| Full name: pyruvate dehyrogenase phosphatase catalytic subunit 1 | Alias Symbol: PDP|PDH|PPM2A | ||
| Type: protein-coding gene | Cytoband: 8q22.1 | ||
| Entrez ID: 54704 | HGNC ID: HGNC:9279 | Ensembl Gene: ENSG00000164951 | OMIM ID: 605993 |
| Drug and gene relationship at DGIdb | |||
Expression of PDP1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PDP1 | 54704 | 222572_at | 1.0583 | 0.0400 | |
| GSE20347 | PDP1 | 54704 | 218273_s_at | 0.5275 | 0.0536 | |
| GSE23400 | PDP1 | 54704 | 218273_s_at | 0.2957 | 0.0001 | |
| GSE26886 | PDP1 | 54704 | 222572_at | -0.1473 | 0.7570 | |
| GSE29001 | PDP1 | 54704 | 218273_s_at | 0.3758 | 0.4166 | |
| GSE38129 | PDP1 | 54704 | 218273_s_at | 0.5639 | 0.0931 | |
| GSE45670 | PDP1 | 54704 | 222572_at | 0.9277 | 0.0001 | |
| GSE53622 | PDP1 | 54704 | 117049 | 0.4966 | 0.0000 | |
| GSE53624 | PDP1 | 54704 | 117049 | 0.5940 | 0.0000 | |
| GSE63941 | PDP1 | 54704 | 222572_at | 0.7653 | 0.3213 | |
| GSE77861 | PDP1 | 54704 | 222572_at | 1.1054 | 0.0536 | |
| GSE97050 | PDP1 | 54704 | A_33_P3369761 | 0.6177 | 0.1189 | |
| SRP007169 | PDP1 | 54704 | RNAseq | 0.3549 | 0.4038 | |
| SRP008496 | PDP1 | 54704 | RNAseq | 0.5034 | 0.0932 | |
| SRP064894 | PDP1 | 54704 | RNAseq | 1.0529 | 0.0008 | |
| SRP133303 | PDP1 | 54704 | RNAseq | 0.8536 | 0.0000 | |
| SRP159526 | PDP1 | 54704 | RNAseq | 0.3073 | 0.5644 | |
| SRP193095 | PDP1 | 54704 | RNAseq | 0.4816 | 0.0184 | |
| SRP219564 | PDP1 | 54704 | RNAseq | 0.0404 | 0.9235 | |
| TCGA | PDP1 | 54704 | RNAseq | 0.2736 | 0.0005 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by PDP1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PDP1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PDP1 | 54704 | 16 | 1 | 13 | |
| GSE20123 | PDP1 | 54704 | 17 | 1 | 12 | |
| GSE43470 | PDP1 | 54704 | 21 | 1 | 21 | |
| GSE46452 | PDP1 | 54704 | 22 | 0 | 37 | |
| GSE47630 | PDP1 | 54704 | 24 | 0 | 16 | |
| GSE54993 | PDP1 | 54704 | 0 | 20 | 50 | |
| GSE54994 | PDP1 | 54704 | 34 | 1 | 18 | |
| GSE60625 | PDP1 | 54704 | 0 | 4 | 7 | |
| GSE74703 | PDP1 | 54704 | 18 | 1 | 17 | |
| GSE74704 | PDP1 | 54704 | 12 | 0 | 8 | |
| TCGA | PDP1 | 54704 | 56 | 1 | 39 |
Total number of gains: 220; Total number of losses: 30; Total Number of normals: 238.
Somatic mutations of PDP1:
Generating mutation plots.
Highly correlated genes for PDP1:
Showing top 20/1240 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PDP1 | SLC39A10 | 0.832169 | 3 | 0 | 3 |
| PDP1 | CDCA2 | 0.811833 | 4 | 0 | 4 |
| PDP1 | STX16 | 0.807324 | 3 | 0 | 3 |
| PDP1 | EIF1AD | 0.760776 | 3 | 0 | 3 |
| PDP1 | DGUOK | 0.7544 | 3 | 0 | 3 |
| PDP1 | ANLN | 0.742678 | 5 | 0 | 5 |
| PDP1 | C8orf76 | 0.742314 | 5 | 0 | 5 |
| PDP1 | MTRR | 0.738557 | 3 | 0 | 3 |
| PDP1 | POMZP3 | 0.719106 | 3 | 0 | 3 |
| PDP1 | ASXL1 | 0.717062 | 3 | 0 | 3 |
| PDP1 | PET117 | 0.711235 | 3 | 0 | 3 |
| PDP1 | EME1 | 0.71053 | 4 | 0 | 4 |
| PDP1 | LEMD1 | 0.709359 | 3 | 0 | 3 |
| PDP1 | CLDN12 | 0.707208 | 4 | 0 | 3 |
| PDP1 | CKAP2L | 0.706892 | 5 | 0 | 5 |
| PDP1 | LRP8 | 0.701844 | 6 | 0 | 6 |
| PDP1 | DHX37 | 0.700395 | 4 | 0 | 4 |
| PDP1 | AGTRAP | 0.698353 | 4 | 0 | 4 |
| PDP1 | MAP4K4 | 0.695649 | 3 | 0 | 3 |
| PDP1 | SLC7A6OS | 0.695021 | 4 | 0 | 4 |
For details and further investigation, click here
