| Full name: TNF receptor superfamily member 10a | Alias Symbol: DR4|Apo2|TRAILR-1|CD261|TRAILR1 | ||
| Type: protein-coding gene | Cytoband: 8p21.3 | ||
| Entrez ID: 8797 | HGNC ID: HGNC:11904 | Ensembl Gene: ENSG00000104689 | OMIM ID: 603611 |
| Drug and gene relationship at DGIdb | |||
TNFRSF10A involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04210 | Apoptosis | |
| hsa04650 | Natural killer cell mediated cytotoxicity | |
| hsa05162 | Measles |
Expression of TNFRSF10A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TNFRSF10A | 8797 | 231775_at | 0.8178 | 0.2492 | |
| GSE26886 | TNFRSF10A | 8797 | 231775_at | 0.1391 | 0.6534 | |
| GSE45670 | TNFRSF10A | 8797 | 231775_at | 0.2617 | 0.2545 | |
| GSE63941 | TNFRSF10A | 8797 | 231775_at | 0.5496 | 0.6297 | |
| GSE77861 | TNFRSF10A | 8797 | 241371_at | 0.2977 | 0.1841 | |
| GSE97050 | TNFRSF10A | 8797 | A_23_P255653 | 0.8127 | 0.2253 | |
| SRP007169 | TNFRSF10A | 8797 | RNAseq | 0.8590 | 0.0847 | |
| SRP008496 | TNFRSF10A | 8797 | RNAseq | 0.4504 | 0.1344 | |
| SRP064894 | TNFRSF10A | 8797 | RNAseq | 0.0418 | 0.8768 | |
| SRP133303 | TNFRSF10A | 8797 | RNAseq | -0.0998 | 0.7257 | |
| SRP159526 | TNFRSF10A | 8797 | RNAseq | -0.3264 | 0.3720 | |
| SRP193095 | TNFRSF10A | 8797 | RNAseq | 0.1201 | 0.4031 | |
| SRP219564 | TNFRSF10A | 8797 | RNAseq | 0.0904 | 0.8731 | |
| TCGA | TNFRSF10A | 8797 | RNAseq | 0.3694 | 0.0016 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by TNFRSF10A expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of TNFRSF10A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TNFRSF10A | 8797 | 4 | 12 | 14 | |
| GSE20123 | TNFRSF10A | 8797 | 4 | 12 | 14 | |
| GSE43470 | TNFRSF10A | 8797 | 4 | 9 | 30 | |
| GSE46452 | TNFRSF10A | 8797 | 13 | 13 | 33 | |
| GSE47630 | TNFRSF10A | 8797 | 10 | 8 | 22 | |
| GSE54993 | TNFRSF10A | 8797 | 2 | 14 | 54 | |
| GSE54994 | TNFRSF10A | 8797 | 8 | 18 | 27 | |
| GSE60625 | TNFRSF10A | 8797 | 3 | 0 | 8 | |
| GSE74703 | TNFRSF10A | 8797 | 4 | 7 | 25 | |
| GSE74704 | TNFRSF10A | 8797 | 3 | 8 | 9 | |
| TCGA | TNFRSF10A | 8797 | 14 | 43 | 39 |
Total number of gains: 69; Total number of losses: 144; Total Number of normals: 275.
Somatic mutations of TNFRSF10A:
Generating mutation plots.
Highly correlated genes for TNFRSF10A:
Showing top 20/82 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TNFRSF10A | CXorf21 | 0.775732 | 3 | 0 | 3 |
| TNFRSF10A | PABPC1L | 0.772392 | 3 | 0 | 3 |
| TNFRSF10A | GTF2H3 | 0.734335 | 3 | 0 | 3 |
| TNFRSF10A | MYO10 | 0.726854 | 3 | 0 | 3 |
| TNFRSF10A | NSUN6 | 0.723987 | 3 | 0 | 3 |
| TNFRSF10A | TMEM241 | 0.696175 | 3 | 0 | 3 |
| TNFRSF10A | C9orf64 | 0.681358 | 3 | 0 | 3 |
| TNFRSF10A | ZNF611 | 0.671986 | 3 | 0 | 3 |
| TNFRSF10A | TCF7 | 0.662485 | 4 | 0 | 3 |
| TNFRSF10A | PDP1 | 0.66072 | 3 | 0 | 3 |
| TNFRSF10A | ZNF160 | 0.658607 | 3 | 0 | 3 |
| TNFRSF10A | FBXW12 | 0.657744 | 3 | 0 | 3 |
| TNFRSF10A | TNFRSF10B | 0.654706 | 5 | 0 | 4 |
| TNFRSF10A | TAF1A | 0.649682 | 4 | 0 | 3 |
| TNFRSF10A | PODNL1 | 0.649325 | 3 | 0 | 3 |
| TNFRSF10A | SSBP3-AS1 | 0.646371 | 3 | 0 | 3 |
| TNFRSF10A | MCM4 | 0.642075 | 4 | 0 | 3 |
| TNFRSF10A | TGS1 | 0.628291 | 3 | 0 | 3 |
| TNFRSF10A | FAM91A1 | 0.62365 | 4 | 0 | 3 |
| TNFRSF10A | NAA25 | 0.620981 | 3 | 0 | 3 |
For details and further investigation, click here
