| Full name: killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 3 | Alias Symbol: KIRC1|KIR3DL7|KIR44|CD158Z | ||
| Type: protein-coding gene | Cytoband: 19q13.42 | ||
| Entrez ID: 115653 | HGNC ID: HGNC:16312 | Ensembl Gene: ENSG00000242019 | OMIM ID: 610095 |
| Drug and gene relationship at DGIdb | |||
KIR3DL3 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04612 | Antigen processing and presentation |
Expression of KIR3DL3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KIR3DL3 | 115653 | 216676_x_at | 0.2892 | 0.2749 | |
| GSE20347 | KIR3DL3 | 115653 | 216676_x_at | 0.1368 | 0.2798 | |
| GSE23400 | KIR3DL3 | 115653 | 216676_x_at | -0.0460 | 0.2756 | |
| GSE26886 | KIR3DL3 | 115653 | 216676_x_at | 0.0152 | 0.8894 | |
| GSE29001 | KIR3DL3 | 115653 | 216676_x_at | -0.0979 | 0.5511 | |
| GSE38129 | KIR3DL3 | 115653 | 216676_x_at | -0.0222 | 0.8568 | |
| GSE45670 | KIR3DL3 | 115653 | 216676_x_at | 0.1064 | 0.3278 | |
| GSE63941 | KIR3DL3 | 115653 | 216676_x_at | 0.3164 | 0.0429 | |
| GSE77861 | KIR3DL3 | 115653 | 216676_x_at | -0.0883 | 0.4970 | |
| GSE97050 | KIR3DL3 | 115653 | A_23_P370574 | 0.2105 | 0.3512 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by KIR3DL3 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of KIR3DL3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KIR3DL3 | 115653 | 3 | 4 | 23 | |
| GSE20123 | KIR3DL3 | 115653 | 3 | 3 | 24 | |
| GSE43470 | KIR3DL3 | 115653 | 3 | 11 | 29 | |
| GSE46452 | KIR3DL3 | 115653 | 45 | 1 | 13 | |
| GSE47630 | KIR3DL3 | 115653 | 8 | 6 | 26 | |
| GSE54993 | KIR3DL3 | 115653 | 17 | 4 | 49 | |
| GSE54994 | KIR3DL3 | 115653 | 4 | 13 | 36 | |
| GSE60625 | KIR3DL3 | 115653 | 9 | 0 | 2 | |
| GSE74703 | KIR3DL3 | 115653 | 3 | 7 | 26 | |
| GSE74704 | KIR3DL3 | 115653 | 3 | 1 | 16 | |
| TCGA | KIR3DL3 | 115653 | 19 | 14 | 63 |
Total number of gains: 117; Total number of losses: 64; Total Number of normals: 307.
Somatic mutations of KIR3DL3:
Generating mutation plots.
Highly correlated genes for KIR3DL3:
Showing top 20/897 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KIR3DL3 | ERN1 | 0.79507 | 4 | 0 | 4 |
| KIR3DL3 | KHDRBS2 | 0.793502 | 4 | 0 | 4 |
| KIR3DL3 | IFNA4 | 0.786583 | 5 | 0 | 5 |
| KIR3DL3 | NXPE4 | 0.786288 | 5 | 0 | 5 |
| KIR3DL3 | LIMD1 | 0.785156 | 3 | 0 | 3 |
| KIR3DL3 | ENGASE | 0.775788 | 3 | 0 | 3 |
| KIR3DL3 | HECW1 | 0.76325 | 6 | 0 | 6 |
| KIR3DL3 | FAM124B | 0.756799 | 4 | 0 | 4 |
| KIR3DL3 | ADAMTS12 | 0.756201 | 5 | 0 | 5 |
| KIR3DL3 | RNF17 | 0.755305 | 5 | 0 | 5 |
| KIR3DL3 | TRPM3 | 0.754665 | 6 | 0 | 5 |
| KIR3DL3 | CALCR | 0.754366 | 5 | 0 | 5 |
| KIR3DL3 | REG3A | 0.753117 | 4 | 0 | 3 |
| KIR3DL3 | PHF7 | 0.751988 | 5 | 0 | 5 |
| KIR3DL3 | OR1F1 | 0.745971 | 6 | 0 | 5 |
| KIR3DL3 | MCF2L | 0.745709 | 3 | 0 | 3 |
| KIR3DL3 | PGC | 0.742875 | 4 | 0 | 4 |
| KIR3DL3 | SCGN | 0.742026 | 4 | 0 | 4 |
| KIR3DL3 | SHISA8 | 0.741203 | 3 | 0 | 3 |
| KIR3DL3 | FSCN3 | 0.740719 | 6 | 0 | 6 |
For details and further investigation, click here
