| Full name: thyroid peroxidase | Alias Symbol: TPX | ||
| Type: protein-coding gene | Cytoband: 2p25.3 | ||
| Entrez ID: 7173 | HGNC ID: HGNC:12015 | Ensembl Gene: ENSG00000115705 | OMIM ID: 606765 |
| Drug and gene relationship at DGIdb | |||
Expression of TPO:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TPO | 7173 | 210342_s_at | -0.4393 | 0.2123 | |
| GSE20347 | TPO | 7173 | 210342_s_at | -0.0151 | 0.8838 | |
| GSE23400 | TPO | 7173 | 210342_s_at | -0.0727 | 0.0188 | |
| GSE26886 | TPO | 7173 | 210342_s_at | 0.5668 | 0.0045 | |
| GSE29001 | TPO | 7173 | 210342_s_at | 0.0077 | 0.9691 | |
| GSE38129 | TPO | 7173 | 210342_s_at | -0.2582 | 0.0115 | |
| GSE45670 | TPO | 7173 | 210342_s_at | -0.3765 | 0.0025 | |
| GSE53622 | TPO | 7173 | 69640 | 0.0396 | 0.7395 | |
| GSE53624 | TPO | 7173 | 40301 | 0.0615 | 0.4772 | |
| GSE63941 | TPO | 7173 | 210342_s_at | -0.1173 | 0.6031 | |
| GSE77861 | TPO | 7173 | 210342_s_at | 0.0275 | 0.8393 | |
| GSE97050 | TPO | 7173 | A_33_P3260014 | -0.1498 | 0.4922 | |
| SRP064894 | TPO | 7173 | RNAseq | -0.1426 | 0.7944 | |
| SRP133303 | TPO | 7173 | RNAseq | -1.3746 | 0.0136 | |
| SRP159526 | TPO | 7173 | RNAseq | -1.8346 | 0.0031 | |
| SRP219564 | TPO | 7173 | RNAseq | 0.7681 | 0.4170 | |
| TCGA | TPO | 7173 | RNAseq | -1.7138 | 0.0009 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by TPO expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TPO:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TPO | 7173 | 8 | 2 | 20 | |
| GSE20123 | TPO | 7173 | 8 | 2 | 20 | |
| GSE43470 | TPO | 7173 | 3 | 1 | 39 | |
| GSE46452 | TPO | 7173 | 3 | 4 | 52 | |
| GSE47630 | TPO | 7173 | 7 | 0 | 33 | |
| GSE54993 | TPO | 7173 | 1 | 7 | 62 | |
| GSE54994 | TPO | 7173 | 13 | 0 | 40 | |
| GSE60625 | TPO | 7173 | 0 | 3 | 8 | |
| GSE74703 | TPO | 7173 | 3 | 0 | 33 | |
| GSE74704 | TPO | 7173 | 8 | 1 | 11 | |
| TCGA | TPO | 7173 | 32 | 5 | 59 |
Total number of gains: 86; Total number of losses: 25; Total Number of normals: 377.
Somatic mutations of TPO:
Generating mutation plots.
Highly correlated genes for TPO:
Showing top 20/265 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TPO | DOK7 | 0.839007 | 3 | 0 | 3 |
| TPO | RNF180 | 0.815147 | 3 | 0 | 3 |
| TPO | TTLL9 | 0.808842 | 3 | 0 | 3 |
| TPO | C16orf89 | 0.769846 | 3 | 0 | 3 |
| TPO | RBM43 | 0.763092 | 3 | 0 | 3 |
| TPO | TOE1 | 0.756625 | 3 | 0 | 3 |
| TPO | ZNF527 | 0.752939 | 3 | 0 | 3 |
| TPO | ZNF182 | 0.752526 | 4 | 0 | 3 |
| TPO | ESPNL | 0.751962 | 3 | 0 | 3 |
| TPO | ISLR2 | 0.739796 | 4 | 0 | 4 |
| TPO | ZNF524 | 0.739062 | 4 | 0 | 4 |
| TPO | KRTAP3-1 | 0.731836 | 3 | 0 | 3 |
| TPO | ZBTB47 | 0.731835 | 3 | 0 | 3 |
| TPO | HRCT1 | 0.729188 | 3 | 0 | 3 |
| TPO | DMGDH | 0.728196 | 4 | 0 | 3 |
| TPO | LINC01140 | 0.725858 | 3 | 0 | 3 |
| TPO | PDE6C | 0.721767 | 4 | 0 | 4 |
| TPO | ZNF575 | 0.721223 | 3 | 0 | 3 |
| TPO | C7orf61 | 0.709638 | 3 | 0 | 3 |
| TPO | FFAR1 | 0.703781 | 4 | 0 | 3 |
For details and further investigation, click here
