| Full name: target of EGR1, exonuclease | Alias Symbol: hCaf1z | ||
| Type: protein-coding gene | Cytoband: 1p34.1 | ||
| Entrez ID: 114034 | HGNC ID: HGNC:15954 | Ensembl Gene: ENSG00000132773 | OMIM ID: 613931 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of TOE1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TOE1 | 114034 | 204080_at | 0.2883 | 0.5548 | |
| GSE20347 | TOE1 | 114034 | 204080_at | 0.1155 | 0.3038 | |
| GSE23400 | TOE1 | 114034 | 204080_at | -0.0081 | 0.8657 | |
| GSE26886 | TOE1 | 114034 | 204080_at | 0.4719 | 0.0007 | |
| GSE29001 | TOE1 | 114034 | 204080_at | 0.0389 | 0.8417 | |
| GSE38129 | TOE1 | 114034 | 204080_at | 0.0294 | 0.7435 | |
| GSE45670 | TOE1 | 114034 | 204080_at | 0.1369 | 0.2530 | |
| GSE53622 | TOE1 | 114034 | 96866 | -0.3335 | 0.0002 | |
| GSE53624 | TOE1 | 114034 | 15576 | 0.0236 | 0.6633 | |
| GSE63941 | TOE1 | 114034 | 204080_at | 0.4309 | 0.1612 | |
| GSE77861 | TOE1 | 114034 | 204080_at | 0.0307 | 0.8565 | |
| GSE97050 | TOE1 | 114034 | A_24_P19828 | 0.2304 | 0.3405 | |
| SRP007169 | TOE1 | 114034 | RNAseq | 0.2219 | 0.6638 | |
| SRP064894 | TOE1 | 114034 | RNAseq | 0.2367 | 0.3031 | |
| SRP133303 | TOE1 | 114034 | RNAseq | -0.1015 | 0.6093 | |
| SRP159526 | TOE1 | 114034 | RNAseq | 1.0278 | 0.0886 | |
| SRP193095 | TOE1 | 114034 | RNAseq | 0.1661 | 0.2299 | |
| SRP219564 | TOE1 | 114034 | RNAseq | 0.1141 | 0.7412 | |
| TCGA | TOE1 | 114034 | RNAseq | -0.0574 | 0.3782 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by TOE1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TOE1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TOE1 | 114034 | 4 | 3 | 23 | |
| GSE20123 | TOE1 | 114034 | 4 | 2 | 24 | |
| GSE43470 | TOE1 | 114034 | 7 | 2 | 34 | |
| GSE46452 | TOE1 | 114034 | 2 | 1 | 56 | |
| GSE47630 | TOE1 | 114034 | 9 | 3 | 28 | |
| GSE54993 | TOE1 | 114034 | 0 | 1 | 69 | |
| GSE54994 | TOE1 | 114034 | 13 | 2 | 38 | |
| GSE60625 | TOE1 | 114034 | 0 | 0 | 11 | |
| GSE74703 | TOE1 | 114034 | 6 | 1 | 29 | |
| GSE74704 | TOE1 | 114034 | 2 | 0 | 18 | |
| TCGA | TOE1 | 114034 | 11 | 16 | 69 |
Total number of gains: 58; Total number of losses: 31; Total Number of normals: 399.
Somatic mutations of TOE1:
Generating mutation plots.
Highly correlated genes for TOE1:
Showing top 20/150 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TOE1 | TPO | 0.756625 | 3 | 0 | 3 |
| TOE1 | UMODL1 | 0.754914 | 3 | 0 | 3 |
| TOE1 | USP27X | 0.734216 | 3 | 0 | 3 |
| TOE1 | NOC4L | 0.70639 | 5 | 0 | 4 |
| TOE1 | SDCCAG8 | 0.702972 | 3 | 0 | 3 |
| TOE1 | GAS6-AS1 | 0.702388 | 3 | 0 | 3 |
| TOE1 | GTF2IRD2 | 0.701649 | 4 | 0 | 4 |
| TOE1 | C7orf26 | 0.700154 | 4 | 0 | 3 |
| TOE1 | ZNF511 | 0.693707 | 4 | 0 | 4 |
| TOE1 | ZNF777 | 0.691725 | 4 | 0 | 3 |
| TOE1 | MIIP | 0.680462 | 7 | 0 | 6 |
| TOE1 | CC2D1B | 0.679976 | 4 | 0 | 3 |
| TOE1 | ZNF48 | 0.678872 | 4 | 0 | 3 |
| TOE1 | ZNF639 | 0.678535 | 4 | 0 | 3 |
| TOE1 | FAM189B | 0.677394 | 5 | 0 | 3 |
| TOE1 | BATF2 | 0.676044 | 3 | 0 | 3 |
| TOE1 | PARS2 | 0.67498 | 5 | 0 | 4 |
| TOE1 | TIMM10 | 0.674027 | 3 | 0 | 3 |
| TOE1 | RTN4RL1 | 0.672762 | 3 | 0 | 3 |
| TOE1 | KAT8 | 0.672187 | 4 | 0 | 3 |
For details and further investigation, click here
