| Full name: metaxin 2 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 2q31.1 | ||
| Entrez ID: 10651 | HGNC ID: HGNC:7506 | Ensembl Gene: ENSG00000128654 | OMIM ID: 608555 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of MTX2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MTX2 | 10651 | 203517_at | 0.5236 | 0.2643 | |
| GSE20347 | MTX2 | 10651 | 203517_at | 0.3995 | 0.0376 | |
| GSE23400 | MTX2 | 10651 | 203517_at | 0.3013 | 0.0008 | |
| GSE26886 | MTX2 | 10651 | 203517_at | -0.4260 | 0.0925 | |
| GSE29001 | MTX2 | 10651 | 203517_at | 0.1149 | 0.7830 | |
| GSE38129 | MTX2 | 10651 | 203517_at | 0.4848 | 0.0002 | |
| GSE45670 | MTX2 | 10651 | 203517_at | 0.1964 | 0.1858 | |
| GSE53622 | MTX2 | 10651 | 45962 | 0.2220 | 0.0009 | |
| GSE53624 | MTX2 | 10651 | 45962 | 0.2433 | 0.0000 | |
| GSE63941 | MTX2 | 10651 | 203517_at | 0.3261 | 0.4672 | |
| GSE77861 | MTX2 | 10651 | 203517_at | 0.0962 | 0.7424 | |
| GSE97050 | MTX2 | 10651 | A_23_P120335 | 0.0302 | 0.9071 | |
| SRP007169 | MTX2 | 10651 | RNAseq | -0.4070 | 0.2028 | |
| SRP008496 | MTX2 | 10651 | RNAseq | -0.6399 | 0.0010 | |
| SRP064894 | MTX2 | 10651 | RNAseq | -0.0024 | 0.9897 | |
| SRP133303 | MTX2 | 10651 | RNAseq | 0.1689 | 0.1526 | |
| SRP159526 | MTX2 | 10651 | RNAseq | -0.2566 | 0.1869 | |
| SRP193095 | MTX2 | 10651 | RNAseq | -0.3613 | 0.0016 | |
| SRP219564 | MTX2 | 10651 | RNAseq | -0.2588 | 0.2870 | |
| TCGA | MTX2 | 10651 | RNAseq | 0.1271 | 0.0205 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by MTX2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MTX2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MTX2 | 10651 | 9 | 0 | 21 | |
| GSE20123 | MTX2 | 10651 | 9 | 0 | 21 | |
| GSE43470 | MTX2 | 10651 | 5 | 1 | 37 | |
| GSE46452 | MTX2 | 10651 | 1 | 4 | 54 | |
| GSE47630 | MTX2 | 10651 | 4 | 4 | 32 | |
| GSE54993 | MTX2 | 10651 | 0 | 5 | 65 | |
| GSE54994 | MTX2 | 10651 | 12 | 3 | 38 | |
| GSE60625 | MTX2 | 10651 | 0 | 3 | 8 | |
| GSE74703 | MTX2 | 10651 | 4 | 1 | 31 | |
| GSE74704 | MTX2 | 10651 | 5 | 0 | 15 | |
| TCGA | MTX2 | 10651 | 28 | 5 | 63 |
Total number of gains: 77; Total number of losses: 26; Total Number of normals: 385.
Somatic mutations of MTX2:
Generating mutation plots.
Highly correlated genes for MTX2:
Showing top 20/537 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MTX2 | NAA15 | 0.811526 | 3 | 0 | 3 |
| MTX2 | INTS12 | 0.759193 | 3 | 0 | 3 |
| MTX2 | TP53RK | 0.758983 | 3 | 0 | 3 |
| MTX2 | CHD1 | 0.754498 | 3 | 0 | 3 |
| MTX2 | PPP2CA | 0.751766 | 3 | 0 | 3 |
| MTX2 | TYW5 | 0.749848 | 4 | 0 | 4 |
| MTX2 | NTPCR | 0.742636 | 3 | 0 | 3 |
| MTX2 | CREG1 | 0.739812 | 3 | 0 | 3 |
| MTX2 | NUS1 | 0.736265 | 3 | 0 | 3 |
| MTX2 | CETN3 | 0.726631 | 3 | 0 | 3 |
| MTX2 | SRC | 0.72658 | 3 | 0 | 3 |
| MTX2 | NBEAL1 | 0.725034 | 3 | 0 | 3 |
| MTX2 | TOPORS | 0.72322 | 3 | 0 | 3 |
| MTX2 | RBM15B | 0.719856 | 3 | 0 | 3 |
| MTX2 | PPP1CC | 0.719527 | 4 | 0 | 4 |
| MTX2 | ARL5B | 0.718362 | 3 | 0 | 3 |
| MTX2 | MTFMT | 0.718017 | 3 | 0 | 3 |
| MTX2 | BAZ2B | 0.717239 | 4 | 0 | 4 |
| MTX2 | CRNKL1 | 0.710147 | 4 | 0 | 4 |
| MTX2 | TFDP2 | 0.706755 | 3 | 0 | 3 |
For details and further investigation, click here
