| Full name: sodium channel epithelial 1 gamma subunit | Alias Symbol: ENaCgamma|SCNEG | ||
| Type: protein-coding gene | Cytoband: 16p12.2 | ||
| Entrez ID: 6340 | HGNC ID: HGNC:10602 | Ensembl Gene: ENSG00000166828 | OMIM ID: 600761 |
| Drug and gene relationship at DGIdb | |||
SCNN1G involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04960 | Aldosterone-regulated sodium reabsorption |
Expression of SCNN1G:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SCNN1G | 6340 | 241436_at | -1.6335 | 0.0900 | |
| GSE20347 | SCNN1G | 6340 | 207295_at | -0.0509 | 0.5734 | |
| GSE23400 | SCNN1G | 6340 | 207295_at | -0.2279 | 0.0000 | |
| GSE26886 | SCNN1G | 6340 | 241436_at | -1.6316 | 0.0061 | |
| GSE29001 | SCNN1G | 6340 | 207295_at | -0.1633 | 0.3336 | |
| GSE38129 | SCNN1G | 6340 | 207295_at | -0.1522 | 0.0302 | |
| GSE45670 | SCNN1G | 6340 | 241436_at | -0.3069 | 0.5385 | |
| GSE63941 | SCNN1G | 6340 | 207295_at | 0.2119 | 0.1456 | |
| GSE77861 | SCNN1G | 6340 | 207295_at | -0.1407 | 0.1165 | |
| SRP007169 | SCNN1G | 6340 | RNAseq | -3.9323 | 0.0000 | |
| SRP008496 | SCNN1G | 6340 | RNAseq | -3.1406 | 0.0000 | |
| SRP064894 | SCNN1G | 6340 | RNAseq | -2.9712 | 0.0000 | |
| SRP133303 | SCNN1G | 6340 | RNAseq | -1.4500 | 0.0000 | |
| SRP159526 | SCNN1G | 6340 | RNAseq | -1.6599 | 0.0253 | |
| SRP193095 | SCNN1G | 6340 | RNAseq | -1.4526 | 0.0000 | |
| SRP219564 | SCNN1G | 6340 | RNAseq | -0.4962 | 0.6965 | |
| TCGA | SCNN1G | 6340 | RNAseq | -1.0243 | 0.0090 |
Upregulated datasets: 0; Downregulated datasets: 8.
Survival by SCNN1G expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of SCNN1G:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SCNN1G | 6340 | 6 | 4 | 20 | |
| GSE20123 | SCNN1G | 6340 | 6 | 3 | 21 | |
| GSE43470 | SCNN1G | 6340 | 3 | 3 | 37 | |
| GSE46452 | SCNN1G | 6340 | 38 | 1 | 20 | |
| GSE47630 | SCNN1G | 6340 | 11 | 6 | 23 | |
| GSE54993 | SCNN1G | 6340 | 3 | 5 | 62 | |
| GSE54994 | SCNN1G | 6340 | 4 | 10 | 39 | |
| GSE60625 | SCNN1G | 6340 | 4 | 0 | 7 | |
| GSE74703 | SCNN1G | 6340 | 3 | 2 | 31 | |
| GSE74704 | SCNN1G | 6340 | 3 | 1 | 16 | |
| TCGA | SCNN1G | 6340 | 19 | 13 | 64 |
Total number of gains: 100; Total number of losses: 48; Total Number of normals: 340.
Somatic mutations of SCNN1G:
Generating mutation plots.
Highly correlated genes for SCNN1G:
Showing top 20/1133 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SCNN1G | PHLDB1 | 0.763856 | 5 | 0 | 5 |
| SCNN1G | UMOD | 0.757601 | 4 | 0 | 4 |
| SCNN1G | PTPRN2 | 0.733583 | 4 | 0 | 4 |
| SCNN1G | SPATA18 | 0.72544 | 3 | 0 | 3 |
| SCNN1G | CPA2 | 0.718179 | 3 | 0 | 3 |
| SCNN1G | GABRA5 | 0.717407 | 3 | 0 | 3 |
| SCNN1G | RABEP2 | 0.715443 | 3 | 0 | 3 |
| SCNN1G | ART1 | 0.713649 | 5 | 0 | 5 |
| SCNN1G | ZMAT4 | 0.706141 | 4 | 0 | 4 |
| SCNN1G | EDA2R | 0.702109 | 5 | 0 | 4 |
| SCNN1G | HTR4 | 0.700564 | 5 | 0 | 5 |
| SCNN1G | ARRB1 | 0.700436 | 4 | 0 | 4 |
| SCNN1G | TTR | 0.699832 | 4 | 0 | 4 |
| SCNN1G | GJB4 | 0.699009 | 5 | 0 | 4 |
| SCNN1G | TPSG1 | 0.698249 | 5 | 0 | 5 |
| SCNN1G | KIR2DS3 | 0.697808 | 4 | 0 | 4 |
| SCNN1G | TBX6 | 0.6977 | 5 | 0 | 5 |
| SCNN1G | TCL1B | 0.696533 | 4 | 0 | 4 |
| SCNN1G | PAPPA2 | 0.695822 | 5 | 0 | 5 |
| SCNN1G | NGB | 0.695589 | 4 | 0 | 3 |
For details and further investigation, click here
