| Full name: adrenoceptor beta 3 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 8p11.23 | ||
| Entrez ID: 155 | HGNC ID: HGNC:288 | Ensembl Gene: ENSG00000188778 | OMIM ID: 109691 |
| Drug and gene relationship at DGIdb | |||
ADRB3 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04020 | Calcium signaling pathway | |
| hsa04022 | cGMP-PKG signaling pathway | |
| hsa04923 | Regulation of lipolysis in adipocytes | |
| hsa04924 | Renin secretion | |
| hsa04970 | Salivary secretion |
Expression of ADRB3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ADRB3 | 155 | 217303_s_at | -0.1358 | 0.5975 | |
| GSE20347 | ADRB3 | 155 | 206812_at | 0.0350 | 0.7416 | |
| GSE23400 | ADRB3 | 155 | 206812_at | -0.0559 | 0.2146 | |
| GSE26886 | ADRB3 | 155 | 206812_at | -0.0298 | 0.8453 | |
| GSE29001 | ADRB3 | 155 | 206812_at | -0.1559 | 0.5159 | |
| GSE38129 | ADRB3 | 155 | 217303_s_at | -0.1003 | 0.2573 | |
| GSE45670 | ADRB3 | 155 | 217303_s_at | 0.0908 | 0.2579 | |
| GSE63941 | ADRB3 | 155 | 217303_s_at | 0.3315 | 0.0059 | |
| GSE77861 | ADRB3 | 155 | 206812_at | -0.1314 | 0.2187 | |
| GSE97050 | ADRB3 | 155 | A_23_P168993 | -1.5076 | 0.0607 | |
| SRP133303 | ADRB3 | 155 | RNAseq | -0.2175 | 0.4374 | |
| TCGA | ADRB3 | 155 | RNAseq | -1.3324 | 0.0819 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by ADRB3 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of ADRB3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ADRB3 | 155 | 9 | 4 | 17 | |
| GSE20123 | ADRB3 | 155 | 10 | 4 | 16 | |
| GSE43470 | ADRB3 | 155 | 7 | 7 | 29 | |
| GSE46452 | ADRB3 | 155 | 23 | 4 | 32 | |
| GSE47630 | ADRB3 | 155 | 12 | 7 | 21 | |
| GSE54993 | ADRB3 | 155 | 2 | 16 | 52 | |
| GSE54994 | ADRB3 | 155 | 16 | 8 | 29 | |
| GSE60625 | ADRB3 | 155 | 3 | 0 | 8 | |
| GSE74703 | ADRB3 | 155 | 7 | 5 | 24 | |
| GSE74704 | ADRB3 | 155 | 8 | 1 | 11 | |
| TCGA | ADRB3 | 155 | 35 | 25 | 36 |
Total number of gains: 132; Total number of losses: 81; Total Number of normals: 275.
Somatic mutations of ADRB3:
Generating mutation plots.
Highly correlated genes for ADRB3:
Showing top 20/852 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ADRB3 | GFRA3 | 0.79117 | 3 | 0 | 3 |
| ADRB3 | HOXA4 | 0.780115 | 3 | 0 | 3 |
| ADRB3 | ZNF358 | 0.778195 | 3 | 0 | 3 |
| ADRB3 | ASTN1 | 0.771367 | 3 | 0 | 3 |
| ADRB3 | SMTN | 0.768693 | 3 | 0 | 3 |
| ADRB3 | ADCYAP1R1 | 0.761665 | 5 | 0 | 5 |
| ADRB3 | DMPK | 0.758279 | 3 | 0 | 3 |
| ADRB3 | C2orf16 | 0.748574 | 3 | 0 | 3 |
| ADRB3 | PTH1R | 0.747 | 3 | 0 | 3 |
| ADRB3 | SPTAN1 | 0.744103 | 3 | 0 | 3 |
| ADRB3 | ZER1 | 0.732968 | 3 | 0 | 3 |
| ADRB3 | FAM83D | 0.731801 | 3 | 0 | 3 |
| ADRB3 | CASQ1 | 0.730376 | 4 | 0 | 4 |
| ADRB3 | AKAP6 | 0.728207 | 6 | 0 | 5 |
| ADRB3 | PHYHIPL | 0.727232 | 4 | 0 | 4 |
| ADRB3 | S100B | 0.723157 | 3 | 0 | 3 |
| ADRB3 | XK | 0.719977 | 3 | 0 | 3 |
| ADRB3 | HMHB1 | 0.716507 | 3 | 0 | 3 |
| ADRB3 | TSPYL2 | 0.715388 | 4 | 0 | 3 |
| ADRB3 | LGR5 | 0.714218 | 3 | 0 | 3 |
For details and further investigation, click here
