TP53

 

Full name: tumor protein p53 Alias Symbol: p53|LFS1
Type: protein-coding gene Cytoband: 17p13.1
Entrez ID: 7157 HGNC ID: HGNC:11998 Ensembl Gene: ENSG00000141510 OMIM ID: 191170
Drug and gene relationship at DGIdb
Screen Evidence:
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

TP53 involved pathways:

KEGG pathway Description View
hsa04010MAPK signaling pathway
hsa04071Sphingolipid signaling pathway
hsa04110Cell cycle
hsa04115p53 signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04210Apoptosis
hsa04211Longevity regulating pathway - mammal
hsa04310Wnt signaling pathway
hsa04722Neurotrophin signaling pathway
hsa04919Thyroid hormone signaling pathway
hsa05160Hepatitis C
hsa05161Hepatitis B
hsa05162Measles
hsa05166HTLV-I infection
hsa05169Epstein-Barr virus infection
hsa05200Pathways in cancer
hsa05205Proteoglycans in cancer
hsa05214Glioma
hsa05215Prostate cancer
hsa05218Melanoma
hsa05219Bladder cancer
hsa05220Chronic myeloid leukemia

 

Expression of TP53:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 TP53 7157 201746_at 0.6971 0.3529
GSE20347 TP53 7157 201746_at -0.5027 0.1934
GSE23400 TP53 7157 201746_at 0.3392 0.0493
GSE26886 TP53 7157 201746_at -0.0009 0.9985
GSE29001 TP53 7157 201746_at -0.2460 0.6931
GSE38129 TP53 7157 201746_at -0.2288 0.5080
GSE45670 TP53 7157 201746_at 0.1156 0.7433
GSE53622 TP53 7157 53730 0.1743 0.2417
GSE53624 TP53 7157 113446 -0.2607 0.0120
GSE63941 TP53 7157 201746_at 0.7975 0.5933
GSE77861 TP53 7157 201746_at -0.9009 0.1143
GSE97050 TP53 7157 A_23_P26810 0.1066 0.8983
SRP007169 TP53 7157 RNAseq 0.3504 0.6696
SRP008496 TP53 7157 RNAseq 0.5901 0.4346
SRP064894 TP53 7157 RNAseq 0.5442 0.0200
SRP133303 TP53 7157 RNAseq -0.2984 0.3041
SRP159526 TP53 7157 RNAseq -0.1860 0.6919
SRP193095 TP53 7157 RNAseq -0.2809 0.1150
SRP219564 TP53 7157 RNAseq 0.3477 0.3721
TCGA TP53 7157 RNAseq 0.1978 0.0886

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by TP53 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of TP53:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 TP53 7157 4 2 24
GSE20123 TP53 7157 4 3 23
GSE43470 TP53 7157 1 6 36
GSE46452 TP53 7157 34 1 24
GSE47630 TP53 7157 7 1 32
GSE54993 TP53 7157 4 3 63
GSE54994 TP53 7157 5 8 40
GSE60625 TP53 7157 4 0 7
GSE74703 TP53 7157 1 3 32
GSE74704 TP53 7157 2 1 17
TCGA TP53 7157 17 21 58

Total number of gains: 83; Total number of losses: 49; Total Number of normals: 356.  

 

Somatic mutations of TP53:

 

Generating mutation plots.

 

Highly correlated genes for TP53:

 

Showing all 15 correlated genes with mean PCC>0.5.

Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
TP53PADI30.655282303
TP53ACAD90.650426303
TP53STK110.645304303
TP53TRAPPC50.613215303
TP53HS3ST3B10.600137403
TP53ARRDC10.575472303
TP53TSTA30.569214403
TP53C6orf470.567739403
TP53DCAF50.563893303
TP53IGH0.562476303
TP53APH1A0.559142503
TP53PRKCD0.54193403
TP53ZBTB220.541182403
TP53ERCC10.540906503
TP53TBC1D22A0.527518403

For details and further investigation, click here