| Full name: cholinergic receptor nicotinic alpha 4 subunit | Alias Symbol: BFNC | ||
| Type: protein-coding gene | Cytoband: 20q13.33 | ||
| Entrez ID: 1137 | HGNC ID: HGNC:1958 | Ensembl Gene: ENSG00000101204 | OMIM ID: 118504 |
| Drug and gene relationship at DGIdb | |||
CHRNA4 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04725 | Cholinergic synapse |
Expression of CHRNA4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CHRNA4 | 1137 | 206735_at | -0.0614 | 0.7433 | |
| GSE20347 | CHRNA4 | 1137 | 206735_at | 0.0037 | 0.9746 | |
| GSE23400 | CHRNA4 | 1137 | 206735_at | -0.1545 | 0.0000 | |
| GSE26886 | CHRNA4 | 1137 | 206735_at | 0.0855 | 0.6400 | |
| GSE29001 | CHRNA4 | 1137 | 206735_at | -0.0577 | 0.7609 | |
| GSE38129 | CHRNA4 | 1137 | 206735_at | -0.1327 | 0.0625 | |
| GSE45670 | CHRNA4 | 1137 | 206735_at | -0.0242 | 0.8789 | |
| GSE53622 | CHRNA4 | 1137 | 25745 | 0.2124 | 0.0193 | |
| GSE53624 | CHRNA4 | 1137 | 25745 | 0.1516 | 0.0722 | |
| GSE63941 | CHRNA4 | 1137 | 206735_at | -0.2144 | 0.2819 | |
| GSE77861 | CHRNA4 | 1137 | 206735_at | -0.1259 | 0.4783 | |
| GSE97050 | CHRNA4 | 1137 | A_33_P3217584 | -0.1765 | 0.7054 | |
| TCGA | CHRNA4 | 1137 | RNAseq | -0.4349 | 0.6211 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by CHRNA4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CHRNA4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CHRNA4 | 1137 | 14 | 2 | 14 | |
| GSE20123 | CHRNA4 | 1137 | 14 | 2 | 14 | |
| GSE43470 | CHRNA4 | 1137 | 11 | 1 | 31 | |
| GSE46452 | CHRNA4 | 1137 | 35 | 0 | 24 | |
| GSE47630 | CHRNA4 | 1137 | 25 | 1 | 14 | |
| GSE54993 | CHRNA4 | 1137 | 0 | 17 | 53 | |
| GSE54994 | CHRNA4 | 1137 | 29 | 0 | 24 | |
| GSE60625 | CHRNA4 | 1137 | 0 | 0 | 11 | |
| GSE74703 | CHRNA4 | 1137 | 10 | 0 | 26 | |
| GSE74704 | CHRNA4 | 1137 | 11 | 0 | 9 | |
| TCGA | CHRNA4 | 1137 | 44 | 4 | 48 |
Total number of gains: 193; Total number of losses: 27; Total Number of normals: 268.
Somatic mutations of CHRNA4:
Generating mutation plots.
Highly correlated genes for CHRNA4:
Showing top 20/500 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CHRNA4 | DGCR10 | 0.718382 | 3 | 0 | 3 |
| CHRNA4 | IGFN1 | 0.696881 | 3 | 0 | 3 |
| CHRNA4 | ISYNA1 | 0.678971 | 4 | 0 | 3 |
| CHRNA4 | PNMT | 0.66961 | 6 | 0 | 5 |
| CHRNA4 | PYDC1 | 0.663946 | 4 | 0 | 3 |
| CHRNA4 | GPR26 | 0.660598 | 4 | 0 | 4 |
| CHRNA4 | FAM170A | 0.657721 | 3 | 0 | 3 |
| CHRNA4 | OR2F2 | 0.648989 | 5 | 0 | 3 |
| CHRNA4 | IL26 | 0.648484 | 3 | 0 | 3 |
| CHRNA4 | LCN1 | 0.647177 | 3 | 0 | 3 |
| CHRNA4 | KCNQ2 | 0.646523 | 5 | 0 | 5 |
| CHRNA4 | CECR9 | 0.646385 | 4 | 0 | 4 |
| CHRNA4 | NOS2 | 0.645043 | 3 | 0 | 3 |
| CHRNA4 | HNF1A | 0.639585 | 8 | 0 | 8 |
| CHRNA4 | CASR | 0.639016 | 5 | 0 | 3 |
| CHRNA4 | ANKFN1 | 0.638831 | 4 | 0 | 3 |
| CHRNA4 | C2CD4C | 0.638773 | 3 | 0 | 3 |
| CHRNA4 | BSND | 0.637435 | 4 | 0 | 3 |
| CHRNA4 | ZNF483 | 0.636855 | 4 | 0 | 4 |
| CHRNA4 | TECTA | 0.634263 | 5 | 0 | 3 |
For details and further investigation, click here
