| Full name: peptidyl arginine deiminase 3 | Alias Symbol: PDI3 | ||
| Type: protein-coding gene | Cytoband: 1p36.13 | ||
| Entrez ID: 51702 | HGNC ID: HGNC:18337 | Ensembl Gene: ENSG00000142619 | OMIM ID: 606755 |
| Drug and gene relationship at DGIdb | |||
Expression of PADI3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PADI3 | 51702 | 220779_at | 0.7537 | 0.7321 | |
| GSE20347 | PADI3 | 51702 | 220779_at | -0.0077 | 0.9858 | |
| GSE23400 | PADI3 | 51702 | 220779_at | -0.7688 | 0.0000 | |
| GSE26886 | PADI3 | 51702 | 220779_at | 0.0991 | 0.7646 | |
| GSE29001 | PADI3 | 51702 | 220779_at | -0.6033 | 0.0715 | |
| GSE38129 | PADI3 | 51702 | 220779_at | 0.0275 | 0.9448 | |
| GSE45670 | PADI3 | 51702 | 220779_at | -0.1711 | 0.8384 | |
| GSE53622 | PADI3 | 51702 | 11918 | -0.3738 | 0.3065 | |
| GSE53624 | PADI3 | 51702 | 11918 | -1.1779 | 0.0000 | |
| GSE63941 | PADI3 | 51702 | 220779_at | 2.5712 | 0.1055 | |
| GSE77861 | PADI3 | 51702 | 220779_at | -0.3388 | 0.3646 | |
| GSE97050 | PADI3 | 51702 | A_23_P126869 | 0.1122 | 0.9107 | |
| SRP007169 | PADI3 | 51702 | RNAseq | -0.4973 | 0.5755 | |
| SRP008496 | PADI3 | 51702 | RNAseq | -1.1862 | 0.1953 | |
| SRP064894 | PADI3 | 51702 | RNAseq | -2.1148 | 0.0003 | |
| SRP133303 | PADI3 | 51702 | RNAseq | -0.3407 | 0.5284 | |
| SRP219564 | PADI3 | 51702 | RNAseq | -1.7762 | 0.2151 | |
| TCGA | PADI3 | 51702 | RNAseq | 2.1228 | 0.0000 |
Upregulated datasets: 1; Downregulated datasets: 2.
Survival by PADI3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PADI3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PADI3 | 51702 | 0 | 5 | 25 | |
| GSE20123 | PADI3 | 51702 | 0 | 4 | 26 | |
| GSE43470 | PADI3 | 51702 | 0 | 8 | 35 | |
| GSE46452 | PADI3 | 51702 | 5 | 1 | 53 | |
| GSE47630 | PADI3 | 51702 | 8 | 3 | 29 | |
| GSE54993 | PADI3 | 51702 | 3 | 1 | 66 | |
| GSE54994 | PADI3 | 51702 | 10 | 4 | 39 | |
| GSE60625 | PADI3 | 51702 | 0 | 0 | 11 | |
| GSE74703 | PADI3 | 51702 | 0 | 5 | 31 | |
| GSE74704 | PADI3 | 51702 | 0 | 0 | 20 | |
| TCGA | PADI3 | 51702 | 9 | 22 | 65 |
Total number of gains: 35; Total number of losses: 53; Total Number of normals: 400.
Somatic mutations of PADI3:
Generating mutation plots.
Highly correlated genes for PADI3:
Showing top 20/119 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PADI3 | ZNF879 | 0.697852 | 3 | 0 | 3 |
| PADI3 | TP53 | 0.655282 | 3 | 0 | 3 |
| PADI3 | MMS19 | 0.652047 | 3 | 0 | 3 |
| PADI3 | ACOT4 | 0.64681 | 3 | 0 | 3 |
| PADI3 | GPR87 | 0.629242 | 4 | 0 | 4 |
| PADI3 | TSPAN1 | 0.61506 | 4 | 0 | 4 |
| PADI3 | UBE2D1 | 0.606412 | 3 | 0 | 3 |
| PADI3 | UBAP1 | 0.597546 | 4 | 0 | 3 |
| PADI3 | TNNI2 | 0.591449 | 3 | 0 | 3 |
| PADI3 | SH3TC2 | 0.587249 | 4 | 0 | 3 |
| PADI3 | CPTP | 0.586583 | 5 | 0 | 3 |
| PADI3 | MOS | 0.584504 | 3 | 0 | 3 |
| PADI3 | RASSF7 | 0.581359 | 4 | 0 | 4 |
| PADI3 | PRSS2 | 0.579481 | 4 | 0 | 3 |
| PADI3 | FAM83F | 0.564423 | 5 | 0 | 3 |
| PADI3 | PLEKHG6 | 0.563123 | 5 | 0 | 3 |
| PADI3 | MTERF4 | 0.56086 | 4 | 0 | 3 |
| PADI3 | PPP1R13L | 0.558691 | 8 | 0 | 4 |
| PADI3 | FAT2 | 0.557101 | 5 | 0 | 3 |
| PADI3 | GPX3 | 0.555381 | 4 | 0 | 3 |
For details and further investigation, click here
