |
| GSE46452 | ST8SIA2 | 8128 | 3 | 7 | 49 | |
| GSE47630 | ST8SIA2 | 8128 | 8 | 11 | 21 | |
| GSE54993 | ST8SIA2 | 8128 | 4 | 6 | 60 | |
| GSE54994 | ST8SIA2 | 8128 | 7 | 7 | 39 | |
| GSE60625 | ST8SIA2 | 8128 | 4 | 0 | 7 | |
| GSE74703 | ST8SIA2 | 8128 | 4 | 3 | 29 | |
| GSE74704 | ST8SIA2 | 8128 | 3 | 3 | 14 | |
| TCGA | ST8SIA2 | 8128 | 18 | 12 | 66 |
Total number of gains: 70; Total number of losses: 57; Total Number of normals: 361.
Somatic mutations of ST8SIA2:
Generating mutation plots.
Highly correlated genes for ST8SIA2:
Showing top 20/709 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ST8SIA2 | MIP | 0.675788 | 4 | 0 | 3 |
| ST8SIA2 | KIAA1614 | 0.675757 | 7 | 0 | 6 |
| ST8SIA2 | ENHO | 0.67339 | 4 | 0 | 4 |
| ST8SIA2 | CCDC151 | 0.664238 | 5 | 0 | 5 |
| ST8SIA2 | CD1B | 0.662613 | 5 | 0 | 5 |
| ST8SIA2 | IL9R | 0.658736 | 5 | 0 | 5 |
| ST8SIA2 | LILRA1 | 0.65651 | 3 | 0 | 3 |
| ST8SIA2 | RBP4 | 0.655537 | 4 | 0 | 4 |
| ST8SIA2 | NEU4 | 0.655144 | 3 | 0 | 3 |
| ST8SIA2 | HOXA3 | 0.650223 | 4 | 0 | 4 |
| ST8SIA2 | DUX1 | 0.649231 | 7 | 0 | 6 |
| ST8SIA2 | SLC22A13 | 0.648555 | 6 | 0 | 5 |
| ST8SIA2 | C22orf31 | 0.647874 | 4 | 0 | 4 |
| ST8SIA2 | SALL4 | 0.647716 | 3 | 0 | 3 |
| ST8SIA2 | KCNK17 | 0.647581 | 3 | 0 | 3 |
| ST8SIA2 | P2RX6 | 0.646318 | 6 | 0 | 5 |
| ST8SIA2 | TUBB4A | 0.644435 | 5 | 0 | 5 |
| ST8SIA2 | DMRT3 | 0.643588 | 3 | 0 | 3 |
| ST8SIA2 | CBL | 0.642511 | 4 | 0 | 4 |
| ST8SIA2 | MTAP | 0.640707 | 5 | 0 | 5 |
For details and further investigation, click here
