| Full name: thyrotropin releasing hormone | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 3q22.1 | ||
| Entrez ID: 7200 | HGNC ID: HGNC:12298 | Ensembl Gene: ENSG00000170893 | OMIM ID: 613879 |
| Drug and gene relationship at DGIdb | |||
Expression of TRH:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TRH | 7200 | 206622_at | -0.0470 | 0.8948 | |
| GSE20347 | TRH | 7200 | 206622_at | 0.0203 | 0.8231 | |
| GSE23400 | TRH | 7200 | 206622_at | -0.0987 | 0.0110 | |
| GSE26886 | TRH | 7200 | 206622_at | 0.0186 | 0.8816 | |
| GSE29001 | TRH | 7200 | 206622_at | -0.0238 | 0.9097 | |
| GSE38129 | TRH | 7200 | 206622_at | -0.0455 | 0.6350 | |
| GSE45670 | TRH | 7200 | 206622_at | 0.0149 | 0.8789 | |
| GSE53622 | TRH | 7200 | 122791 | -0.2335 | 0.0072 | |
| GSE53624 | TRH | 7200 | 122791 | -0.1562 | 0.1647 | |
| GSE63941 | TRH | 7200 | 206622_at | -0.0460 | 0.7411 | |
| GSE77861 | TRH | 7200 | 206622_at | -0.0950 | 0.3679 | |
| GSE97050 | TRH | 7200 | A_23_P132760 | 0.0793 | 0.7040 | |
| TCGA | TRH | 7200 | RNAseq | 0.9593 | 0.4421 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by TRH expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TRH:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TRH | 7200 | 17 | 0 | 13 | |
| GSE20123 | TRH | 7200 | 17 | 0 | 13 | |
| GSE43470 | TRH | 7200 | 19 | 0 | 24 | |
| GSE46452 | TRH | 7200 | 15 | 4 | 40 | |
| GSE47630 | TRH | 7200 | 18 | 3 | 19 | |
| GSE54993 | TRH | 7200 | 2 | 8 | 60 | |
| GSE54994 | TRH | 7200 | 32 | 3 | 18 | |
| GSE60625 | TRH | 7200 | 0 | 6 | 5 | |
| GSE74703 | TRH | 7200 | 17 | 0 | 19 | |
| GSE74704 | TRH | 7200 | 13 | 0 | 7 | |
| TCGA | TRH | 7200 | 59 | 5 | 32 |
Total number of gains: 209; Total number of losses: 29; Total Number of normals: 250.
Somatic mutations of TRH:
Generating mutation plots.
Highly correlated genes for TRH:
Showing top 20/1087 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TRH | DCD | 0.832328 | 3 | 0 | 3 |
| TRH | ZNF81 | 0.763238 | 3 | 0 | 3 |
| TRH | NUDT16L1 | 0.759454 | 3 | 0 | 3 |
| TRH | SLC25A48 | 0.729871 | 3 | 0 | 3 |
| TRH | MAGEA8 | 0.726399 | 3 | 0 | 3 |
| TRH | ABCB9 | 0.726216 | 3 | 0 | 3 |
| TRH | BSX | 0.716579 | 3 | 0 | 3 |
| TRH | CCL13 | 0.716387 | 3 | 0 | 3 |
| TRH | ESPNL | 0.714196 | 4 | 0 | 4 |
| TRH | SCGN | 0.71161 | 6 | 0 | 5 |
| TRH | KIR3DL3 | 0.70978 | 6 | 0 | 5 |
| TRH | SCGB1D1 | 0.705789 | 3 | 0 | 3 |
| TRH | GABRD | 0.70464 | 4 | 0 | 4 |
| TRH | ADAM21 | 0.704496 | 5 | 0 | 3 |
| TRH | LACRT | 0.700717 | 3 | 0 | 3 |
| TRH | MS4A12 | 0.698475 | 5 | 0 | 5 |
| TRH | OR4D1 | 0.69481 | 4 | 0 | 3 |
| TRH | SBNO2 | 0.693179 | 4 | 0 | 3 |
| TRH | TAS2R1 | 0.691935 | 4 | 0 | 3 |
| TRH | CER1 | 0.689184 | 5 | 0 | 5 |
For details and further investigation, click here
