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Severity: Warning

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Backtrace:

File: /data/webapp/var/www/html/ESCCdb/application/controllers/Result_pages.php
Line: 123
Function: exec

File: /data/webapp/var/www/html/ESCCdb/application/controllers/Result_pages.php
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Function: drawSurvPlot

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Function: require_once

Multi-Omics Database of ESCC

 

TIMM23

 

Full name: translocase of inner mitochondrial membrane 23 Alias Symbol: TIM23
Type: protein-coding gene Cytoband: 10q11.22
Entrez ID: 100287932 HGNC ID: HGNC:17312 Ensembl Gene: ENSG00000265354 OMIM ID: 605034
Drug and gene relationship at DGIdb
Screen Evidence:

 

Expression of TIMM23:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 TIMM23 100287932 224038_at -0.0883 0.6570
GSE26886 TIMM23 100287932 224038_at 0.2075 0.0345
GSE45670 TIMM23 100287932 224038_at 0.0179 0.8239
GSE53622 TIMM23 100287932 144819 0.2448 0.0000
GSE53624 TIMM23 100287932 144819 0.5438 0.0000
GSE63941 TIMM23 100287932 224038_at 0.0712 0.6276
GSE77861 TIMM23 100287932 224038_at -0.0806 0.3594
GSE97050 TIMM23 100287932 A_23_P373649 0.4566 0.1476
SRP007169 TIMM23 100287932 RNAseq 0.0570 0.8881
SRP008496 TIMM23 100287932 RNAseq 0.2189 0.4065
SRP064894 TIMM23 100287932 RNAseq 0.1874 0.2191
SRP133303 TIMM23 100287932 RNAseq 0.5349 0.0000
SRP159526 TIMM23 100287932 RNAseq -0.1238 0.7048
SRP193095 TIMM23 100287932 RNAseq -0.0860 0.4229
SRP219564 TIMM23 100287932 RNAseq 0.1488 0.6017

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by TIMM23 expression:

 

GSE53622GSE53624

 

Note: Click image to view full size file.  

Copy number change of TIMM23:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 TIMM23 100287932 2 5 23
GSE20123 TIMM23 100287932 2 5 23
GSE43470 TIMM23 100287932 2 6 35
GSE46452 TIMM23 100287932 0 13 46
GSE47630 TIMM23 100287932 4 12 24
GSE54993 TIMM23 100287932 9 0 61
GSE54994 TIMM23 100287932 2 10 41
GSE60625 TIMM23 100287932 0 0 11
GSE74703 TIMM23 100287932 2 3 31
GSE74704 TIMM23 100287932 1 4 15
TCGA TIMM23 100287932 13 22 61

Total number of gains: 37; Total number of losses: 80; Total Number of normals: 371.  

 

Somatic mutations of TIMM23:

 

Generating mutation plots.

 

Highly correlated genes for TIMM23:

 

Showing top 20/101 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
TIMM23TMEM2220.78501303
TIMM23CACNG60.763007303
TIMM23RABEP20.745731303
TIMM23ZNF4140.733319303
TIMM23GNG50.72911303
TIMM23USP130.718553303
TIMM23APOBEC3D0.717315303
TIMM23KLF140.71188403
TIMM23KLF160.708684303
TIMM23CNTD10.707838303
TIMM23MZF10.707408303
TIMM23DPP40.702716303
TIMM23IL2RA0.695808303
TIMM23PHLDB10.690502303
TIMM23MAPK120.683638404
TIMM23SLC25A420.682365303
TIMM23SDF40.673395303
TIMM23MRPL240.672562303
TIMM23ISM20.672116303
TIMM23LRTOMT0.666127303

For details and further investigation, click here