| Full name: trimethylguanosine synthase 1 | Alias Symbol: PIMT | ||
| Type: protein-coding gene | Cytoband: 8q12.1 | ||
| Entrez ID: 96764 | HGNC ID: HGNC:17843 | Ensembl Gene: ENSG00000137574 | OMIM ID: 606461 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of TGS1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TGS1 | 96764 | 219231_at | 1.0092 | 0.0255 | |
| GSE20347 | TGS1 | 96764 | 219231_at | 1.1057 | 0.0000 | |
| GSE23400 | TGS1 | 96764 | 219231_at | 0.7631 | 0.0000 | |
| GSE26886 | TGS1 | 96764 | 219231_at | 0.8998 | 0.0000 | |
| GSE29001 | TGS1 | 96764 | 219231_at | 0.6588 | 0.0023 | |
| GSE38129 | TGS1 | 96764 | 219231_at | 0.9938 | 0.0000 | |
| GSE45670 | TGS1 | 96764 | 238346_s_at | 0.6983 | 0.0001 | |
| GSE53622 | TGS1 | 96764 | 110120 | 0.4221 | 0.0000 | |
| GSE53624 | TGS1 | 96764 | 110120 | 0.6863 | 0.0000 | |
| GSE63941 | TGS1 | 96764 | 219231_at | 0.7187 | 0.0941 | |
| GSE77861 | TGS1 | 96764 | 238346_s_at | 0.6933 | 0.0553 | |
| GSE97050 | TGS1 | 96764 | A_33_P3337771 | 0.2273 | 0.3568 | |
| SRP007169 | TGS1 | 96764 | RNAseq | 0.9731 | 0.0052 | |
| SRP008496 | TGS1 | 96764 | RNAseq | 1.0189 | 0.0000 | |
| SRP064894 | TGS1 | 96764 | RNAseq | 0.5004 | 0.0242 | |
| SRP133303 | TGS1 | 96764 | RNAseq | 0.4689 | 0.0053 | |
| SRP159526 | TGS1 | 96764 | RNAseq | 0.7453 | 0.0001 | |
| SRP193095 | TGS1 | 96764 | RNAseq | 0.5908 | 0.0000 | |
| SRP219564 | TGS1 | 96764 | RNAseq | 0.4217 | 0.2771 | |
| TCGA | TGS1 | 96764 | RNAseq | 0.1980 | 0.0003 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by TGS1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TGS1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TGS1 | 96764 | 14 | 1 | 15 | |
| GSE20123 | TGS1 | 96764 | 14 | 1 | 15 | |
| GSE43470 | TGS1 | 96764 | 13 | 3 | 27 | |
| GSE46452 | TGS1 | 96764 | 20 | 3 | 36 | |
| GSE47630 | TGS1 | 96764 | 23 | 1 | 16 | |
| GSE54993 | TGS1 | 96764 | 1 | 16 | 53 | |
| GSE54994 | TGS1 | 96764 | 28 | 0 | 25 | |
| GSE60625 | TGS1 | 96764 | 0 | 4 | 7 | |
| GSE74703 | TGS1 | 96764 | 12 | 2 | 22 | |
| GSE74704 | TGS1 | 96764 | 10 | 0 | 10 | |
| TCGA | TGS1 | 96764 | 43 | 8 | 45 |
Total number of gains: 178; Total number of losses: 39; Total Number of normals: 271.
Somatic mutations of TGS1:
Generating mutation plots.
Highly correlated genes for TGS1:
Showing top 20/1756 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TGS1 | MTERF3 | 0.797014 | 9 | 0 | 9 |
| TGS1 | RRS1 | 0.772771 | 10 | 0 | 10 |
| TGS1 | RBM12B | 0.744552 | 6 | 0 | 6 |
| TGS1 | PRKDC | 0.741463 | 11 | 0 | 11 |
| TGS1 | POLR2K | 0.735067 | 8 | 0 | 8 |
| TGS1 | SLC39A3 | 0.734589 | 4 | 0 | 4 |
| TGS1 | STK3 | 0.728889 | 10 | 0 | 10 |
| TGS1 | RICTOR | 0.728127 | 4 | 0 | 4 |
| TGS1 | PTDSS1 | 0.724612 | 11 | 0 | 10 |
| TGS1 | TCF3 | 0.721148 | 11 | 0 | 10 |
| TGS1 | CCT5 | 0.721137 | 9 | 0 | 8 |
| TGS1 | UCK2 | 0.718937 | 3 | 0 | 3 |
| TGS1 | NAF1 | 0.716355 | 4 | 0 | 4 |
| TGS1 | TP53I13 | 0.711796 | 4 | 0 | 3 |
| TGS1 | MTBP | 0.711194 | 5 | 0 | 4 |
| TGS1 | SLC7A6OS | 0.709983 | 4 | 0 | 4 |
| TGS1 | ATAD2 | 0.707742 | 11 | 0 | 11 |
| TGS1 | STMN1 | 0.707557 | 10 | 0 | 10 |
| TGS1 | DSCC1 | 0.707377 | 9 | 0 | 8 |
| TGS1 | LAPTM4B | 0.707218 | 12 | 0 | 10 |
For details and further investigation, click here
