| Full name: ribosomal protein S6 kinase A6 | Alias Symbol: RSK4 | ||
| Type: protein-coding gene | Cytoband: Xq21.1 | ||
| Entrez ID: 27330 | HGNC ID: HGNC:10435 | Ensembl Gene: ENSG00000072133 | OMIM ID: 300303 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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RPS6KA6 involved pathways:
Expression of RPS6KA6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RPS6KA6 | 27330 | 228503_at | -0.2961 | 0.6600 | |
| GSE20347 | RPS6KA6 | 27330 | 220738_s_at | -0.0669 | 0.4279 | |
| GSE23400 | RPS6KA6 | 27330 | 220737_at | -0.0574 | 0.3398 | |
| GSE26886 | RPS6KA6 | 27330 | 228503_at | -0.7059 | 0.0490 | |
| GSE29001 | RPS6KA6 | 27330 | 220737_at | -0.1210 | 0.6230 | |
| GSE38129 | RPS6KA6 | 27330 | 220737_at | -0.0035 | 0.9699 | |
| GSE45670 | RPS6KA6 | 27330 | 228503_at | -0.6536 | 0.1023 | |
| GSE53622 | RPS6KA6 | 27330 | 4886 | -1.9830 | 0.0000 | |
| GSE53624 | RPS6KA6 | 27330 | 4886 | -1.8384 | 0.0000 | |
| GSE63941 | RPS6KA6 | 27330 | 228503_at | -2.6851 | 0.0103 | |
| GSE77861 | RPS6KA6 | 27330 | 220737_at | 0.0646 | 0.6575 | |
| GSE97050 | RPS6KA6 | 27330 | A_23_P125596 | -0.2241 | 0.5378 | |
| SRP064894 | RPS6KA6 | 27330 | RNAseq | -0.3894 | 0.2498 | |
| SRP133303 | RPS6KA6 | 27330 | RNAseq | -0.9036 | 0.0000 | |
| SRP193095 | RPS6KA6 | 27330 | RNAseq | -0.7079 | 0.0010 | |
| SRP219564 | RPS6KA6 | 27330 | RNAseq | -0.6204 | 0.2259 | |
| TCGA | RPS6KA6 | 27330 | RNAseq | -1.6742 | 0.0254 |
Upregulated datasets: 0; Downregulated datasets: 4.
Survival by RPS6KA6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RPS6KA6:
No record found for this gene.
Somatic mutations of RPS6KA6:
Generating mutation plots.
Highly correlated genes for RPS6KA6:
Showing top 20/469 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RPS6KA6 | RNF185-AS1 | 0.726232 | 4 | 0 | 4 |
| RPS6KA6 | OR10H3 | 0.725135 | 5 | 0 | 5 |
| RPS6KA6 | KCNJ9 | 0.722782 | 3 | 0 | 3 |
| RPS6KA6 | BPIFA1 | 0.711619 | 4 | 0 | 4 |
| RPS6KA6 | ULK4 | 0.710523 | 3 | 0 | 3 |
| RPS6KA6 | OR6A2 | 0.709824 | 4 | 0 | 4 |
| RPS6KA6 | TEX15 | 0.704134 | 4 | 0 | 4 |
| RPS6KA6 | OR2H2 | 0.700241 | 4 | 0 | 3 |
| RPS6KA6 | CD1B | 0.700087 | 5 | 0 | 5 |
| RPS6KA6 | AQP6 | 0.697229 | 4 | 0 | 4 |
| RPS6KA6 | LINC00563 | 0.695087 | 4 | 0 | 4 |
| RPS6KA6 | ATF7 | 0.690617 | 3 | 0 | 3 |
| RPS6KA6 | PTGFR | 0.689667 | 4 | 0 | 3 |
| RPS6KA6 | PSG2 | 0.686211 | 5 | 0 | 5 |
| RPS6KA6 | KRT38 | 0.682818 | 5 | 0 | 4 |
| RPS6KA6 | OPRM1 | 0.681963 | 5 | 0 | 4 |
| RPS6KA6 | CDH6 | 0.681546 | 4 | 0 | 4 |
| RPS6KA6 | TAC3 | 0.678785 | 3 | 0 | 3 |
| RPS6KA6 | GML | 0.676498 | 5 | 0 | 5 |
| RPS6KA6 | SPO11 | 0.675822 | 3 | 0 | 3 |
For details and further investigation, click here
