| Full name: toll like receptor 5 | Alias Symbol: TIL3|FLJ10052|MGC126430|MGC126431 | ||
| Type: protein-coding gene | Cytoband: 1q41 | ||
| Entrez ID: 7100 | HGNC ID: HGNC:11851 | Ensembl Gene: ENSG00000187554 | OMIM ID: 603031 |
| Drug and gene relationship at DGIdb | |||
TLR5 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04620 | Toll-like receptor signaling pathway | |
| hsa05132 | Salmonella infection | |
| hsa05134 | Legionellosis | |
| hsa05321 | Inflammatory bowel disease (IBD) |
Expression of TLR5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TLR5 | 7100 | 210166_at | -0.7597 | 0.1730 | |
| GSE20347 | TLR5 | 7100 | 210166_at | -0.8601 | 0.0003 | |
| GSE23400 | TLR5 | 7100 | 210166_at | -0.4020 | 0.0000 | |
| GSE26886 | TLR5 | 7100 | 210166_at | -0.8894 | 0.0346 | |
| GSE29001 | TLR5 | 7100 | 210166_at | -0.8446 | 0.0630 | |
| GSE38129 | TLR5 | 7100 | 210166_at | -0.6193 | 0.0056 | |
| GSE45670 | TLR5 | 7100 | 210166_at | -0.3867 | 0.0978 | |
| GSE53622 | TLR5 | 7100 | 55421 | -0.7283 | 0.0000 | |
| GSE53624 | TLR5 | 7100 | 55421 | -0.7007 | 0.0000 | |
| GSE63941 | TLR5 | 7100 | 210166_at | 1.1489 | 0.1301 | |
| GSE77861 | TLR5 | 7100 | 210166_at | -0.3222 | 0.1244 | |
| GSE97050 | TLR5 | 7100 | A_33_P3263423 | -0.1158 | 0.7057 | |
| SRP007169 | TLR5 | 7100 | RNAseq | -2.2512 | 0.0000 | |
| SRP008496 | TLR5 | 7100 | RNAseq | -1.9968 | 0.0000 | |
| SRP064894 | TLR5 | 7100 | RNAseq | -0.7964 | 0.0001 | |
| SRP133303 | TLR5 | 7100 | RNAseq | -1.1960 | 0.0000 | |
| SRP159526 | TLR5 | 7100 | RNAseq | -0.9607 | 0.0712 | |
| SRP193095 | TLR5 | 7100 | RNAseq | -1.0471 | 0.0000 | |
| SRP219564 | TLR5 | 7100 | RNAseq | -0.2345 | 0.6331 | |
| TCGA | TLR5 | 7100 | RNAseq | 0.0157 | 0.9142 |
Upregulated datasets: 0; Downregulated datasets: 4.
Survival by TLR5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TLR5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TLR5 | 7100 | 10 | 0 | 20 | |
| GSE20123 | TLR5 | 7100 | 10 | 0 | 20 | |
| GSE43470 | TLR5 | 7100 | 8 | 0 | 35 | |
| GSE46452 | TLR5 | 7100 | 3 | 1 | 55 | |
| GSE47630 | TLR5 | 7100 | 15 | 0 | 25 | |
| GSE54993 | TLR5 | 7100 | 0 | 6 | 64 | |
| GSE54994 | TLR5 | 7100 | 16 | 0 | 37 | |
| GSE60625 | TLR5 | 7100 | 0 | 0 | 11 | |
| GSE74703 | TLR5 | 7100 | 8 | 0 | 28 | |
| GSE74704 | TLR5 | 7100 | 4 | 0 | 16 | |
| TCGA | TLR5 | 7100 | 45 | 3 | 48 |
Total number of gains: 119; Total number of losses: 10; Total Number of normals: 359.
Somatic mutations of TLR5:
Generating mutation plots.
Highly correlated genes for TLR5:
Showing top 20/678 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TLR5 | ARPC1A | 0.739749 | 3 | 0 | 3 |
| TLR5 | APEH | 0.736236 | 3 | 0 | 3 |
| TLR5 | FBXO10 | 0.73155 | 3 | 0 | 3 |
| TLR5 | ARFGAP2 | 0.715574 | 3 | 0 | 3 |
| TLR5 | TET2 | 0.706801 | 3 | 0 | 3 |
| TLR5 | AMBRA1 | 0.703605 | 4 | 0 | 4 |
| TLR5 | ARMCX5 | 0.702065 | 3 | 0 | 3 |
| TLR5 | TBC1D22B | 0.700237 | 3 | 0 | 3 |
| TLR5 | FBXW5 | 0.696043 | 5 | 0 | 4 |
| TLR5 | ANKRD13A | 0.69214 | 3 | 0 | 3 |
| TLR5 | PPP4R1 | 0.688341 | 3 | 0 | 3 |
| TLR5 | EXD2 | 0.682915 | 3 | 0 | 3 |
| TLR5 | CAPZB | 0.678861 | 3 | 0 | 3 |
| TLR5 | AP3M1 | 0.67835 | 4 | 0 | 3 |
| TLR5 | DUSP16 | 0.676273 | 4 | 0 | 3 |
| TLR5 | MRPL27 | 0.675759 | 3 | 0 | 3 |
| TLR5 | MSRB2 | 0.672895 | 3 | 0 | 3 |
| TLR5 | COX7B | 0.669047 | 4 | 0 | 4 |
| TLR5 | PLXNB1 | 0.667879 | 4 | 0 | 4 |
| TLR5 | ANGPTL6 | 0.665619 | 3 | 0 | 3 |
For details and further investigation, click here
