| Full name: Cbl proto-oncogene | Alias Symbol: RNF55|c-Cbl | ||
| Type: protein-coding gene | Cytoband: 11q23.3 | ||
| Entrez ID: 867 | HGNC ID: HGNC:1541 | Ensembl Gene: ENSG00000110395 | OMIM ID: 165360 |
| Drug and gene relationship at DGIdb | |||
CBL involved pathways:
Expression of CBL:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CBL | 867 | 225231_at | 0.3711 | 0.1946 | |
| GSE20347 | CBL | 867 | 206607_at | -0.0203 | 0.8514 | |
| GSE23400 | CBL | 867 | 206607_at | -0.0916 | 0.0157 | |
| GSE26886 | CBL | 867 | 225234_at | -0.1481 | 0.4601 | |
| GSE29001 | CBL | 867 | 206607_at | -0.1744 | 0.2313 | |
| GSE38129 | CBL | 867 | 206607_at | -0.1275 | 0.1647 | |
| GSE45670 | CBL | 867 | 225231_at | 0.2438 | 0.0488 | |
| GSE53622 | CBL | 867 | 114844 | -0.0650 | 0.4418 | |
| GSE53624 | CBL | 867 | 114844 | 0.1520 | 0.0331 | |
| GSE63941 | CBL | 867 | 225231_at | -0.3607 | 0.5236 | |
| GSE77861 | CBL | 867 | 225234_at | 0.3405 | 0.0791 | |
| GSE97050 | CBL | 867 | A_33_P3256033 | -0.2102 | 0.3271 | |
| SRP007169 | CBL | 867 | RNAseq | 0.5533 | 0.1733 | |
| SRP008496 | CBL | 867 | RNAseq | 0.5880 | 0.0166 | |
| SRP064894 | CBL | 867 | RNAseq | 0.0851 | 0.7556 | |
| SRP133303 | CBL | 867 | RNAseq | 0.1021 | 0.3690 | |
| SRP159526 | CBL | 867 | RNAseq | -0.4174 | 0.0561 | |
| SRP193095 | CBL | 867 | RNAseq | 0.1058 | 0.3333 | |
| SRP219564 | CBL | 867 | RNAseq | -0.3013 | 0.3050 | |
| TCGA | CBL | 867 | RNAseq | -0.0326 | 0.5391 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by CBL expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CBL:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CBL | 867 | 1 | 11 | 18 | |
| GSE20123 | CBL | 867 | 1 | 11 | 18 | |
| GSE43470 | CBL | 867 | 2 | 8 | 33 | |
| GSE46452 | CBL | 867 | 3 | 26 | 30 | |
| GSE47630 | CBL | 867 | 2 | 19 | 19 | |
| GSE54993 | CBL | 867 | 10 | 0 | 60 | |
| GSE54994 | CBL | 867 | 5 | 19 | 29 | |
| GSE60625 | CBL | 867 | 0 | 3 | 8 | |
| GSE74703 | CBL | 867 | 1 | 5 | 30 | |
| GSE74704 | CBL | 867 | 0 | 7 | 13 | |
| TCGA | CBL | 867 | 4 | 51 | 41 |
Total number of gains: 29; Total number of losses: 160; Total Number of normals: 299.
Somatic mutations of CBL:
Generating mutation plots.
Highly correlated genes for CBL:
Showing top 20/602 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CBL | IRF2BPL | 0.843708 | 3 | 0 | 3 |
| CBL | GLI3 | 0.811636 | 3 | 0 | 3 |
| CBL | DHX33 | 0.794416 | 3 | 0 | 3 |
| CBL | NTPCR | 0.793754 | 3 | 0 | 3 |
| CBL | ATAD5 | 0.790563 | 3 | 0 | 3 |
| CBL | GML | 0.778255 | 4 | 0 | 4 |
| CBL | ADAM11 | 0.772531 | 5 | 0 | 5 |
| CBL | CCDC7 | 0.761286 | 5 | 0 | 5 |
| CBL | HHLA1 | 0.760344 | 5 | 0 | 5 |
| CBL | IL1RAPL2 | 0.759517 | 4 | 0 | 4 |
| CBL | GDF5 | 0.753472 | 5 | 0 | 5 |
| CBL | DARS2 | 0.752017 | 4 | 0 | 3 |
| CBL | RABEP2 | 0.749333 | 3 | 0 | 3 |
| CBL | THEM4 | 0.74928 | 3 | 0 | 3 |
| CBL | C6orf141 | 0.742561 | 3 | 0 | 3 |
| CBL | LMNA | 0.741886 | 4 | 0 | 4 |
| CBL | VPS37A | 0.741161 | 3 | 0 | 3 |
| CBL | DUSP18 | 0.73876 | 3 | 0 | 3 |
| CBL | SGTB | 0.738045 | 3 | 0 | 3 |
| CBL | ISG20L2 | 0.733058 | 4 | 0 | 4 |
For details and further investigation, click here
