| Full name: ERCC excision repair 1, endonuclease non-catalytic subunit | Alias Symbol: RAD10 | ||
| Type: protein-coding gene | Cytoband: 19q13.32 | ||
| Entrez ID: 2067 | HGNC ID: HGNC:3433 | Ensembl Gene: ENSG00000012061 | OMIM ID: 126380 |
| Related drugs: CYCLOSPORINE, FLUOROURACIL, HERBIMYCIN... [more] | |||
Screen Evidence:
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Expression of ERCC1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ERCC1 | 2067 | 203720_s_at | -0.0081 | 0.9813 | |
| GSE20347 | ERCC1 | 2067 | 203720_s_at | -0.0467 | 0.8006 | |
| GSE23400 | ERCC1 | 2067 | 203720_s_at | 0.1512 | 0.0138 | |
| GSE26886 | ERCC1 | 2067 | 203720_s_at | 0.5864 | 0.0132 | |
| GSE29001 | ERCC1 | 2067 | 203719_at | 0.0957 | 0.8119 | |
| GSE38129 | ERCC1 | 2067 | 203720_s_at | 0.0777 | 0.5295 | |
| GSE45670 | ERCC1 | 2067 | 203720_s_at | 0.2405 | 0.1262 | |
| GSE53622 | ERCC1 | 2067 | 12053 | 0.1926 | 0.0002 | |
| GSE53624 | ERCC1 | 2067 | 12053 | 0.2732 | 0.0001 | |
| GSE63941 | ERCC1 | 2067 | 203720_s_at | 0.1906 | 0.6864 | |
| GSE77861 | ERCC1 | 2067 | 203720_s_at | 0.1398 | 0.7369 | |
| GSE97050 | ERCC1 | 2067 | A_33_P3228128 | 0.1253 | 0.6426 | |
| SRP007169 | ERCC1 | 2067 | RNAseq | -0.4671 | 0.1887 | |
| SRP008496 | ERCC1 | 2067 | RNAseq | -0.6650 | 0.0022 | |
| SRP064894 | ERCC1 | 2067 | RNAseq | 0.2971 | 0.2075 | |
| SRP133303 | ERCC1 | 2067 | RNAseq | -0.1104 | 0.4718 | |
| SRP159526 | ERCC1 | 2067 | RNAseq | 0.5381 | 0.0432 | |
| SRP193095 | ERCC1 | 2067 | RNAseq | 0.0104 | 0.9075 | |
| SRP219564 | ERCC1 | 2067 | RNAseq | 0.1104 | 0.6341 | |
| TCGA | ERCC1 | 2067 | RNAseq | 0.0478 | 0.4605 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by ERCC1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ERCC1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ERCC1 | 2067 | 4 | 5 | 21 | |
| GSE20123 | ERCC1 | 2067 | 4 | 4 | 22 | |
| GSE43470 | ERCC1 | 2067 | 3 | 11 | 29 | |
| GSE46452 | ERCC1 | 2067 | 45 | 1 | 13 | |
| GSE47630 | ERCC1 | 2067 | 8 | 6 | 26 | |
| GSE54993 | ERCC1 | 2067 | 17 | 4 | 49 | |
| GSE54994 | ERCC1 | 2067 | 6 | 12 | 35 | |
| GSE60625 | ERCC1 | 2067 | 9 | 0 | 2 | |
| GSE74703 | ERCC1 | 2067 | 3 | 7 | 26 | |
| GSE74704 | ERCC1 | 2067 | 4 | 2 | 14 | |
| TCGA | ERCC1 | 2067 | 15 | 16 | 65 |
Total number of gains: 118; Total number of losses: 68; Total Number of normals: 302.
Somatic mutations of ERCC1:
Generating mutation plots.
Highly correlated genes for ERCC1:
Showing top 20/104 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ERCC1 | FOXJ2 | 0.693375 | 3 | 0 | 3 |
| ERCC1 | CPNE5 | 0.682205 | 3 | 0 | 3 |
| ERCC1 | SPIB | 0.636858 | 3 | 0 | 3 |
| ERCC1 | ZNF446 | 0.635679 | 3 | 0 | 3 |
| ERCC1 | BIK | 0.630183 | 4 | 0 | 4 |
| ERCC1 | GPAA1 | 0.627685 | 3 | 0 | 3 |
| ERCC1 | CUEDC2 | 0.619731 | 4 | 0 | 4 |
| ERCC1 | LMO1 | 0.614401 | 3 | 0 | 3 |
| ERCC1 | CENPV | 0.602808 | 3 | 0 | 3 |
| ERCC1 | THBS4 | 0.598394 | 4 | 0 | 4 |
| ERCC1 | TCTN1 | 0.595326 | 4 | 0 | 3 |
| ERCC1 | NRCAM | 0.588932 | 5 | 0 | 3 |
| ERCC1 | SPHK2 | 0.587679 | 4 | 0 | 3 |
| ERCC1 | P2RX5 | 0.583116 | 3 | 0 | 3 |
| ERCC1 | CCDC124 | 0.579778 | 3 | 0 | 3 |
| ERCC1 | MYH9 | 0.578892 | 3 | 0 | 3 |
| ERCC1 | CHST14 | 0.575565 | 3 | 0 | 3 |
| ERCC1 | LRRC23 | 0.575435 | 3 | 0 | 3 |
| ERCC1 | ENO1 | 0.57442 | 4 | 0 | 3 |
| ERCC1 | NLRP7 | 0.563754 | 5 | 0 | 3 |
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