MCM4

 

Full name: minichromosome maintenance complex component 4 Alias Symbol: CDC54|hCdc21|P1-Cdc21|MGC33310
Type: protein-coding gene Cytoband: 8q11.21
Entrez ID: 4173 HGNC ID: HGNC:6947 Ensembl Gene: ENSG00000104738 OMIM ID: 602638
Drug and gene relationship at DGIdb
Screen Evidence:

 

MCM4 involved pathways:

KEGG pathway Description View
hsa04110Cell cycle

 

Expression of MCM4:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 MCM4 4173 212141_at 1.1527 0.0877
GSE20347 MCM4 4173 222036_s_at 1.1780 0.0000
GSE23400 MCM4 4173 222036_s_at 1.4758 0.0000
GSE26886 MCM4 4173 222036_s_at 0.9834 0.0000
GSE29001 MCM4 4173 222036_s_at 1.1652 0.0000
GSE38129 MCM4 4173 222036_s_at 1.4214 0.0000
GSE45670 MCM4 4173 212141_at 1.0853 0.0000
GSE53622 MCM4 4173 66334 1.4851 0.0000
GSE53624 MCM4 4173 126031 1.4889 0.0000
GSE63941 MCM4 4173 212141_at 2.0218 0.0010
GSE77861 MCM4 4173 222036_s_at 0.6964 0.0525
GSE97050 MCM4 4173 A_23_P370989 1.7508 0.1163
SRP007169 MCM4 4173 RNAseq 1.2883 0.0004
SRP008496 MCM4 4173 RNAseq 1.0957 0.0000
SRP064894 MCM4 4173 RNAseq 1.5707 0.0000
SRP133303 MCM4 4173 RNAseq 0.9544 0.0000
SRP159526 MCM4 4173 RNAseq 1.2266 0.0000
SRP193095 MCM4 4173 RNAseq 0.8589 0.0000
SRP219564 MCM4 4173 RNAseq 1.6112 0.0066
TCGA MCM4 4173 RNAseq 0.6887 0.0000

Upregulated datasets: 13; Downregulated datasets: 0.  

 

Survival by MCM4 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of MCM4:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 MCM4 4173 16 1 13
GSE20123 MCM4 4173 16 1 13
GSE43470 MCM4 4173 14 3 26
GSE46452 MCM4 4173 21 3 35
GSE47630 MCM4 4173 21 2 17
GSE54993 MCM4 4173 1 16 53
GSE54994 MCM4 4173 27 0 26
GSE60625 MCM4 4173 0 5 6
GSE74703 MCM4 4173 12 2 22
GSE74704 MCM4 4173 12 0 8
TCGA MCM4 4173 47 5 44

Total number of gains: 187; Total number of losses: 38; Total Number of normals: 263.  

 

Somatic mutations of MCM4:

 

Generating mutation plots.

 

Highly correlated genes for MCM4:

 

Showing top 20/1893 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
MCM4CENPF0.84647212012
MCM4TRIP130.82390713013
MCM4UBE2C0.82118513013
MCM4PRKDC0.8199812012
MCM4GINS10.81588612012
MCM4CEP550.81366512011
MCM4TOP2A0.80175313012
MCM4PNPT10.800562606
MCM4MYBL20.80023712012
MCM4CDK10.79738812011
MCM4AURKA0.79472813013
MCM4KIF140.79413813012
MCM4TACC30.79368312012
MCM4NEK20.79274613012
MCM4CDKN30.79136813013
MCM4AURKB0.79064213012
MCM4TPX20.78987613013
MCM4KNSTRN0.787776707
MCM4KIF2C0.78720513012
MCM4MELK0.78681712011

For details and further investigation, click here