| Full name: aph-1 homolog A, gamma-secretase subunit | Alias Symbol: APH-1A|CGI-78 | ||
| Type: protein-coding gene | Cytoband: 1q21.2 | ||
| Entrez ID: 51107 | HGNC ID: HGNC:29509 | Ensembl Gene: ENSG00000117362 | OMIM ID: 607629 |
| Drug and gene relationship at DGIdb | |||
APH1A involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04330 | Notch signaling pathway |
Expression of APH1A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | APH1A | 51107 | 218389_s_at | 0.3385 | 0.4497 | |
| GSE20347 | APH1A | 51107 | 218389_s_at | -0.5343 | 0.0000 | |
| GSE23400 | APH1A | 51107 | 218389_s_at | 0.0107 | 0.9063 | |
| GSE26886 | APH1A | 51107 | 218389_s_at | -1.1908 | 0.0000 | |
| GSE29001 | APH1A | 51107 | 218389_s_at | -0.3617 | 0.1702 | |
| GSE38129 | APH1A | 51107 | 218389_s_at | -0.0074 | 0.9683 | |
| GSE45670 | APH1A | 51107 | 218389_s_at | -0.1109 | 0.4051 | |
| GSE53622 | APH1A | 51107 | 77405 | -0.0040 | 0.9660 | |
| GSE53624 | APH1A | 51107 | 59678 | -0.3479 | 0.0000 | |
| GSE63941 | APH1A | 51107 | 218389_s_at | -0.3910 | 0.2486 | |
| GSE77861 | APH1A | 51107 | 218389_s_at | -0.1730 | 0.4736 | |
| GSE97050 | APH1A | 51107 | A_23_P930 | 0.2841 | 0.4043 | |
| SRP007169 | APH1A | 51107 | RNAseq | -1.3195 | 0.0001 | |
| SRP008496 | APH1A | 51107 | RNAseq | -0.9601 | 0.0000 | |
| SRP064894 | APH1A | 51107 | RNAseq | 0.1465 | 0.5069 | |
| SRP133303 | APH1A | 51107 | RNAseq | -0.1658 | 0.1734 | |
| SRP159526 | APH1A | 51107 | RNAseq | 0.3049 | 0.0560 | |
| SRP193095 | APH1A | 51107 | RNAseq | -0.3256 | 0.0076 | |
| SRP219564 | APH1A | 51107 | RNAseq | 0.1360 | 0.7324 | |
| TCGA | APH1A | 51107 | RNAseq | 0.0840 | 0.0595 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by APH1A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of APH1A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | APH1A | 51107 | 15 | 0 | 15 | |
| GSE20123 | APH1A | 51107 | 15 | 0 | 15 | |
| GSE43470 | APH1A | 51107 | 6 | 1 | 36 | |
| GSE46452 | APH1A | 51107 | 2 | 1 | 56 | |
| GSE47630 | APH1A | 51107 | 14 | 0 | 26 | |
| GSE54993 | APH1A | 51107 | 0 | 3 | 67 | |
| GSE54994 | APH1A | 51107 | 15 | 0 | 38 | |
| GSE60625 | APH1A | 51107 | 0 | 0 | 11 | |
| GSE74703 | APH1A | 51107 | 6 | 1 | 29 | |
| GSE74704 | APH1A | 51107 | 7 | 0 | 13 | |
| TCGA | APH1A | 51107 | 38 | 2 | 56 |
Total number of gains: 118; Total number of losses: 8; Total Number of normals: 362.
Somatic mutations of APH1A:
Generating mutation plots.
Highly correlated genes for APH1A:
Showing top 20/711 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| APH1A | GTF2A1 | 0.836555 | 3 | 0 | 3 |
| APH1A | RASA2 | 0.836546 | 3 | 0 | 3 |
| APH1A | ZNF92 | 0.814355 | 3 | 0 | 3 |
| APH1A | PDLIM5 | 0.750639 | 3 | 0 | 3 |
| APH1A | RNF149 | 0.74545 | 4 | 0 | 4 |
| APH1A | C3orf38 | 0.741555 | 3 | 0 | 3 |
| APH1A | PROM2 | 0.736884 | 3 | 0 | 3 |
| APH1A | PDXDC1 | 0.732591 | 3 | 0 | 3 |
| APH1A | STK11IP | 0.723701 | 3 | 0 | 3 |
| APH1A | NAAA | 0.720127 | 4 | 0 | 3 |
| APH1A | GTF3A | 0.718758 | 3 | 0 | 3 |
| APH1A | RBM5 | 0.717461 | 3 | 0 | 3 |
| APH1A | MAP4K5 | 0.715848 | 3 | 0 | 3 |
| APH1A | BLOC1S2 | 0.709953 | 3 | 0 | 3 |
| APH1A | PKN2 | 0.704043 | 3 | 0 | 3 |
| APH1A | SLC35B3 | 0.701276 | 4 | 0 | 4 |
| APH1A | RBM45 | 0.699484 | 3 | 0 | 3 |
| APH1A | GLUD2 | 0.699313 | 4 | 0 | 4 |
| APH1A | SEC24B | 0.693168 | 3 | 0 | 3 |
| APH1A | TRPC4AP | 0.690348 | 3 | 0 | 3 |
For details and further investigation, click here
