| Full name: HERV-H LTR-associating 1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 8q24.22 | ||
| Entrez ID: 10086 | HGNC ID: HGNC:4904 | Ensembl Gene: ENSG00000132297 | OMIM ID: 604109 |
| Drug and gene relationship at DGIdb | |||
Expression of HHLA1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HHLA1 | 10086 | 221162_at | -0.0491 | 0.8475 | |
| GSE20347 | HHLA1 | 10086 | 221162_at | -0.0314 | 0.7732 | |
| GSE23400 | HHLA1 | 10086 | 221162_at | -0.2364 | 0.0000 | |
| GSE26886 | HHLA1 | 10086 | 221162_at | 0.0413 | 0.7618 | |
| GSE29001 | HHLA1 | 10086 | 221162_at | -0.2585 | 0.1446 | |
| GSE38129 | HHLA1 | 10086 | 221162_at | -0.1862 | 0.0435 | |
| GSE45670 | HHLA1 | 10086 | 221162_at | 0.0103 | 0.9368 | |
| GSE53622 | HHLA1 | 10086 | 56618 | -0.0019 | 0.9891 | |
| GSE53624 | HHLA1 | 10086 | 56618 | 0.1212 | 0.1268 | |
| GSE63941 | HHLA1 | 10086 | 221162_at | -0.0278 | 0.8771 | |
| GSE77861 | HHLA1 | 10086 | 233767_at | -0.0911 | 0.4509 | |
| GSE97050 | HHLA1 | A_19_P00321196 | 0.1257 | 0.5802 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by HHLA1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HHLA1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HHLA1 | 10086 | 18 | 0 | 12 | |
| GSE20123 | HHLA1 | 10086 | 18 | 1 | 11 | |
| GSE43470 | HHLA1 | 10086 | 23 | 0 | 20 | |
| GSE46452 | HHLA1 | 10086 | 27 | 0 | 32 | |
| GSE47630 | HHLA1 | 10086 | 24 | 0 | 16 | |
| GSE54993 | HHLA1 | 10086 | 0 | 24 | 46 | |
| GSE54994 | HHLA1 | 10086 | 39 | 1 | 13 | |
| GSE60625 | HHLA1 | 10086 | 0 | 7 | 4 | |
| GSE74703 | HHLA1 | 10086 | 20 | 0 | 16 | |
| GSE74704 | HHLA1 | 10086 | 12 | 0 | 8 | |
| TCGA | HHLA1 | 10086 | 67 | 2 | 27 |
Total number of gains: 248; Total number of losses: 35; Total Number of normals: 205.
Somatic mutations of HHLA1:
Generating mutation plots.
Highly correlated genes for HHLA1:
Showing top 20/1125 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HHLA1 | CGA | 0.785765 | 4 | 0 | 4 |
| HHLA1 | MKS1 | 0.783111 | 3 | 0 | 3 |
| HHLA1 | RABEP2 | 0.771274 | 4 | 0 | 4 |
| HHLA1 | MAPK11 | 0.767828 | 3 | 0 | 3 |
| HHLA1 | CBL | 0.760344 | 5 | 0 | 5 |
| HHLA1 | CA5B | 0.758935 | 5 | 0 | 5 |
| HHLA1 | TBC1D9B | 0.758585 | 3 | 0 | 3 |
| HHLA1 | SLC4A4 | 0.747592 | 5 | 0 | 5 |
| HHLA1 | CD33 | 0.747563 | 5 | 0 | 5 |
| HHLA1 | ITGB3 | 0.744325 | 5 | 0 | 4 |
| HHLA1 | EDA2R | 0.743911 | 6 | 0 | 5 |
| HHLA1 | MCC | 0.743554 | 3 | 0 | 3 |
| HHLA1 | TCP10L | 0.737766 | 4 | 0 | 4 |
| HHLA1 | GALNT8 | 0.736302 | 4 | 0 | 4 |
| HHLA1 | DOCK5 | 0.736056 | 3 | 0 | 3 |
| HHLA1 | CRHR2 | 0.733231 | 4 | 0 | 4 |
| HHLA1 | E2F4 | 0.731672 | 8 | 0 | 7 |
| HHLA1 | DISC1 | 0.730022 | 5 | 0 | 5 |
| HHLA1 | C11orf68 | 0.729341 | 3 | 0 | 3 |
| HHLA1 | PSG5 | 0.729044 | 6 | 0 | 6 |
For details and further investigation, click here
