PRKAG1

 

Full name: protein kinase AMP-activated non-catalytic subunit gamma 1 Alias Symbol: 
Type: protein-coding gene Cytoband: 12q13.12
Entrez ID: 5571 HGNC ID: HGNC:9385 Ensembl Gene: ENSG00000181929 OMIM ID: 602742
Drug and gene relationship at DGIdb
Screen Evidence:

 

PRKAG1 involved pathways:

KEGG pathway Description View
hsa04068FoxO signaling pathway
hsa04152AMPK signaling pathway
hsa04211Longevity regulating pathway - mammal
hsa04213Longevity regulating pathway - multiple species
hsa04710Circadian rhythm
hsa04910Insulin signaling pathway
hsa04920Adipocytokine signaling pathway
hsa04921Oxytocin signaling pathway
hsa04922Glucagon signaling pathway
hsa04931Insulin resistance
hsa04932Non-alcoholic fatty liver disease (NAFLD)

 

Expression of PRKAG1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 PRKAG1 5571 201805_at -0.4129 0.2863
GSE20347 PRKAG1 5571 201805_at -0.2353 0.0410
GSE23400 PRKAG1 5571 201805_at -0.1130 0.0322
GSE26886 PRKAG1 5571 201805_at -0.9610 0.0000
GSE29001 PRKAG1 5571 201805_at -0.2573 0.2219
GSE38129 PRKAG1 5571 201805_at -0.1650 0.1627
GSE45670 PRKAG1 5571 201805_at -0.0476 0.7168
GSE53622 PRKAG1 5571 28628 -0.1377 0.0195
GSE53624 PRKAG1 5571 28628 -0.2883 0.0000
GSE63941 PRKAG1 5571 201805_at 1.1119 0.0042
GSE77861 PRKAG1 5571 201805_at -0.1119 0.4766
GSE97050 PRKAG1 5571 A_23_P36513 -0.4532 0.1324
SRP007169 PRKAG1 5571 RNAseq -0.1084 0.7493
SRP008496 PRKAG1 5571 RNAseq -0.1981 0.4030
SRP064894 PRKAG1 5571 RNAseq -0.3355 0.0013
SRP133303 PRKAG1 5571 RNAseq -0.0350 0.7530
SRP159526 PRKAG1 5571 RNAseq -0.4111 0.0537
SRP193095 PRKAG1 5571 RNAseq -0.4186 0.0002
SRP219564 PRKAG1 5571 RNAseq -0.4287 0.0637
TCGA PRKAG1 5571 RNAseq -0.0036 0.9436

Upregulated datasets: 1; Downregulated datasets: 0.  

 

Survival by PRKAG1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of PRKAG1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PRKAG1 5571 6 1 23
GSE20123 PRKAG1 5571 6 1 23
GSE43470 PRKAG1 5571 4 1 38
GSE46452 PRKAG1 5571 8 1 50
GSE47630 PRKAG1 5571 11 2 27
GSE54993 PRKAG1 5571 0 5 65
GSE54994 PRKAG1 5571 4 1 48
GSE60625 PRKAG1 5571 0 0 11
GSE74703 PRKAG1 5571 4 1 31
GSE74704 PRKAG1 5571 4 1 15
TCGA PRKAG1 5571 16 15 65

Total number of gains: 63; Total number of losses: 29; Total Number of normals: 396.  

 

Somatic mutations of PRKAG1:

 

Generating mutation plots.

 

Highly correlated genes for PRKAG1:

 

Showing top 20/653 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PRKAG1DLG30.797082303
PRKAG1SLTM0.783474303
PRKAG1DHX350.778084303
PRKAG1TOPORS0.776191303
PRKAG1KIAA05560.764923404
PRKAG1NIPSNAP3A0.761864404
PRKAG1TMEM2180.761351404
PRKAG1CGNL10.75799303
PRKAG1ESYT20.753789303
PRKAG1INPP10.753572303
PRKAG1TMEM800.750732303
PRKAG1NUB10.748499303
PRKAG1THAP20.735254303
PRKAG1SLC35C20.733221303
PRKAG1TMEM2050.731935303
PRKAG1FEM1A0.730948303
PRKAG1PRPF38A0.72788505
PRKAG1TMEM50B0.724468505
PRKAG1ALKBH80.724113303
PRKAG1FGFR20.721962303

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