TCF7

 

Full name: transcription factor 7 Alias Symbol: TCF-1
Type: protein-coding gene Cytoband: 5q31.1
Entrez ID: 6932 HGNC ID: HGNC:11639 Ensembl Gene: ENSG00000081059 OMIM ID: 189908
Drug and gene relationship at DGIdb

 

TCF7 involved pathways:

KEGG pathway Description View
hsa04310Wnt signaling pathway
hsa04390Hippo signaling pathway
hsa04520Adherens junction
hsa04916Melanogenesis
hsa05200Pathways in cancer
hsa05210Colorectal cancer
hsa05213Endometrial cancer
hsa05215Prostate cancer
hsa05216Thyroid cancer
hsa05217Basal cell carcinoma
hsa05221Acute myeloid leukemia

 

Expression of TCF7:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 TCF7 6932 205255_x_at 0.1549 0.7289
GSE20347 TCF7 6932 205255_x_at 0.4346 0.0056
GSE23400 TCF7 6932 205255_x_at 0.0792 0.0827
GSE26886 TCF7 6932 205255_x_at 0.6015 0.0022
GSE29001 TCF7 6932 205255_x_at 0.4030 0.0194
GSE38129 TCF7 6932 205255_x_at 0.2272 0.1929
GSE45670 TCF7 6932 205255_x_at 0.2256 0.1353
GSE53622 TCF7 6932 40017 0.1929 0.2154
GSE53624 TCF7 6932 40017 0.1464 0.2333
GSE63941 TCF7 6932 205255_x_at -0.1452 0.6077
GSE77861 TCF7 6932 205255_x_at 0.1921 0.5826
GSE97050 TCF7 6932 A_33_P3250671 0.5041 0.4189
SRP007169 TCF7 6932 RNAseq 1.2978 0.1697
SRP064894 TCF7 6932 RNAseq 0.6885 0.0116
SRP133303 TCF7 6932 RNAseq -0.2004 0.4157
SRP159526 TCF7 6932 RNAseq -0.5083 0.3209
SRP193095 TCF7 6932 RNAseq 0.3145 0.1499
SRP219564 TCF7 6932 RNAseq 0.4193 0.4672
TCGA TCF7 6932 RNAseq 0.0412 0.7510

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by TCF7 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of TCF7:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 TCF7 6932 2 11 17
GSE20123 TCF7 6932 3 11 16
GSE43470 TCF7 6932 2 8 33
GSE46452 TCF7 6932 0 27 32
GSE47630 TCF7 6932 0 21 19
GSE54993 TCF7 6932 9 1 60
GSE54994 TCF7 6932 2 14 37
GSE60625 TCF7 6932 0 0 11
GSE74703 TCF7 6932 2 5 29
GSE74704 TCF7 6932 2 5 13
TCGA TCF7 6932 3 37 56

Total number of gains: 25; Total number of losses: 140; Total Number of normals: 323.  

 

Somatic mutations of TCF7:

 

Generating mutation plots.

 

Highly correlated genes for TCF7:

 

Showing top 20/197 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
TCF7ARID3A0.732966303
TCF7FERMT30.723511303
TCF7CCDC1520.712058505
TCF7FBXW120.706044808
TCF7NLN0.704731404
TCF7UACA0.702561303
TCF7CMBL0.69692404
TCF7NOC4L0.696766403
TCF7WDPCP0.684456505
TCF7PRR110.6825831008
TCF7TSPAN130.6794303
TCF7TNRC6C-AS10.67679404
TCF7GINS20.673297303
TCF7CHPF20.667648303
TCF7TNFRSF10A0.662485403
TCF7SFTPB0.65209505
TCF7RIN10.652011403
TCF7SLC22A30.648195403
TCF7HOXB90.647356404
TCF7PECR0.647092505

For details and further investigation, click here