| Full name: purinergic receptor P2X 6 | Alias Symbol: P2XM|MGC129625|P2X6 | ||
| Type: protein-coding gene | Cytoband: 22q11.21 | ||
| Entrez ID: 9127 | HGNC ID: HGNC:8538 | Ensembl Gene: ENSG00000099957 | OMIM ID: 608077 |
| Drug and gene relationship at DGIdb | |||
P2RX6 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04020 | Calcium signaling pathway |
Expression of P2RX6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | P2RX6 | 9127 | 206880_at | -0.0641 | 0.7586 | |
| GSE20347 | P2RX6 | 9127 | 206880_at | -0.1042 | 0.2992 | |
| GSE23400 | P2RX6 | 9127 | 206880_at | -0.1672 | 0.0000 | |
| GSE26886 | P2RX6 | 9127 | 206880_at | 0.0676 | 0.4565 | |
| GSE29001 | P2RX6 | 9127 | 206880_at | -0.1654 | 0.2303 | |
| GSE38129 | P2RX6 | 9127 | 206880_at | -0.1495 | 0.1137 | |
| GSE45670 | P2RX6 | 9127 | 206880_at | -0.0160 | 0.9005 | |
| GSE53622 | P2RX6 | 9127 | 89313 | -0.1660 | 0.0097 | |
| GSE53624 | P2RX6 | 9127 | 89313 | -0.2129 | 0.0733 | |
| GSE63941 | P2RX6 | 9127 | 206880_at | 0.1513 | 0.4084 | |
| GSE77861 | P2RX6 | 9127 | 206880_at | -0.1360 | 0.5238 | |
| SRP159526 | P2RX6 | 9127 | RNAseq | -0.5622 | 0.3478 | |
| SRP219564 | P2RX6 | 9127 | RNAseq | 0.0586 | 0.8947 | |
| TCGA | P2RX6 | 9127 | RNAseq | 0.6389 | 0.1145 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by P2RX6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of P2RX6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | P2RX6 | 9127 | 6 | 7 | 17 | |
| GSE20123 | P2RX6 | 9127 | 6 | 7 | 17 | |
| GSE43470 | P2RX6 | 9127 | 3 | 7 | 33 | |
| GSE46452 | P2RX6 | 9127 | 33 | 1 | 25 | |
| GSE47630 | P2RX6 | 9127 | 8 | 5 | 27 | |
| GSE54993 | P2RX6 | 9127 | 3 | 6 | 61 | |
| GSE54994 | P2RX6 | 9127 | 11 | 7 | 35 | |
| GSE60625 | P2RX6 | 9127 | 5 | 0 | 6 | |
| GSE74703 | P2RX6 | 9127 | 3 | 5 | 28 | |
| GSE74704 | P2RX6 | 9127 | 3 | 4 | 13 | |
| TCGA | P2RX6 | 9127 | 27 | 17 | 52 |
Total number of gains: 108; Total number of losses: 66; Total Number of normals: 314.
Somatic mutations of P2RX6:
Generating mutation plots.
Highly correlated genes for P2RX6:
Showing top 20/1061 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| P2RX6 | HRC | 0.789607 | 3 | 0 | 3 |
| P2RX6 | NEU3 | 0.761533 | 4 | 0 | 4 |
| P2RX6 | CCDC87 | 0.742233 | 4 | 0 | 4 |
| P2RX6 | NMNAT2 | 0.737546 | 3 | 0 | 3 |
| P2RX6 | ZNF460 | 0.734175 | 4 | 0 | 4 |
| P2RX6 | HS6ST1 | 0.731185 | 3 | 0 | 3 |
| P2RX6 | ATG10 | 0.726608 | 4 | 0 | 4 |
| P2RX6 | DAB1 | 0.726243 | 5 | 0 | 5 |
| P2RX6 | EPX | 0.724531 | 5 | 0 | 5 |
| P2RX6 | UMOD | 0.722986 | 5 | 0 | 5 |
| P2RX6 | FSTL4 | 0.719 | 4 | 0 | 4 |
| P2RX6 | CYP19A1 | 0.718532 | 5 | 0 | 5 |
| P2RX6 | RCVRN | 0.715446 | 5 | 0 | 5 |
| P2RX6 | CER1 | 0.714559 | 5 | 0 | 5 |
| P2RX6 | SST | 0.712435 | 3 | 0 | 3 |
| P2RX6 | HHLA1 | 0.710038 | 6 | 0 | 6 |
| P2RX6 | ECE2 | 0.70796 | 4 | 0 | 4 |
| P2RX6 | ADAM11 | 0.704471 | 6 | 0 | 6 |
| P2RX6 | IL17A | 0.704327 | 5 | 0 | 5 |
| P2RX6 | SAG | 0.703453 | 4 | 0 | 4 |
For details and further investigation, click here
