PRKCD

 

Full name: protein kinase C delta Alias Symbol: 
Type: protein-coding gene Cytoband: 3p21.1
Entrez ID: 5580 HGNC ID: HGNC:9399 Ensembl Gene: ENSG00000163932 OMIM ID: 176977
Drug and gene relationship at DGIdb

 

PRKCD involved pathways:

KEGG pathway Description View
hsa04062Chemokine signaling pathway
hsa04270Vascular smooth muscle contraction
hsa04530Tight junction
hsa04666Fc gamma R-mediated phagocytosis
hsa04722Neurotrophin signaling pathway
hsa04750Inflammatory mediator regulation of TRP channels
hsa04912GnRH signaling pathway
hsa04915Estrogen signaling pathway
hsa04930Type II diabetes mellitus
hsa04931Insulin resistance
hsa04933AGE-RAGE signaling pathway in diabetic complications

 

Expression of PRKCD:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 PRKCD 5580 202545_at 0.4477 0.3399
GSE20347 PRKCD 5580 202545_at -0.7659 0.0000
GSE23400 PRKCD 5580 202545_at -0.4322 0.0000
GSE26886 PRKCD 5580 202545_at -1.1847 0.0003
GSE29001 PRKCD 5580 202545_at -0.4983 0.0661
GSE38129 PRKCD 5580 202545_at -0.4974 0.0025
GSE45670 PRKCD 5580 202545_at -0.2658 0.0613
GSE53622 PRKCD 5580 56937 -0.5532 0.0000
GSE53624 PRKCD 5580 56937 -0.7666 0.0000
GSE63941 PRKCD 5580 202545_at 1.4398 0.0257
GSE77861 PRKCD 5580 202545_at -0.3882 0.0533
GSE97050 PRKCD 5580 A_23_P144054 0.3609 0.3417
SRP007169 PRKCD 5580 RNAseq -1.2246 0.0121
SRP008496 PRKCD 5580 RNAseq -1.2091 0.0000
SRP064894 PRKCD 5580 RNAseq -0.8269 0.0000
SRP133303 PRKCD 5580 RNAseq -0.6719 0.0000
SRP159526 PRKCD 5580 RNAseq -0.8792 0.0086
SRP193095 PRKCD 5580 RNAseq -0.8080 0.0007
SRP219564 PRKCD 5580 RNAseq -0.8348 0.0612
TCGA PRKCD 5580 RNAseq -0.2529 0.0000

Upregulated datasets: 1; Downregulated datasets: 3.  

 

Survival by PRKCD expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of PRKCD:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PRKCD 5580 0 19 11
GSE20123 PRKCD 5580 0 20 10
GSE43470 PRKCD 5580 0 18 25
GSE46452 PRKCD 5580 2 17 40
GSE47630 PRKCD 5580 1 24 15
GSE54993 PRKCD 5580 6 2 62
GSE54994 PRKCD 5580 0 32 21
GSE60625 PRKCD 5580 5 0 6
GSE74703 PRKCD 5580 0 14 22
GSE74704 PRKCD 5580 0 13 7
TCGA PRKCD 5580 0 78 18

Total number of gains: 14; Total number of losses: 237; Total Number of normals: 237.  

 

Somatic mutations of PRKCD:

 

Generating mutation plots.

 

Highly correlated genes for PRKCD:

 

Showing top 20/924 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PRKCDCXCL160.759328303
PRKCDDUSP230.725368404
PRKCDTMCO60.717227303
PRKCDLTA4H0.704686303
PRKCDKDM1B0.700903303
PRKCDSTARD100.696405403
PRKCDCARD160.690119303
PRKCDEMC30.68654909
PRKCDBNIPL0.68372505
PRKCDPRELID10.681075303
PRKCDSIAE0.679028505
PRKCDMYD880.6789031109
PRKCDCOMMD90.676651403
PRKCDWDFY10.675658303
PRKCDVSIG10L0.675301505
PRKCDEXOC80.673322303
PRKCDCCDC120.67075605
PRKCDTP53I30.66836310010
PRKCDPHF230.667287403
PRKCDSLC25A390.665837606

For details and further investigation, click here